2.5.1.9: riboflavin synthase

This is an abbreviated version!
For detailed information about riboflavin synthase, go to the full flat file.

Reaction

2 6,7-dimethyl-8-(1-D-ribityl)lumazine =

Synonyms

heavy riboflavin synthase, light riboflavin synthase, lumazine synthase/riboflavin synthase complex, RibD, RibE1, riboflavin synthase, riboflavin synthetase, riboflavine synthase, riboflavine synthetase, synthase, riboflavin

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.9 riboflavin synthase

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Results	in table
14	Activating Compound
18084	AA Sequence
6	Application
1	CAS Registry Number
18	Cloned(Commentary)
1	Cofactor
10	Crystallization (Commentary)
3	Expression
5	General Information
5	General Stability
11	IC50 Value
130	Inhibitors
63	Ki Value [mM]
16	KM Value [mM]
5	Metals/Ions
28	Molecular Weight [Da]
75	Natural Substrates/ Products (Substrates)
268	Organism
1	Oxidation Stability
8	Pathway
93	PDB ID
20	pH Optimum
2	pH Range
4	pH Stability
39	Protein Variants
21	Purification (Commentary)
30	Reaction
1	Reaction Type
88	Reference
14	Source Tissue
38	Specific Activity [micromol/min/mg]
8	Storage Stability
128	Substrates and Products (Substrate)
36	Subunits
17	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.5.1.9 - riboflavin synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.02964

(2-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl 3,4,5-triethoxybenzoate

Brucella abortus

-

pH 7.5, 37°C

759180

0.01915

(2E)-3-(2,3-dimethoxyphenyl)-N-[4-methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]prop-2-enamide

Brucella abortus

-

pH 7.5, 37°C

759180

0.02564

2-(4-ethoxyphenyl)-N-[3-(piperidin-1-yl)propyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxamide

Brucella abortus

-

pH 7.5, 37°C

759180

0.03118

2-(4-methoxyphenyl)-N-[3-(piperidin-1-yl)propyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxamide

Brucella abortus

-

pH 7.5, 37°C

759180

0.00235

2-[ethyl(methyl)amino]ethyl 4-[(5-ethyl-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carbonyl)amino]benzoate

Brucella abortus

-

pH 7.5, 37°C

759180

0.03053

5-[3-(propan-2-yl)-1H-pyrazol-5-yl]-3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole

Brucella abortus

-

pH 7.5, 37°C

759180

0.01912

ethyl 5-(diethylcarbamoyl)-2-[2-(4-methoxyphenoxy)acetamido]-4-methylthiophene-3-carboxylate

Brucella abortus

-

pH 7.5, 37°C

759180

0.0000013

N-[2,4-dioxo-6-(ribitylamino)-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid ethyl ester

Escherichia coli

-

pH 7.0, 27°C

688578

0.02638

N-[3-(azepan-1-yl)propyl]-2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxamide

Brucella abortus

-

pH 7.5, 37°C

759180

0.0278

N-[3-(diethylamino)propyl]-2-(4-ethoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxamide

Brucella abortus

-

pH 7.5, 37°C

759180

0.03187

N-[3-(diethylamino)propyl]-2-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxamide

Brucella abortus

-

pH 7.5, 37°C

759180