2.6.1.100: L-glutamine:2-deoxy-scyllo-inosose aminotransferase
This is an abbreviated version!
For detailed information about L-glutamine:2-deoxy-scyllo-inosose aminotransferase, go to the full flat file.
Word Map on EC 2.6.1.100
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2.6.1.100
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2-deoxystreptamine
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neomycin
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fradiae
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aminoglycoside
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tobramycin
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self-complementation
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cosmid
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kanamyceticus
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tenebrarius
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2-deoxystreptamine-containing
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butirosin
- 2.6.1.100
- 2-deoxystreptamine
- neomycin
- fradiae
- aminoglycoside
- tobramycin
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self-complementation
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cosmid
- kanamyceticus
- tenebrarius
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2-deoxystreptamine-containing
- butirosin
Reaction
Synonyms
2-deoxy-scyllo-inosose aminotransferase, btrR, BtrS, kanB, L-glutamine:DOI aminotransferase, neo-6, Neo6, neoB, tbmB
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General Information
General Information on EC 2.6.1.100 - L-glutamine:2-deoxy-scyllo-inosose aminotransferase
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evolution
BtrR has a fold characteristic of the aspartate aminotransferase family and is a member of the class of aminotransferases that function primarily in the biosynthesis of secondary metabolites, SMAT, i.e. the secondary metabolite aminotransferases subfamily
malfunction
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disruption mutant strain HN4 is completey devoid of neomycin production
metabolism
physiological function
additional information
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Neo-6 is the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis. Neo-6 also catalyses the amino transfer from L-glutamine to 3-amino-2,3-dideoxy-scyllo-inosose to produce 2-deoxystrepamine, EC 2.6.1.101, the aglycon in neomycins, overview
metabolism
the aminotransferase BtrR is involved in the biosynthesis of butirosin
metabolism
the enzyme catalyses the transamination of 2-deoxy-scyllo-inosose to give 2-deoxy-scyllo-inosamine, an intermediate in the biosynthesis of 2-deoxystreptamine, biosynthetic pathway of 2-deoxystreptamine, overview
metabolism
the enzyme is involved in the biosynthesis of 2-deoxystreptamine (DOS)-containing aminoglycoside neomycin. NeoB also shows L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase activity resulting in formation of 2-deoxy-streptamine, EC 2.6.1.101
metabolism
the enzyme is involved in the biosynthesis of kanamycin
metabolism
the enzyme is involved in the biosynthesis of neomycin
metabolism
the enzyme is involved in the biosynthesis of ribostamycin
metabolism
the enzyme is involved in tobramycin biosynthesis catalyzing the second step of the 2-deoxystreptamine biosynthetic pathway, 2-deoxystreptamine is a subunit of tobramycin, overview
metabolism
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the enzyme is involved in the biosynthesis of ribostamycin
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metabolism
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the enzyme is involved in the biosynthesis of kanamycin
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metabolism
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Neo-6 is the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis. Neo-6 also catalyses the amino transfer from L-glutamine to 3-amino-2,3-dideoxy-scyllo-inosose to produce 2-deoxystrepamine, EC 2.6.1.101, the aglycon in neomycins, overview
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metabolism
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the enzyme is involved in the biosynthesis of 2-deoxystreptamine (DOS)-containing aminoglycoside neomycin. NeoB also shows L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase activity resulting in formation of 2-deoxy-streptamine, EC 2.6.1.101
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metabolism
Niallia circulans NRRL B3312
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the enzyme catalyses the transamination of 2-deoxy-scyllo-inosose to give 2-deoxy-scyllo-inosamine, an intermediate in the biosynthesis of 2-deoxystreptamine, biosynthetic pathway of 2-deoxystreptamine, overview
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BtrR catalyzes the synthesis of 2-deoxystreptamine, which is the common aglycone of a class of aminoglycoside antibiotics, of which many are clinically important aminoglycosides like kanamycin, neomycin, gentamicin and butirosin
physiological function
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kanB functions as 2-deoxy-scyllo-inosose aminotransferase that has dual functions in the formation of 2-deoxy-scyllo-inosose
physiological function
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neo6 functions as 2-deoxy-scyllo-inosose aminotransferase that has dual functions in the formation of 2-deoxy-scyllo-inosose
physiological function
the aminotransferase BtrR is involved in the biosynthesis of butirosin, a 2-deoxystreptamine-containing aminoglycoside antibiotic produced by Bacillus circulans, catalyzing the pyridoxal 5'-phosphate-dependent transamination reaction both of 2-deoxy-scylloinosose to 2-deoxy-scyllo-inosamine and of amino-dideoxy-scyllo-inosose to 2-deoxystreptamine, cf. EC 2.6.1.101
physiological function
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the enzyme produces 2-deoxystreptamine (DOS), EC 2.6.1.101, which is the aglycone in neomycins, overview. Neo-6 is also the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis
physiological function
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the enzyme produces 2-deoxystreptamine (DOS), EC 2.6.1.101, which is the aglycone in neomycins, overview. Neo-6 is also the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis
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physiological function
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kanB functions as 2-deoxy-scyllo-inosose aminotransferase that has dual functions in the formation of 2-deoxy-scyllo-inosose
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physiological function
Niallia circulans NRRL B3312
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BtrR catalyzes the synthesis of 2-deoxystreptamine, which is the common aglycone of a class of aminoglycoside antibiotics, of which many are clinically important aminoglycosides like kanamycin, neomycin, gentamicin and butirosin
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active site structure of BtrR, homodimer with two active sites per dimer, BtrR with bound pyridoxamine 5'-phosphate lacks the covalent bond to Lys192. The active site of the BtrR protomer is located in a cleft between an alpha-helical N-terminus, a central alphabetaalpha-sandwich domain and an alphabeta-C-terminal domain
additional information
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gene neo6 of the neo gene cluster and btrR from the btr gene cluster are equivalent, genetic organization, overview
additional information
the equivalent of gene neoB, from neo gene cluster, in the btr gene cluster is gene btrS
additional information
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the equivalent of gene neoB, from neo gene cluster, in the btr gene cluster is gene btrS
additional information
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gene neo6 of the neo gene cluster and btrR from the btr gene cluster are equivalent, genetic organization, overview
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additional information
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the equivalent of gene neoB, from neo gene cluster, in the btr gene cluster is gene btrS
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