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2.5.1.83: hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

This is an abbreviated version!
For detailed information about hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific], go to the full flat file.

Reaction

(2E,6E)-farnesyl diphosphate
+ 3 isopentenyl diphosphate = 3 diphosphate +
all-trans-hexaprenyl diphosphate

Synonyms

C30PP synthase, COQ1, Coq1p, EC 2.5.1.33, hexaprenyl pyrophosphate synthetase, hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific], HexPP synthase, HexPPs, HexPS

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.83 hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

Reference

Reference on EC 2.5.1.83 - hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujii, H.; Koyama, T.; Ogura, K.
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components
J. Biol. Chem.
257
14610-14612
1982
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129), Micrococcus luteus B-P 26
Manually annotated by BRENDA team
Yoshida, I.; Koyama, T.; Ogura, K.
Formation of a stable and catalytically active complex of the two essential components of hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26
Biochem. Biophys. Res. Commun.
160
448-452
1989
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129)
Manually annotated by BRENDA team
Yoshida, I.; Koyama, T.; Ogura, K.
Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents
Biochim. Biophys. Acta
995
138-143
1989
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129)
Manually annotated by BRENDA team
Shimizu, N.; Koyama, T.; Ogura, K.
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase
J. Bacteriol.
180
1578-1581
1998
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129)
Manually annotated by BRENDA team
Nagaki, M.; Kimura, K.; Kimura, H.; Maki, Y.; Goto, E.; Nishino, T.; Koyama, T.
Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases
Bioorg. Med. Chem. Lett.
11
2157-2159
2001
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129)
Manually annotated by BRENDA team
Nagaki, M.; Miki, Y.; Nakada, M.; Kawakami, J.; Kitahara, H.; Maki, Y.; Gotoh, Y.; Nishino, T.; Koyama, T.
Substrate specificities of several prenyl chain elongating enzymes with respect to 4-methyl-4-pentenyl diphosphate
Biosci. Biotechnol. Biochem.
68
2070-2075
2004
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129)
Manually annotated by BRENDA team
Yoshida, I.; Koyama, T.; Ogura, K.
Dynamic Interaction between Components of Hexaprenyl Diphosphate Synthase from Micrococcus luteus BP-26
Biochemistry
26
6840-6845
1987
Micrococcus luteus (O66127 and O66129), Micrococcus luteus BP-26 (O66127 and O66129)
Manually annotated by BRENDA team
Zhang, Y.W.; Li, X.Y.; Koyama, T.
Chain length determination of prenyltransferases: both heteromeric subunits of medium-chain (E)-prenyl diphosphate synthase are involved in the product chain length determination
Biochemistry
39
12717-12722
2000
Micrococcus luteus (O66127 and O66129), Micrococcus luteus B-P 26 (O66127 and O66129)
Manually annotated by BRENDA team
Sasaki, D.; Fujihashi, M.; Okuyama, N.; Kobayashi, Y.; Noike, M.; Koyama, T.; Miki, K.
Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation
J. Biol. Chem.
286
3729-3740
2011
Micrococcus luteus (O66129 and O66127), Micrococcus luteus B-P 26 (O66129 and O66127)
Manually annotated by BRENDA team
Li, L.; Furubayashi, M.; Hosoi, T.; Seki, T.; Otani, Y.; Kawai-Noma, S.; Saito, K.; Umeno, D.
Construction of a nonnatural C60 carotenoid biosynthetic pathway
ACS Synth. Biol.
8
511-520
2019
Micrococcus luteus
Manually annotated by BRENDA team
Camesasca, L.; Minteguiaga, M.; Farina, L.; Salzman, V.; Aguilar, P.S.; Gaggero, C.; Carrau, F.
Overproduction of isoprenoids by Saccharomyces cerevisiae in a synthetic grape juice medium in the absence of plant genes
Int. J. Food Microbiol.
282
42-48
2018
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4743
Manually annotated by BRENDA team