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2.6.1.19: 4-aminobutyrate-2-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about 4-aminobutyrate-2-oxoglutarate transaminase, go to the full flat file.

Word Map on EC 2.6.1.19

Reaction

4-aminobutanoate
+
2-oxoglutarate
=
succinate semialdehyde
 +
L-glutamate

Synonyms

4-aminobutyrate aminotransferase, 4-aminobutyrate transaminase, 4-aminobutyrate-2-ketoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate transaminase, 4-aminobutyric acid 2-ketoglutaric acid aminotransferase, 4-aminobutyric acid aminotransferase, ABAT, aminobutyrate aminotransferase, aminobutyrate transaminase, aminotransferase, aminobutyrate, argD, argD6803, argD7002, Atu3000, beta-alanine aminotransferase, beta-alanine transaminase, beta-alanine-oxoglutarate aminotransferase, beta-alanine-oxoglutarate transaminase, bioA, CG010_026395, CgGABA-AT, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-2-oxoglutarate aminotransferase, GABA-2-oxoglutarate transaminase, GABA-alpha-ketoglutarate aminotransferase, GABA-alpha-ketoglutarate transaminase, GABA-alpha-ketoglutaric acid transaminase, GABA-alpha-oxoglutarate aminotransferase, GABA-AT, GABA-oxoglutarate aminotransferase, GABA-oxoglutarate transaminase, GABA-T, GABA-T1, GABA-T2, GABA-T3, GABA-TA, GABA-transaminase, GABA:2-oxoglutarate aminotransferase, GABAT, GabT, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate aminotransferase, gamma-aminobutyrate transaminase, gamma-aminobutyrate transaminases, gamma-aminobutyrate-alpha-ketoglutarate aminotransferase, gamma-aminobutyrate-alpha-ketoglutarate transaminase, gamma-aminobutyrate: GABA transaminase, gamma-aminobutyrate:alpha-oxoglutarate aminotransferase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric acid-2-oxoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase, gamma-aminobutyric transaminase, gatT, glutamate-succinic semialdehyde transaminase, homotaurine:2-oxoglutarate aminotransferase, MdGABA-T1, MdGABA-T2, More, NCgl0462, NCgl2515, Osl2, pollen-pistil incompatibility 2, Pop2, SkUga1p, slr1022

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase

KI Value

KI Value on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.364
(+/-)piperidine-3-sulfonic acid
-
mixed inhibition at 37°C
0.052
(1R,4S)-4-amino-2-cyclopentene-1-carboxylic acid
-
-
1.3
(1R,4S)-4-amino-3-fluorocyclopent-2-enecarboxylic acid
-
in potassium diphosphate buffer (pH 8.5)
2.8
(1R,4S)-4-amino-3-pentafluoroethylcyclopent-2-enecarboxylic acid
-
in potassium diphosphate buffer (pH 8.5)
4.2
(1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluoromethylethylidene)-cyclopentanecarboxylic acid
-
in potassium diphosphate buffer (pH 8.5)
2.7
(1S,4R)-4-amino-2-cyclopentene-1-carboxylic acid
-
-
3.75
(1S,4S)-2-(difluoromethylidene)-4-(1H-tetrazol-5-yl)cyclopentanamine
-
pH 6.5
1.2
(4R)-4-amino-1-cyclopentene-1-carboxylic acid
-
-
72
(4S)-4-amino-1-cyclopentene-1-carboxylic acid
-
-
5.6
1H-tetrazole-5-(alpha-vinyl-propanamine)
-
pH 8.5
0.008 - 0.013
2,4-diaminobutanoate
0.434
2-Aminobenzenesulfonate
-
competitive inhibition at 37°C
0.033
2-aminobutanoate
Candida guilliermondii var. membranaefaciens
-
-
1.01
2-aminoethane phosphonic acid
-
competitive inhibition at 37°C
0.598
2-N-(acetylamino)cyclohexane sulfonic acid
-
competitive inhibition at 37°C
0.00018
2-oxoglutarate
-
38°C, pH 8.5
0.013
3-Mercaptopropionic acid
-
-
1.59
4-(aminomethyl)-1H-pyrrole-2-carboxylic acid
-
pH 8.5, 25°C
1.64
4-(aminomethyl)furan-2-carboxylic acid
-
pH 8.5, 25°C
2.27
4-(aminomethyl)furan-3-carboxylic acid
-
pH 8.5, 25°C
1.35
4-(aminomethyl)thiophene-2-carboxylic acid
-
pH 8.5, 25°C
2.86
4-(aminomethyl)thiophene-3-carboxylic acid
-
pH 8.5, 25°C
0.47
4-acryloylphenol
-
-
0.44
4-amino-2-fluorobutanoate
-
pH 8.6, 37°C
2.6 - 26
4-aminohex-5-enoic acid
2.14
5-(aminomethyl)-1H-pyrrole-2-carboxylic acid
-
pH 8.5, 25°C
1.4
5-(aminomethyl)furan-2-carboxylic acid
-
pH 8.5, 25°C
2.49
5-(aminomethyl)thiophene-2-carboxylic acid
-
pH 8.5, 25°C
0.039
alpha-alanine
Candida guilliermondii var. membranaefaciens
-
-
0.24 - 1.13
Aminooxyacetate
3.7
ATP
-
-
0.0355 - 0.55
beta-Alanine
0.002
Butyric acid
Candida guilliermondii var. membranaefaciens
-
-
0.6
DL-3-amino-1-cyclopentene-1-carboxylic acid
-
-
38
DL-trans-4-amino-2-cyclopentene-1-carboxylic acid
-
-
0.0044
ethanolamine O-sulfate
-
37°C, pH 8.4
68
ethylamine-2-sulfonic acid
-
pH 8.6, 25°C
19 - 233
Glutarate
3.9 - 780
Maleate
0.003
propionic acid
Candida guilliermondii var. membranaefaciens
-
-
27 - 720
succinate
0.0066
Succinic semialdehyde
-
38°C, pH 8.5
5.6
tetrazole-5-(alpha-vinyl-propanamine)
-
-
0.32 - 2.6
vigabatrin
additional information
additional information
inihbition kinetics
-