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2.5.1.74: 1,4-dihydroxy-2-naphthoate polyprenyltransferase

This is an abbreviated version!
For detailed information about 1,4-dihydroxy-2-naphthoate polyprenyltransferase, go to the full flat file.

Reaction

an all-trans-polyprenyl diphosphate
+
1,4-dihydroxy-2-naphthoate
=
a demethylmenaquinol
+
diphosphate
+
CO2

Synonyms

1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenA

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase

Reference

Reference on EC 2.5.1.74 - 1,4-dihydroxy-2-naphthoate polyprenyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shineberg, B.; Young, I.G.
Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli
Biochemistry
15
2754-2758
1976
Escherichia coli
Manually annotated by BRENDA team
Suvarna, K.; Stevenson, D.; Meganathan, R.; Hudspeth, M.E.S.
Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli
J. Bacteriol.
180
2782-2787
1998
Escherichia coli (P32166)
Manually annotated by BRENDA team
Saito, Y.; Ogura, K.
Biosynthesis of menaquinones. Enzymic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions
J. Biochem.
89
1445-1452
1981
Micrococcus luteus
Manually annotated by BRENDA team
Debnath, J.; Siricilla, S.; Wan, B.; Crick, D.C.; Lenaerts, A.J.; Franzblau, S.G.; Kurosu, M.
Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis
J. Med. Chem.
55
3739-3755
2012
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Liao, Y.F.; Wang, Y.; Huang, Y.; Zha, S.F.; Liu, J.J.; Wang, Z.K.; Yin, Y.P.; Liao, Y.F.; Wang, Y.
Isolation and functional analysis of McMenA, a gene encoding a 1,4-dihydroxy-2-naphthoate octaprenyltransferase in Mylabris cichorii
Arch. Insect Biochem. Physiol.
89
127-137
2015
Mylabris cichorii (A0A0U1XZ37), Mylabris cichorii
Manually annotated by BRENDA team