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2.6.1.12: alanine-oxo-acid transaminase

This is an abbreviated version!
For detailed information about alanine-oxo-acid transaminase, go to the full flat file.

Reaction

L-alanine
+
a 2-oxo carboxylate
=
pyruvate
+
an L-amino acid

Synonyms

alanine-keto acid aminotransferase, alanine-oxo acid aminotransferase, aminotransferase, alanine-keto acid, L-alanine-alpha-keto acid aminotransferase, leucine-alanine transaminase

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.12 alanine-oxo-acid transaminase

Substrates Products

Substrates Products on EC 2.6.1.12 - alanine-oxo-acid transaminase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxobutanoate
pyruvate + 2-aminobutanoate
show the reaction diagram
-
-
-
r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
-
at 2% of the activity with 2-oxobutanoate
-
r
L-alanine + 2-oxohexanoate
pyruvate + 2-aminohexanoate
show the reaction diagram
-
at 81% of the activity with 2-oxobutanoate
-
r
L-alanine + 2-oxoisohexanoate
pyruvate + L-leucine
show the reaction diagram
-
at 8% of the activity with 2-oxobutanoate
-
r
L-alanine + 2-oxoisopentanoate
pyruvate + L-valine
show the reaction diagram
-
at 10% of the activity with 2-oxobutanoate
-
r
L-alanine + 2-oxopentanoate
pyruvate + L-norvaline
show the reaction diagram
-
at 108% of the activity with 2-oxobutanoate
-
r
L-alanine + glyoxylate
pyruvate + glycine
show the reaction diagram
-
53% of the activity with 2-oxobutanoate
-
?
L-alanine + oxaloacetate
pyruvate + L-aspartate
show the reaction diagram
-
at 16% of the activity with 2-oxobutanoate
-
r
pyruvate + L-2-aminobutanoate
L-alanine + 2-oxobutanoate
show the reaction diagram
-
preferred amino donor
-
r
pyruvate + L-aspartate
L-alanine + oxaloacetate
show the reaction diagram
-
4% of the activity with L-2-aminobutanoate
-
?
pyruvate + L-glutamate
L-alanine + 2-oxoglutarate
show the reaction diagram
-
4% of the activity with L-2-aminobutanoate
-
r
pyruvate + L-isoleucine
L-alanine + 3-methyl-2-oxopentanoate
show the reaction diagram
pyruvate + L-leucine
alanine + 4-methyl-2-oxopentanoate
show the reaction diagram
pyruvate + L-norleucine
L-alanine + 2-oxohexanoate
show the reaction diagram
pyruvate + L-norvaline
L-alanine + 2-oxopentanoate
show the reaction diagram
-
84% of the activity with L-2-aminobutanoate
-
r
pyruvate + L-phenylalanine
L-alanine + 2-oxo-3-phenylpropanoate
show the reaction diagram
pyruvate + L-threonine
L-alanine + 3-hydroxy-2-oxobutanoate
show the reaction diagram
-
3% of the activity with L-2-aminobutanoate
-
?
pyruvate + L-valine
L-alanine + 3-methyl-2-oxobutanoate
show the reaction diagram
-
8% of the activity with L-2-aminobutanoate
-
r