2.6.1.28: tryptophan-phenylpyruvate transaminase
This is an abbreviated version!
For detailed information about tryptophan-phenylpyruvate transaminase, go to the full flat file.
Reaction
Synonyms
aminotransferase, tryptophan-phenylpyruvate, L-tryptophan-alpha-ketoisocaproate aminotransferase, TdiD
ECTree
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Substrates Products
Substrates Products on EC 2.6.1.28 - tryptophan-phenylpyruvate transaminase
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REACTION DIAGRAM
L-2-aminobutanoate + phenylpyruvate
L-phenylalanine + 2-oxobutanoate
-
-
-
-
?
L-isoleucine + phenylpyruvate
L-phenylalanine + 3-methyl-2-oxopentanoate
-
-
-
-
?
L-phenylalanine + 2-oxobutanoate
phenylpyruvate + 2-aminobutanoate
-
low activity
-
-
r
L-phenylalanine + 2-oxoisohexanoate
phenylpyruvate + L-leucine
-
i.e alpha-ketoisocaproate, highest activity as amino acceptor
-
-
r
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
2% of the activity with alpha-ketoisocaproate
-
-
r
L-tryptophan + 2-oxobutanoate
3-indole-2-oxopropanoate + 2-aminobutanoate
-
weak activity
-
-
r
L-tryptophan + 2-oxohexanoate
3-indole-2-oxopropanoate + L-norleucine
-
-
-
-
r
L-tryptophan + 2-oxoisohexanoate
3-indole-2-oxopropanoate + L-leucine
-
-
-
-
r
L-tryptophan + 2-oxopentanoate
3-indole-2-oxopropanoate + norvaline
-
-
-
-
r
L-tryptophan + 4-hydroxyphenylpyruvate
3-indole-2-oxopropanoate + ?
15% of the activity with phenylpyruvate
-
-
?
L-tryptophan + p-hydroxyphenylpyruvate
3-indole-2-oxopropanoate + tyrosine
-
-
-
-
r
L-tryptophan + pyruvate
3-indole-2-oxopropanoate + L-alanine
-
2% of the activity with alpha-ketoisocaproate
-
-
r
phenylpyruvate + DL-5-hydroxytryptophan
phenylalanine + 3-(5-hydroxyindole)-2-oxopropanoate
-
-
-
-
r
phenylpyruvate + DL-histidine
phenylalanine + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
low activity
-
-
r
phenylpyruvate + L-citrulline
phenylalanine + 2-oxo-5-ureido-pentanoate
-
low activity
-
-
r
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
no activity
-
-
?
3-indole-2-oxopropanoate + L-valine
-
i.e. L-Trp + dimethylpyruvate
-
-
r
L-tryptophan + 2-oxoisopentanoate
3-indole-2-oxopropanoate + L-valine
-
i.e. L-Trp + dimethylpyruvate
-
-
r
3-indole-2-oxopropanoate + L-phenylalanine
-
phenylpyruvate is the most effective amino acceptor, in the reverse reaction phenylalanine is the most effective amino donor
i.e. indolepyruvate + L-Phe
r
L-tryptophan + phenylpyruvate
3-indole-2-oxopropanoate + L-phenylalanine
-
conversion of tryptophan into the plant indolylacetic acid
-
-
?
L-tryptophan + phenylpyruvate
3-indole-2-oxopropanoate + L-phenylalanine
-
-
-
?
L-tryptophan + phenylpyruvate
3-indole-2-oxopropanoate + L-phenylalanine
pyruvate, 2-oxoglutarate, and 2-oxo-(4-methylthio)butyrateare no co-substrates
for biosynthesis of terrequinone A, 3-indole-2-oxopropanoate is used for an unusual nonoxidative coupling by the tridomain nonribosomal peptide synthetase TdiA
-
?
L-tryptophan + phenylpyruvate
3-indole-2-oxopropanoate + L-phenylalanine
-
-
i.e. indolepyruvate + L-Phe
r
phenylalanine + 3-methyl-2-oxopentanoate
-
-
-
-
r
phenylpyruvate + DL-isoleucine
phenylalanine + 3-methyl-2-oxopentanoate
-
-
-
-
r
phenylalanine + 4-methyl-2-oxopentanoate
-
-
-
-
r
phenylpyruvate + DL-leucine
phenylalanine + 4-methyl-2-oxopentanoate
-
-
-
-
r
phenylalanine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
-
r
phenylpyruvate + DL-methionine
phenylalanine + 4-methylsulfanyl-2-oxobutanoate
-
low activity
-
-
r
phenylalanine + 3-methyl-2-oxobutanoate
-
-
-
-
r
phenylalanine + 3-(4-hydroxyphenyl)-2-oxopropanoate
-
-
-
-
r
phenylpyruvate + L-tyrosine
phenylalanine + 3-(4-hydroxyphenyl)-2-oxopropanoate
-
-
-
-
r
?
-
-
glutamic acid, aspartic acid, alanine, threonine, arginine, glutamine and serine are practically inactive
-
-
?
additional information
?
-
catalyzes the first enzymatic step specific to the metabolic pathway toward terrequinone A
-
-
?
additional information
?
-
no amino acceptor substrate: pyruvic acid, 2-oxoglutaric acid, 2-oxo-butyric acid, 2-oxo-valeric acid
-
-
?
additional information
?
-
-
no activity with glutamate, 2-oxoglutarate
-
-
?