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2.5.1.90: all-trans-octaprenyl-diphosphate synthase

This is an abbreviated version!
For detailed information about all-trans-octaprenyl-diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.90

Reaction

(2E,6E)-farnesyl diphosphate
+ 5 isopentenyl diphosphate = 5 diphosphate +
all-trans-octaprenyl diphosphate

Synonyms

C40-OPP, cel, gbs1789, IspB, long-chain C40 octaprenyl diphosphate synthase, long-chain trans-prenyltransferase, octaprenyl diphosphate synthase, octaprenyl pyrophosphate, octaprenyl pyrophosphate synthase, octaprenyl-diphosphate synthase, Opp, OPP synthase, OPP synthetase, OPPs, trans-prenyltransferase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.90 all-trans-octaprenyl-diphosphate synthase

Reference

Reference on EC 2.5.1.90 - all-trans-octaprenyl-diphosphate synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujisaki, S.; Nishino, T.; Katasuki, H.
Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis
J. Biochem.
99
1327-1337
1986
Escherichia coli K-12 (P0AD57)
Manually annotated by BRENDA team
Kainou, T.; Okada, K.; Suzuki, K.; Nakagawa, T.; Matsuda, H.; Kawamukai, M.
Dimer formation of octaprenyl-diphosphate synthase (IspB) is essential for chain length determination of ubiquinone
J. Biol. Chem.
276
7876-7883
2001
Escherichia coli K-12 (P0AD57)
Manually annotated by BRENDA team
Asai, K.; Fujisaki, S.; Nishimura, Y.; Nishino, T.; Okada, K.; Nakagawa, T.; Kawamukai, M.; Matsuda, H.
The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase
Biochem. Biophys. Res. Commun.
202
340-345
1994
Escherichia coli
Manually annotated by BRENDA team
Cui, T.Z.; Kaino, T.; Kawamukai, M.
A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex
FEBS Lett.
584
652-656
2010
Schizosaccharomyces pombe
Manually annotated by BRENDA team
Okada, K.; Minehira, M.; Zhu, X.; Suzuki, K.; Nakagawa, T.; Matsuda, H.; Kawamukai, M.
The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli
J. Bacteriol.
179
3058-3060
1997
Escherichia coli K-12 (P0AD57), Haemophilus influenzae (P44916), Haemophilus influenzae, Synechocystis sp. PCC 6803
Manually annotated by BRENDA team
Guo, R.T.; Kuo, C.J.; Chou, C.C.; Ko, T.P.; Shr, H.L.; Liang, P.H.; Wang, A.H.
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination
J. Biol. Chem.
279
4903-4912
2004
Thermotoga maritima (Q9X1M1), Thermotoga maritima
Manually annotated by BRENDA team
Choi, J.-H.; Ryu, Y.-W.; Park, Y.-C.; Seo, J.-H.
Synergistic effects of chromosomal ispB deletion and dxs overexpression on coenzyme Q10 production in recombinant Escherichia coli expressing Agrobacterium tumefaciens dps gene
J. Biotechnol.
144
64-69
2009
Escherichia coli (P0AD57), Escherichia coli
Manually annotated by BRENDA team
Lu, Y.P.; Liu, H.G.; Liang, P.H.
Different reaction mechanisms for cis- and trans-prenyltransferases
Biochem. Biophys. Res. Commun.
379
351-355
2009
Escherichia coli
Manually annotated by BRENDA team
Tonhosolo, R.; D'Alexandri, F.L.; Genta, F.A.; Wunderlich, G.; Gozzo, F.C.; Eberlin, M.N.; Peres, V.J.; Kimura, E.A.; Katzin, A.M.
Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum
Biochem. J.
392
117-126
2005
Plasmodium falciparum (O96130), Plasmodium falciparum
Manually annotated by BRENDA team
Guo, R.-T.; Kuo, C.-J.; Ko, T.-P.; Chou, C.-C.; Liang, P.-H.; Wang, A.H.J.
