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2.5.1.82: hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

This is an abbreviated version!
For detailed information about hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific], go to the full flat file.

Reaction

geranylgeranyl diphosphate
+ 2 isopentenyl diphosphate = 2 diphosphate +
all-trans-hexaprenyl diphosphate

Synonyms

(all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, EC 2.5.1.33, hexaprenyl pyrophosphate synthase, HexPPs, HexPS

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

Crystallization

Crystallization on EC 2.5.1.82 - hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
D81C and W136E mutant crystals are grown at room temperature by the hanging drop vapor diffusion method from a reservoir solution containing 10% (w/v) polyethyleneglycol 8000, 2.4 M lithium chloride, and 100 mM Tris (pH 8.0). Crystal structure of the homodimeric C30-HexPPs resembles those of other trans-prenyltransferases, including farnesyl pyrophosphate synthase (FPPs) and octaprenyl pyrophosphate synthase