2.6.1.44: alanine-glyoxylate transaminase
This is an abbreviated version!
For detailed information about alanine-glyoxylate transaminase, go to the full flat file.
Word Map on EC 2.6.1.44
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2.6.1.44
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hyperoxaluria
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peroxisomal
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end-stage
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oxalosis
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nephrocalcinosis
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transamination
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dimethylarginine
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stone
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urolithiasis
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mistargeting
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pyridoxine
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nephrolithiasis
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medicine
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liver-kidney
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hydroxypyruvate
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grhpr
-
analysis
-
diagnostics
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nutrition
- 2.6.1.44
- hyperoxaluria
- peroxisomal
-
end-stage
- oxalosis
- nephrocalcinosis
-
transamination
- dimethylarginine
- stone
- urolithiasis
-
mistargeting
- pyridoxine
- nephrolithiasis
- medicine
-
liver-kidney
- hydroxypyruvate
- grhpr
- analysis
- diagnostics
- nutrition
Reaction
Synonyms
3-hydroxykynurenine transaminase, 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase, AGT, AGT-Ma, AGT-Mi, AGT1, AGT2, AGX, AGXT, AGXT2, alanine aminotransferase, alanine glyoxalate transaminase 2, alanine glyoxylate aminotransferase, alanine-glyoxalate aminotransferase, alanine-glyoxalate transaminase 1, alanine-glyoxylate aminotransferase, alanine-glyoxylate aminotransferase 2, alanine-glyoxylate aminotransferase isoenzyme 2, alanine-glyoxylate aminotransferase-2, alanine-glyoxylic aminotransferase, alanine: glyoxylate aminotransferase, alanine:2-oxoglutarate aminotransferase, alanine:glyoxylate aminotransferase, alanine:glyoxylate aminotransferase 1, alanine:glyoxylate aminotransferase 2, alanine:glyoxylate aminotransferase type 1, alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase, aminotransferase 3, AT3, At3g08860, cytosolic alanine aminotransferase, D-AIB AT, EC 2.6.1.51, GGT, glyoxylate aminotransferase AGT1, L-alanine-glycine transaminase, L-alanine-glyoxylate aminotransferase, L-alanine:glyoxylate aminotransferase, More, serine pyruvate aminotransferase, serine:pyruvate/alanine:glyoxylate aminotransferase, SPT/AGT
ECTree
2.6.1.44 alanine-glyoxylate transaminaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.6.1.44 - alanine-glyoxylate transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
?
L-alanine + 4-methylthio-2-oxobutyrate
pyruvate + L-methionine
-
poor amino acceptor
-
-
ir
L-histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
ir
L-isoleucine + glyoxylate
3-methyl-2-oxopropanoate + glycine
-
isoenzyme 1
-
-
ir
L-tyrosine + pyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
-
-
ir
Nomega,Nomega-dimethyl-L-arginine + pyruvate
5-(N,N-dimethylcarbamidamido)-2-oxopentanoate + alanine
-
-
-
?
L-2-aminobutyrate + glyoxylate
2-oxobutanoate + glycine
-
-
-
ir
L-alanine + glyoxylate
glycine + pyruvate
transamination half-reaction kinetic parameters
-
-
r
L-alanine + glyoxylate
pyruvate + glycine
photorespiratory enzyme
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ir
L-alanine + glyoxylate
pyruvate + glycine
-
-
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
-
key role in the transamination/detoxification of glyoxylate
-
ir
L-alanine + glyoxylate
pyruvate + glycine
-
key role in the transamination/detoxification of glyoxylate
-
ir
L-alanine + glyoxylate
pyruvate + glycine
the enzyme is highly specific for catalysing glyoxylate to glycine processing, thereby playing a key role in glyoxylate detoxification
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
the enzyme is highly specific for catalysing glyoxylate to glycine processing
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
high substrate specificity for Ala and glyoxylate
-
-
ir
L-alanine + glyoxylate
pyruvate + glycine
Hydrogenobacter thermophilus TK-6 / IAM 12695
high substrate specificity for Ala and glyoxylate
-
-
ir
L-alanine + glyoxylate
pyruvate + glycine
-
isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors
-
ir
L-alanine + glyoxylate
pyruvate + glycine
-
isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors
-
ir
L-alanine + glyoxylate
pyruvate + glycine
-
regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates
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ir
L-alanine + phenylpyruvate
pyruvate + L-phenylalanine
-
isoenzyme 1, less effectively acceptor
-
-
ir
L-alanine + phenylpyruvate
pyruvate + L-phenylalanine
-
isoenzyme 1, less effectively acceptor
-
-
ir
L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
-
-
-
ir
L-asparagine + glyoxylate
4-amino-2,4-dioxobutanoate + glycine
-
isoenzyme 1
-
-
ir
L-asparagine + glyoxylate
4-amino-2,4-dioxobutanoate + glycine
-
isoenzyme 1
-
-
ir
L-cysteine + pyruvate
3-mercapto-2-oxopropanoate + L-alanine
-
-
-
ir
L-cysteine + pyruvate
3-mercapto-2-oxopropanoate + L-alanine
-
enzyme catalyzes both beta-elimination and half-transamination of L-cysteine together with pyruvate transamination via a ketimine common intermediate. L-cysteine partitions between the two reactions with a ratio of 2.5
-
?
