2.6.1.49: dihydroxyphenylalanine transaminase

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For detailed information about dihydroxyphenylalanine transaminase, go to the full flat file.

Reaction

Synonyms

aminotransferase, dihydroxyphenylalanine, aspartate-DOPP transaminase, ADT, dihydroxyphenylalanine aminotransferase, dopa aminotransferase, dopa transaminase, glutamate-DOPP transaminase, GDT, L-dopa transaminase, phenylalanine-DOPP transaminase, PDT

ECTree

2 Transferases

2.6 Transferring nitrogenous groups

2.6.1 Transaminases

2.6.1.49 dihydroxyphenylalanine transaminase

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Results	in table
1	Activating Compound
3	AA Sequence
1	CAS Registry Number
1	General Stability
15	Inhibitors
2	KM Value [mM]
8	Organism
6	Pathway
6	pH Optimum
1	pH Range
3	pH Stability
1	Purification (Commentary)
1	Reaction
1	Reaction Type
8	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 2.6.1.49 - dihydroxyphenylalanine transaminase

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3-hydroxy-4-benzyloxyamine dihydrogen phosphate

Al3+

strong inhibition

carbidopa

Co2+

weak inhibition

Cu2+

strong inhibition

Fe2+

strong inhibition

iodoacetic acid

1 mM, 75% inhibition

KCN

1 mM, 93% inhibition, pyridoxal 5'-phosphate protects

636682

Ni2+

Alcaligenes faecalis

inhibition of ADT and GDT, not PDT

636685

p-chloromercuriphenyl sulfonic acid

Cavia porcellus

0.02 mM, 92% inhibition, addition of 1 mM glutathione protects to 100%

636682

Zn2+

Alcaligenes faecalis

weak inhibition

636685

additional information

2 entries