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2.6.1.21: D-amino-acid transaminase

This is an abbreviated version!
For detailed information about D-amino-acid transaminase, go to the full flat file.

Word Map on EC 2.6.1.21

Reaction

D-alanine
+
2-oxoglutarate
=
pyruvate
 +
D-glutamate

Synonyms

aminotransferase, D-alanine, AspFum, AspOry, AspTer, AtDAT1, D-AA transaminase, D-AAT, D-alanine aminotransferase, D-alanine transaminase, D-alanine:2-oxoglutarate aminotransferase, D-amino acid aminotransferase, D-amino acid transaminase, D-aspartate transaminase, D-aspartic aminotransferase, DAA aminotransferase, DAA transaminase, DAAT, DAT, DatA, Dret, Dret_1107, EC 2.6.1.10, FQP89_01185, GibZea, MSMEG_5795, MycVan, NeoFis, PenChr, TRA-01185

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.21 D-amino-acid transaminase

Inhibitors

Inhibitors on EC 2.6.1.21 - D-amino-acid transaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Amino-3-butenoate
3-Methyl-2-benzothiazolone hydrazone hydrochloride
-
-
aminooxyacetic acid
-
0.0001 mM, 50% inhibition
Aminoxyacetate
-
0.01 mM, 90% inhibition
beta-Chloro-D-alanine
CaCl2
-
45 mM, 50% inhibition
cysteine
-
inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate
D-2-aminobutanoate
-
inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
D-asparagine
-
inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak
D-Aspartate
-
inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
D-cycloserine
D-cysteine
-
0.1 mM, 60% inhibition
D-glutamate
-
competitive to D-alanine, noncompetitive to 2-oxoglutarate
D-methionine
-
inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
D-oxamycin
-
0.000025 mM, 50% inhibition
D-penicillamine
-
1 mM, 73% inhibition
D-serine
-
inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate
DL-alpha-Methylserine
-
inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak
HgCl2
-
0.1 mM, complete inhibition
hydroxylamine
KCl
-
80 mM, 50% inhibition
L-cysteine
-
2 mM, 49% inhibition
L-oxamycin
-
0.001 mM, 50% inhibition
L-Penicillamine
-
1 mM, 28% inhibition
L-serine
-
10 mM, 22% inhibition
Maleate
-
12 mM, 30% inhibition at pH 7.1, no inhibition at pH 8.3
N-ethylmaleimide
-
1 mM, 50% inhibition
Na2SO4
-
40 mM, 50% inhibition
NaCl
-
75 mM, 50% inhibition
NH4Cl
-
80 mM, 50% inhibition
oxamycin
-
D-isomer by a factor of 40 more inhibitory than L-isomer
p-chloromercuribenzoate
-
4 mM, 36% inhibition, D-alanine and pyridoxal 5'-phosphate protect to some extent
phenylhydrazine
succinate
-
12 mM, 18% inhibition at pH 7.1, no inhibition at pH 8.3
Tris-HCl
-
100 mM, 50% inhibition
additional information
-