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2.6.1.13: ornithine aminotransferase

This is an abbreviated version!
For detailed information about ornithine aminotransferase, go to the full flat file.

Word Map on EC 2.6.1.13

Reaction

L-ornithine
+
a 2-oxo carboxylate
=
L-glutamate 5-semialdehyde
+
an L-amino acid

Synonyms

aminotransferase, ornithine-keto acid, delta OAT, delta-OAT, delta-ornithine aminotransferase, deltaOAT, EC 2.6.1.68, hOAT, L-ornithine 5-aminotransferase, L-ornithine aminotransferase, L-ornithine:2-oxoacid aminotransferase, L-ornithine:alpha-ketoglutarate delta-aminotransferase, OAT, Orn-AT, ornithine 5-aminotransferase, ornithine amino transferase, ornithine aminotransferase, ornithine delta aminotransferase, ornithine delta-amino transferase, ornithine delta-aminotransferase, ornithine delta-transaminase, ornithine transaminase, ornithine-2-oxoacid aminotransferase, ornithine-alpha-ketoglutarate aminotransferase, ornithine-delta-aminotransferase, ornithine-keto acid aminotransferase, ornithine-keto acid transaminase, ornithine-ketoglutarate aminotransferase, ornithine-oxo acid aminotransferase, ornithine-oxo-acid transaminase, ornithine: 2-oxo-glutarate aminotransferase, ornithine:alpha-oxoglutarate transaminase, PsOAT, RocD, TaOAT, TaOAT-5AL, TaOAT-5B, TaOAT-5BL, TaOAT-5DL, TaOAT-AL-2, TgOAT

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.13 ornithine aminotransferase

General Stability

General Stability on EC 2.6.1.13 - ornithine aminotransferase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
2-mercaptoethanol or DTT stabilizes
-
activity of the purified enzyme is preserved by addition of pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate is required during solubilization and purification
-
pyridoxal 5'-phosphate slightly increases heat stability
-
pyridoxal 5'-phosphate stabilizes
-
stability enhanced by presence of DTT and glycerol
-
unlike holo-hOAT, apo-hOAT is prone to unfolding and aggregation under physiological conditions. Under physiological conditions the apo-tetramer is slightly less prone to unfolding and aggregation than the apo-dimer