2.5.1.86: trans,polycis-decaprenyl diphosphate synthase
This is an abbreviated version!
For detailed information about trans,polycis-decaprenyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.86
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2.5.1.86
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ubiquinone
-
isoprenoid
-
prenylation
-
isoprene
-
geranyl
-
octaprenyl
-
solanesyl
-
prenyltransferases
-
ubiquinone-10
-
gluconobacter
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suboxydans
-
corticorubral
-
rubrospinal
-
1-deoxy-d-xylulose
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drug development
- 2.5.1.86
- ubiquinone
-
isoprenoid
-
prenylation
- isoprene
-
geranyl
-
octaprenyl
-
solanesyl
- prenyltransferases
- ubiquinone-10
-
gluconobacter
- suboxydans
-
corticorubral
-
rubrospinal
- 1-deoxy-d-xylulose
- drug development
Reaction
Synonyms
cis-decaprenyl diphosphate synthase, decaprenyl diphosphate synthase, decaprenyl diphosphate synthase 1, decaprenyl diphosphate synthase 2, DPP synthase, DPPS, DPS1, long-chain prenyl diphosphate synthase, MtDPPS, polyprenyl diphosphate synthase, Rv2361c, SlDPS, Z-decaprenyl-diphosphate synthase
ECTree
2.5.1.86 trans,polycis-decaprenyl diphosphate synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.5.1.86 - trans,polycis-decaprenyl diphosphate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
(2Z,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + trans,octacis-decaprenyl diphosphate
geranyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
geranylgeranyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + octaprenyl diphosphate + nonaprenyl diphosphate
-
the major product synthesized is octaprenyl diphosphate, followed by nonaprenyl diphosphate, decaprenyl diphosphate, and heptaprenyl diphosphate
-
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
-
decaprenyl diphosphate, nonaprenyl diphosphate, and octaprenyl diphosphate are synthesized. The relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
-
the relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate. Shorter chain length also produced. As the concentration of (2Z,6E)-farnesyl diphosphate is increased in the assays, there is an increase in the amount of the shorter products synthesized relative to decaprenyl diphosphate
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
-
the relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate. Shorter chain length also produced. As the concentration of (2Z,6E)-farnesyl diphosphate is increased in the assays, there is an increase in the amount of the shorter products synthesized relative to decaprenyl diphosphate
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor, suggesting that this is the natural substrate in vivo
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
(2Z,6E)-farnesyl diphosphate i.e. omega, E,Z-farnesyl diphosphate, the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor
decaprenyl diphosphate is the predominant product synthesized, smaller amounts of intermediates of intermediates of shorter chain lengths also being produced. The amount of 40-carbon and 45-carbon products relative to 50-carbon products increases as the (2Z,6E)-farnesyl diphosphate concentration is increased, suggesting that the enzyme loses specificity as the substrate concentration increases
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor, suggesting that this is the natural substrate in vivo
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
(2Z,6E)-farnesyl diphosphate i.e. omega, E,Z-farnesyl diphosphate, the catalytic efficiency is greatest when (2Z,6E)-farnesyl diphosphate is used as the allylic acceptor
decaprenyl diphosphate is the predominant product synthesized, smaller amounts of intermediates of intermediates of shorter chain lengths also being produced. The amount of 40-carbon and 45-carbon products relative to 50-carbon products increases as the (2Z,6E)-farnesyl diphosphate concentration is increased, suggesting that the enzyme loses specificity as the substrate concentration increases
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
the enzyme is involved in decaprenyl phosphate synthesis, that is important in the rate of bacterial growth and the synthesis of cell wall components
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
enzyme DPPS accepts farnesyl diphosphate but not dimethylallyl diphosphate as the allylic co-substrate
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
Bullera alba NBRC 1192
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
Cystobasidium minutum NBRC 0387
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
the enzyme is a cis-prenyl transferase
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
the enzyme is a cis-prenyl transferase
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + trans,octacis-decaprenyl diphosphate
-
enzyme SlDPS extends the prenyl chain length of the endogenous ubiquinone to ten isoprene units
-
-
?
(2Z,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
(2Z,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
-
?
(2Z,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + trans,octacis-decaprenyl diphosphate
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
-
decaprenyl diphosphate, nonaprenyl diphosphate, and octaprenyl diphosphate are synthesized. The relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + decaprenyl diphosphate + nonaprenyl diphosphate + octaprenyl diphosphate
-
decaprenyl diphosphate, nonaprenyl diphosphate, and octaprenyl diphosphate are synthesized. The relative amounts of both decaprenyl diphosphate and octaprenyl diphosphate are greater than that of nonaprenyl diphosphate
-
?
additional information
?
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product identification by GCMS analysis
-
-
?
additional information
?
-
product identification by GCMS analysis
-
-
?
additional information
?
-
the enzyme is not strictly specific for either the chain length or stereoconfiguration of the acceptor. No activity with dimethylallyl diphosphate
-
-
?
additional information
?
-
-
the enzyme is not strictly specific for either the chain length or stereoconfiguration of the acceptor. No activity with dimethylallyl diphosphate
-
-
?
additional information
?
-
the enzyme is not strictly specific for either the chain length or stereoconfiguration of the acceptor. No activity with dimethylallyl diphosphate
-
-
?
additional information
?
-
-
the enzyme is not strictly specific for either the chain length or stereoconfiguration of the acceptor. No activity with dimethylallyl diphosphate
-
-
?
additional information
?
-
-
the enzyme can utilize geranyl, farnesyl or geranylgeranyl diphosphates in the synthesis of C45 and C50 prenyl diphosphates
-
-
?