L-histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
-
ir
L-histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
ir
L-histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
isoenzyme 1
-
-
ir
L-histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
isoenzyme 1
-
-
ir
L-leucine + glyoxylate
4-methyl-2-oxopentanoate + glycine
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isoenzyme 1
-
-
ir
L-methionine + glyoxylate
4-methylsulfanyl-2-oxobutanoate + glycine
-
-
-
ir
L-methionine + glyoxylate
4-methylsulfanyl-2-oxobutanoate + glycine
-
isoenzyme 1
-
-
ir
L-methionine + glyoxylate
4-methylsulfanyl-2-oxobutanoate + glycine
-
isoenzyme 1
-
-
ir
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
ir
L-phenylalanine + glyoxylate
phenylpyruvate + glycine
-
-
-
ir
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
ir
L-serine + glyoxylate
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
3-hydroxy-2-oxopropanoate + glycine
-
-
-
ir
L-serine + glyoxylate
3-hydroxy-2-oxopropanoate + glycine
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isoenzyme 1
-
-
ir
L-serine + pyruvate
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
3-hydroxy-2-oxopropanoate + L-alanine
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isoenzyme 1
-
-
ir
L-serine + pyruvate
3-hydroxy-2-oxopropanoate + L-alanine
-
-
-
ir
L-serine + pyruvate
3-hydroxy-2-oxopropanoate + L-alanine
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isoenzyme 1
-
-
ir
L-tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
-
-
-
ir
L-tryptophan + pyruvate
3-indole-2-oxopropanoate + L-alanine
-
-
-
ir
L-tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
ir
L-tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
isoenzyme 1
-
-
ir
L-tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
isoenzyme 1
-
-
ir
additional information
?
-
-
aminoadipate, asparagine, aspartate, glutamate, isoleucine, lysine, threonine and valine are no substrates
-
-
?
additional information
?
-
enzymatic activity is not detected using beta-alanine as the amino donor with either pyruvate or glyoxylate as amino acceptors
-
-
-
additional information
?
-
-
enzymatic activity is not detected using beta-alanine as the amino donor with either pyruvate or glyoxylate as amino acceptors
-
-
-
additional information
?
-
Arabidopsis thaliana Col7
enzymatic activity is not detected using beta-alanine as the amino donor with either pyruvate or glyoxylate as amino acceptors
-
-
-
additional information
?
-
-
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
-
-
?
additional information
?
-
aminoadipate, asparagine, aspartate, glutamate, isoleucine, lysine, threonine and valine are no substrates
-
-
?
additional information
?
-
-
aminoadipate, asparagine, aspartate, glutamate, isoleucine, lysine, threonine and valine are no substrates
-
-
?
additional information
?
-
-
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
-
-
?
additional information
?
-
-
enzyme is highly specific for catalyzing glyoxylate to glycine processing, playing a key role in glyoxylate detoxification
-
-
?
additional information
?
-
enzyme is highly specific for catalyzing glyoxylate to glycine processing, playing a key role in glyoxylate detoxification
-
-
?
additional information
?
-
alanine:glyoxylate aminotransferase is able to catalyze the alpha,beta-elimination of beta-chloro-L-alanine with a catalytic efficiency similar to that of the physiological transaminase reaction with L-alanine. The enzyme catalyzes both the alpha,beta-elimination and half-transamination of the natural amino acid L-cysteine together with pyruvate half-transamination
-
-
?
additional information
?
-
enzyme is able to catalyze the alpha,beta-elimination of beta-chloro-L-alanine with a kcat value of 0.74 per s and a Km value of 0.51 mM
-
-
?
additional information
?
-
-
mitochondrially localized human AGXT2 is able to effectively metabolize asymmetric dimethylarginine in vivo
-
-
?
additional information
?
-
the enzyme is also active as serine-pyruvate aminotransferase, EC 2.6.1.51
-
-
-
additional information
?
-
-
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
-
-
?
additional information
?
-
-
isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan
-
-
?
additional information
?
-
-
2-oxoglutarate is not an amino acceptor, little or no activity with asparagine, glutamine, glutamate, threonine, cysteine, methionine, arginine, leucine, valine, isoleucine, phenylalanine, tryptophan, histidine or tyrosine as amino donors
-
-
?
additional information
?
-
-
utilizes only glyoxylate as amino acceptor, hydroxypyruvate, 2-oxoglutarate, phenylpyruvate and 2-oxo-4-methyl-thiobutyrate are inactive, only L-alanine as amino donor, L-serine, L-threonine, L-glutamic acid, L-glutamine, L-aspartic acid, L-asparagine, L-ornithine, L-leucine, L-valine, L-isoleucine, L-histidine, L-phenylalanine, L-tryptophan and L-tyrosine are no substrates
-
-
?
additional information
?
-
-
strict specificity for L-alanine and glyoxylate as substrates
-
-
?
