2.6.1.109: 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase
This is an abbreviated version!
For detailed information about 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase, go to the full flat file.
Reaction
Synonyms
kdnA
ECTree
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Substrates Products
Substrates Products on EC 2.6.1.109 - 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase
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REACTION DIAGRAM
8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
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i.e. Kdo
i.e. Kdo8N, i.e. Kdo8N, the D-manno-configuration of the monosaccharide is determined by Mosher ester method, absolute configuration is 4R,5R,6R,7R, NMR spectrometry, overview
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?
8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
Shewanella japonica KMM 3772
-
i.e. Kdo
i.e. Kdo8N, i.e. Kdo8N, the D-manno-configuration of the monosaccharide is determined by Mosher ester method, absolute configuration is 4R,5R,6R,7R, NMR spectrometry, overview
-
?
8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
i.e. Kdo
i.e. Kdo8N
-
?
8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
i.e. Kdo, direct conversion of Kdo to Kdo8N prior to its incorporation into the Kdo8N-lipid A domain of lipopolysaccharide by a metal-dependent oxidase KdnB, EC 1.1.3.48, followed by a glutamate-dependent aminotransferase KdnA, EC 2.3.1.09, the electron acceptor is molecular oxygen
i.e. Kdo8N
-
?
8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
Shewanella oneidensis MR-1 / ATCC 700550
i.e. Kdo
i.e. Kdo8N
-
?
8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate
8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
Shewanella oneidensis MR-1 / ATCC 700550
i.e. Kdo, direct conversion of Kdo to Kdo8N prior to its incorporation into the Kdo8N-lipid A domain of lipopolysaccharide by a metal-dependent oxidase KdnB, EC 1.1.3.48, followed by a glutamate-dependent aminotransferase KdnA, EC 2.3.1.09, the electron acceptor is molecular oxygen
i.e. Kdo8N
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?
?
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the reaction catalyzed by KdnB, EC 1.1.3.48, is thermodynamically unfavorable and requires the second reaction catalyzed by KdnA to drive product formation, both enzymes are required for product formation. Production of H2O2 when Mn-KdnB and PLP-KdnA are incubated with Kdo and L-Glu
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-
?
additional information
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Shewanella oneidensis MR-1 / ATCC 700550
the reaction catalyzed by KdnB, EC 1.1.3.48, is thermodynamically unfavorable and requires the second reaction catalyzed by KdnA to drive product formation, both enzymes are required for product formation. Production of H2O2 when Mn-KdnB and PLP-KdnA are incubated with Kdo and L-Glu
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-
?