2.6.1.42: branched-chain-amino-acid transaminase

This is an abbreviated version!
For detailed information about branched-chain-amino-acid transaminase, go to the full flat file.

Reaction

Synonyms

(R)-selective omega-aminotransferase, AGT, alpha-KGA, At1g50110, At5g17310, Bat1, Bat1p, BAT2, Bat2p, BCAA, BCAA aminotransferase, BCAA-AT, BCAATase, BcaT, BCAT-1, BCAT1, Bcat2, BCAT4, Bcat6, BCAT7, BCATc, BCATm, branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1, branched chain aminotransferase, branched chain aminotransferase IlvE, branched chain aminotransferase, cytosolic isoform, branched chain aminotransferase, mitochondrial isoform, branched-chain amino acid aminotransferase, branched-chain amino acid aminotransferase 1, branched-chain amino acid aminotransferase 2, branched-chain amino acid aminotransferase 3, branched-chain amino acid aminotransferase 4, branched-chain amino acid aminotransferase 5, branched-chain amino acid aminotransferase 6, branched-chain amino acid transaminase, branched-chain amino acid transaminase 1, branched-chain amino acid transferase, branched-chain amino acid-glutamate transaminase, branched-chain amino-acid aminotransferase, branched-chain amino-acid transaminase, branched-chain aminotransferase, branched-chain aminotransferase 7, branched-chain aminotransferase4, CsBCAT2, CsBCAT3, CsBCAT7, eBCAT, EC 2.6.1.6, glutamate-branched-chain amino acid transaminase, hBCAT, hBCATm, Hoch3033, IlvE, IlvE aminotransferase, ilvE1, L-branched chain amino acid aminotransferase, L-leucine-alpha-ketoglutarate transaminase, leucine aminotransferase, leucine transaminase, Mevan_0408, mitochondrial branched chain aminotransferase, More, MtIlvE, PsBCAT, R-omegaAT, R-omegaAT_Bcel, R-omegaAT_Bthu, Rv2210c, SlBCAT1, SlBCAT2, SlBCAT3, SlBCAT4, SlBCAT5, SlBCAT6, SpBCAT1, TA-B, transaminase B, trd_1610, Tter_1720, TUZN1299, VMUT0738, VMUT_0738

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.42 branched-chain-amino-acid transaminase

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Results	in table
14	Activating Compound
49815	AA Sequence
19	Application
1	CAS Registry Number
73	Cloned(Commentary)
80	Cofactor
24	Crystallization (Commentary)
661	Disease/ Diagnostics
2	Expression
212	General Information
9	General Stability
24	IC50 Value
188	Inhibitors
129	kcat/KM [mM/s]
18	Ki Value [mM]
335	KM Value [mM]
111	Localization
3	Metals/Ions
77	Molecular Weight [Da]
213	Natural Substrates/ Products (Substrates)
526	Organism
3	Oxidation Stability
38	Pathway
222	PDB ID
60	pH Optimum
9	pH Range
7	pH Stability
3	pI Value
5	Posttranslational Modification
40	Protein Variants
75	Purification (Commentary)
42	Reaction
1	Reaction Type
214	Reference
190	Source Tissue
165	Specific Activity [micromol/min/mg]
13	Storage Stability
1082	Substrates and Products (Substrate)
102	Subunits
447	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
4	Temperature Range [°C]
11	Temperature Stability [°C]
172	Turnover Number [1/s]

Oxidation Stability

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Oxidation Stability on EC 2.6.1.42 - branched-chain-amino-acid transaminase

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OXIDATION STABILITY

ORGANISM

UNIPROT

LITERATURE

BCATm is more susceptible to ROS, whereas modification of BCATc by RNS results in S-nitrosylation and S-glutathionylation

Homo sapiens

O15382, P54687

758657

the activity of oxidized BCAT with 0.5 mM hydrogen peroxide for 2 h at 25°C shows 99.5% inhibition

Homo sapiens

O15382

674728

the enzyme activity in the presence of 15% v/v organic solvents showes significant tolerance of VMUT0738 to solvents

Vulcanisaeta moutnovskia

F0QW25

759134