2.5.1.92: (2Z,6Z)-farnesyl diphosphate synthase
This is an abbreviated version!
For detailed information about (2Z,6Z)-farnesyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.92
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2.5.1.92
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neryl
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terpene
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tomato
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trichomes
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longer-chain
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rnai-mediated
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thermococcus
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kodakaraensis
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cis-prenyltransferases
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lycopersicum
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solanum
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sesquiterpenes
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drug development
- 2.5.1.92
-
neryl
-
terpene
- tomato
-
trichomes
-
longer-chain
-
rnai-mediated
-
thermococcus
- kodakaraensis
- cis-prenyltransferases
- lycopersicum
- solanum
-
sesquiterpenes
- drug development
Reaction
Synonyms
cis,cis-farnesyl diphosphate synthase, cis-prenyltransferase, CPT1, FPPase, IDS3, More, short-chain cis-prenyldiphosphate synthase, short-chain SlCPT, SlCPT6, trans-isoprenyl diphosphate synthase, Z,Z-farnesyl diphosphate synthase, Z,Z-farnesyl pyrophosphate synthase, Z,Z-FPP synthase, zFPS
ECTree
2.5.1.92 (2Z,6Z)-farnesyl diphosphate synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.5.1.92 - (2Z,6Z)-farnesyl diphosphate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dimethylallyl diphosphate + 2 isopentenyl diphosphate
(2Z,6Z)-farnesyl diphosphate + 2 diphosphate
head-to-middle condensation function is observed in the N-terminal truncated enzyme. High substrate specificity is demonstrated in this enzyme as the irregular function only occurs without the presence of isopentenyl diphosphate
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-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
neryl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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the product farnesyl diphosphate is an important precursor in the isoprenoid synthesis pathway
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-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
?
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
positive cooperativity for the binding of the enzyme to isopentenyl diphosphate
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-
?
neryl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
?
neryl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
neryl diphosphate is the preferred acceptor substrate
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-
?
neryl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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-
-
?
neryl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
neryl diphosphate is the preferred acceptor substrate
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-
?
additional information
?
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a bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase exists in Plasmodium falciparum
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-
?
additional information
?
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the enzyme also performs the synthesis of (2E,6E)-farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, reaction of EC 2.5.1.10, and of geranylgeranyl diphosphate from (2E,6E)-farnesyl diphosphate and isopentenyl diphosphate, reaction of EC 2.5.1.29. Product identification by thin layer chromatography and mass spectrometry
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?
additional information
?
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a bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase exists in Plasmodium falciparum
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?
additional information
?
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the enzyme also performs the synthesis of (2E,6E)-farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, reaction of EC 2.5.1.10, and of geranylgeranyl diphosphate from (2E,6E)-farnesyl diphosphate and isopentenyl diphosphate, reaction of EC 2.5.1.29. Product identification by thin layer chromatography and mass spectrometry
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-
?
additional information
?
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the relative positioning of aromatic amino acid residues at positions 100 and 107 determines the ability of these enzymes to synthesize neryl diphosphate or (2Z,6Z)-farnesyl diphosphate
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?
additional information
?
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product analysis by radio-TLC and GC-MS
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?
additional information
?
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product analysis by radio-TLC and GC-MS
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?
additional information
?
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product analysis by radio-TLC and GC-MS
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?
