2.6.1.39: 2-aminoadipate transaminase
This is an abbreviated version!
For detailed information about 2-aminoadipate transaminase, go to the full flat file.
Word Map on EC 2.6.1.39
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2.6.1.39
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5'-phosphate
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thermus
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saccharopine
-
aminotransferases
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thermophilus
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transamination
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dicarboxylic
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semialdehyde
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kynurenic
-
l-kynurenine
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2-oxoadipate
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l-lysine
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pharmacology
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medicine
- 2.6.1.39
- 5'-phosphate
-
thermus
- saccharopine
- aminotransferases
- thermophilus
-
transamination
-
dicarboxylic
- semialdehyde
-
kynurenic
- l-kynurenine
- 2-oxoadipate
- l-lysine
- pharmacology
- medicine
Reaction
Synonyms
2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, AAA-AT, AadAT, AAT, alpha-aminoadipate aminotransferase, alpha-aminoadipate aminotransferase (gene aro8), aminoadipate aminotransferase, aminoadipate aminotransferase/kynurenine aminotransferase II, Aro8, GKAT, glutamate-alpha-ketoadipate transaminase, glutamic-ketoadipic transaminase, halogenated tyrosine aminotransferase, KAT II/AADAT, kynurenine aminotransferase II, kynurenine aminotransferase II (EC 2.6.1.7), kynurenine/alpha-aminoadipate aminotransferase, More
ECTree
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Substrates Products
Substrates Products on EC 2.6.1.39 - 2-aminoadipate transaminase
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REACTION DIAGRAM
2-oxo-3-methylvalerate + L-glutamate
2-amino-3-methylpentanoate + 2-oxoglutarate
-
-
-
-
?
2-oxoglutarate + L-2-aminoadipate
2-oxoadipate + L-glutamate
-
-
-
-
r
2-oxoglutarate + L-tyrosine
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
-
r
L-2-aminoadipate + 4-hydroxyphenylpyruvate
2-oxoadipate + L-tyrosine
-
-
-
-
?
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
phenylpyruvate + 2-aminoadipate
L-phenylalanine + 2-oxoglutarate
-
-
-
-
?
L-2-aminoadipate + 2-oxoglutarate
-
-
-
r
2-oxoadipate + L-glutamate
L-2-aminoadipate + 2-oxoglutarate
-
-
-
-
?
3,5-diiodophenylpyruvate + L-glutamate
-
-
-
-
r
3,5-di-iodotyrosine + 2-oxoglutarate
3,5-diiodophenylpyruvate + L-glutamate
-
-
-
-
r
DL-2-aminopimelic acid + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
lysine catabolic pathway
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
lysine catabolic pathway
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
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lysine and tryptophan metabolism
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
also transamination of methionine, 2-oxocaproic acid, phenylpyruvate and 2-oxo-4-methylthiobutyrate
-
-
?
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
lysine catabolic pathway
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
lysine catabolic pathway
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
r
L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
?
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
r
L-histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
r
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
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-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
-
-
-
-
r
?
-
-
only slight activity with phenylalanine, tryptophan, tyrosine, aspartate or alanine as amino group donors, glyoxylate is no amino group acceptor
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-
?
additional information
?
-
enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57
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-
?
additional information
?
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-
2 isoenzymes, AadAT-I and AadAT-II, isoenzyme AadAT-II shows additional activity with tryptophan or kynurenine-2-oxoglutarate reaction, only slight activity with asparagine, alanine, arginine, ornithine, isoleucine, valine, leucine, lysine, serine, threonine, phenylalanine, tyrosine, histidine, glutamine, methionine or aspartate with 2-oxoglutarate
-
-
?
additional information
?
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-
only slight activity with phenylalanine, tryptophan, tyrosine, aspartate or alanine as amino group donors, glyoxylate is no amino group acceptor
-
-
?
additional information
?
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-
less than 2% activity with L-aspartate, L-alanine, L-alpha-aminobutyrate, glycine, L-valine, L-leucine, L-isoleucine, L-norvaline, L-epsilon-aminocaproate, L-threonine, L-serine, L-homoserine, L-cysteine, L-methionine, L-lysine, L-arginine, L-citrulline, L-ornithine, L-histidine, L-tyrosine, L-tryptophan, L-phenylalanine, L-proline and L-glutamate
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-
?
additional information
?
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-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
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-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
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-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
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-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
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-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
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-
KAT and AadAT activities are associated with 2 different proteins
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-
?
additional information
?
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-
KAT and AadAT activities are associated with 2 different proteins
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-
?
additional information
?
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-
only slight activity with phenylalanine, tryptophan, tyrosine, aspartate or alanine as amino group donors, glyoxylate is no amino group acceptor
-
-
?
additional information
?
-
-
2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein
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-
?
additional information
?
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-
AAA-AT can recognize various kinds of substrates using the mobile alpha2 helix
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-
?
additional information
?
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negligible activity is observed for L-Asp
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-
?
additional information
?
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-
negligible activity is observed for L-Asp
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-
?