2.5.1.86: trans,polycis-decaprenyl diphosphate synthase

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For detailed information about trans,polycis-decaprenyl diphosphate synthase, go to the full flat file.

Reaction

Synonyms

cis-decaprenyl diphosphate synthase, decaprenyl diphosphate synthase, decaprenyl diphosphate synthase 1, decaprenyl diphosphate synthase 2, DPP synthase, DPPS, DPS1, long-chain prenyl diphosphate synthase, MtDPPS, polyprenyl diphosphate synthase, Rv2361c, SlDPS, Z-decaprenyl-diphosphate synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.86 trans,polycis-decaprenyl diphosphate synthase

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Results	in table
2	Activating Compound
13	AA Sequence
2	Application
13	Cloned(Commentary)
5	Crystallization (Commentary)
15	General Information
1	IC50 Value
2	Inhibitors
5	kcat/KM [mM/s]
6	KM Value [mM]
3	Localization
10	Metals/Ions
1	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
44	Organism
5	Pathway
4	PDB ID
2	pH Optimum
2	pI Value
3	Protein Variants
3	Purification (Commentary)
3	Reaction
22	Reference
40	Substrates and Products (Substrate)
10	Subunits
46	Synonyms
1	Systematic Name
6	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.5.1.86 - trans,polycis-decaprenyl diphosphate synthase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystallization using sparse matrix screens and vapor diffusion, structures of Rv2361c in the apo form, with isopentyl diphosphate bound and with a substrate analogue, citronellyl diphosphate

Mycobacterium tuberculosis

P9WFF7

705121

enzyme in complex with the substrate analogues geranyl S-thiodiphosphate and isopentenyl S-thiodiphosphate, sitting drop vapor diffusion method, using 0.1 M HEPES pH 7.5, 10% (v/v) glycerol, 25% (w/v) PEG 400, 7% (w/v) PEG 3000

Mycobacterium tuberculosis

P9WFF7

758604

in complex with BPH-640, hanging drop vapor diffusion method, using

Mycobacterium tuberculosis

P9WFF7

729897

purified recombinant enzyme in complex with inhibitor BPH-640, X-ray diffraction structure determination and analysis at 1.8-1.9 A resolution

Mycobacterium tuberculosis

P9WFF7

729897

sitting-drop vapour-diffusion method at 25°C. A 1.55 A resolution structure of the enzyme in complex with the substrate analogues geranyl S-thiodiphosphate and isopentenyl S-thiodiphosphate bound to their respective sites in one subunit shows the active-site configuration and the magnesium-coordinated geometry for catalysis

Mycobacterium tuberculosis

P9WFF7

758604