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2.5.1.81: geranylfarnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about geranylfarnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.81

Reaction

geranylgeranyl diphosphate
+
isopentenyl diphosphate
=
(2E,6E,10E,14E)-geranylfarnesyl diphosphate
 +
diphosphate

Synonyms

AtIDS1, AtIDS10, AtIDS6, AtIDS7, AtIDS9, C25 farnesylgeranyl diphosphate synthase, C25 FGPP synthase, farnesyl diphosphate synthase, farnesylgeranyl diphosphate synthase, FGPP synthase, Fgs, GFDP synthase, GFDP-forming enzyme, GFDPS, GFPS, IDS3, Lc-GFDPS, MM_0789

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.81 geranylfarnesyl diphosphate synthase

Engineering

Engineering on EC 2.5.1.81 - geranylfarnesyl diphosphate synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S175M
D109A
mutation leads to the production of longer prenyl diphosphates from C30 to C35, but at small rates
I112A
chain length of the products of mutant I112A reaches up to C70 or longer, which is three times as long as that of the wild type. A large fraction of the longer products is C45-50, which is nearly twice as long as wild-type
II116A
mutation leads to the production of longer prenyl diphosphates from C30 to C35, but at small rates
M137A
slight increase in chain length of products
M72A
slight increase in chain length of products
additional information