A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products
Biochemistry
43
7678-7686
2004
Thermotoga maritima (Q9X1M1), Thermotoga maritima
Manually annotated by BRENDA team
Pan, J.-J.; Kuo, T.-H.; Chen, Y.-K.; Yang, L.-W.; Liang, P.-H.
Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis
Biochim. Biophys. Acta
1594
64-73
2002
Escherichia coli
Manually annotated by BRENDA team
Kuo, T.-H.; Liang, P.-H.
Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzyme
Biochim. Biophys. Acta
1599
125-133
2002
Thermotoga maritima
Manually annotated by BRENDA team
Chang, K.; Chen, S.; Kuo, C.; Chang, C.; Guo, R.; Yang, J.; Liang, P.
Roles of amino acids in the Escherichia coli octaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis
Biochemistry
51
3412-3419
2012
Escherichia coli (P0AD57), Escherichia coli
Manually annotated by BRENDA team
Zhang, J.; Zhang, X.; Zhang, R.; Wu, C.; Guo, Y.; Mao, X.; Guo, G.; Zhang, Y.; Wang, D.C.; Li, D.; Zou, Q.
Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases
Int. J. Biochem. Cell Biol.
44
2116-2123
2012
Helicobacter pylori (O25023), Helicobacter pylori
Manually annotated by BRENDA team
Li, X.; Han, X.; Ko, T.P.; Chen, C.C.; Zhu, Z.; Hua, E.; Guo, R.T.; Huang, C.H.
Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli
Acta Crystallogr. Sect. F
69
328-331
2013
Escherichia coli (P0AD57), Escherichia coli
Manually annotated by BRENDA team
Franza, T.; Delavenne, E.; Derre-Bobillot, A.; Juillard, V.; Boulay, M.; Demey, E.; Vinh, J.; Lamberet, G.; Gaudu, P.
A partial metabolic pathway enables group b Streptococcus to overcome quinone deficiency in a host bacterial community
Mol. Microbiol.
102
81-91
2016
Streptococcus agalactiae serogroup III (Q8E3H0), Streptococcus agalactiae serogroup III NEM316 (Q8E3H0)
Manually annotated by BRENDA team
Han, X.; Chen, C.C.; Kuo, C.J.; Huang, C.H.; Zheng, Y.; Ko, T.P.; Zhu, Z.; Feng, X.; Wang, K.; Oldfield, E.; Wang, A.H.; Liang, P.H.; Guo, R.T.; Ma, Y.
Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms
Proteins
83
37-45
2015
Escherichia coli (P0AD57), Escherichia coli
Manually annotated by BRENDA team
Kuo, T.; Liang, P.
Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima How is it different from that of the mesophilic enzyme
Biochim. Biophys. Acta
1599
125-133
2002
Thermotoga maritima (Q9X1M1), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X1M1)
Manually annotated by BRENDA team
Teng, K.H.; Hsu, E.T.; Chang, Y.H.; Lin, S.W.; Liang, P.H.
Fluorescent farnesyl diphosphate analogue A probe to validate trans-prenyltransferase inhibitors
Biochemistry
55
4366-4374
2016
Escherichia coli (P0AD57)
Manually annotated by BRENDA team
Takahashi, H.; Aihara, Y.; Ogawa, Y.; Murata, Y.; Nakajima, K.I.; Iida, M.; Shirai, M.; Fujisaki, S.
Suppression of phenotype of Escherichia coli mutant defective in farnesyl diphosphate synthase by overexpression of gene for octaprenyl diphosphate synthase
Biosci. Biotechnol. Biochem.
82
1003-1010
2018
Escherichia coli (P0AD57), Escherichia coli, Escherichia coli K12 (P0AD57)
Manually annotated by BRENDA team
Inokoshi, J.; Nakamura, Y.; Komada, S.; Komatsu, K.; Umeyama, H.; Tomoda, H.
Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules
J. Antibiot.
69
798-805
2016
Escherichia coli
Manually annotated by BRENDA team