2.5.1.74: 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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For detailed information about 1,4-dihydroxy-2-naphthoate polyprenyltransferase, go to the full flat file.

Reaction

Synonyms

1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenA

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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Results	in table
1	Activating Compound
14318	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	General Information
5	IC50 Value
7	Inhibitors
3	Localization
4	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
14	Pathway
1	pH Optimum
1	pI Value
1	Protein Variants
1	Reaction
5	Reference
7	Source Tissue
10	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name

IC50 Value

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IC50 Value on EC 2.5.1.74 - 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0012

(R)-1-(4-((3-((4-chlorophenyl)(methoxyimino)methyl)phenoxy)-methyl)piperidin-1-yl)octan-2-yl carbamate

Mycobacterium tuberculosis

-

pH 8.0, 37°C

722920

0.0015

(R)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)-octan-2-yl carbamate

Mycobacterium tuberculosis

-

pH 8.0, 37°C

722920

0.0035

(S)-(2-chloro-4-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)-phenyl)(4-chlorophenyl)methanone

Mycobacterium tuberculosis

-

pH 8.0, 37°C

722920

0.0015

(S)-1-(4-((3-chloro-4-((4-chlorophenyl)(methoxyimino)methyl)-phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

Mycobacterium tuberculosis

-

pH 8.0, 37°C

722920

0.0015

(S)-1-(4-((3-chloro-4-(4-chlorobenzoyl)phenoxy)methyl)-piperidin-1-yl)octan-2-yl carbamate

Mycobacterium tuberculosis

-

pH 8.0, 37°C

722920