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2.6.1.52: phosphoserine transaminase

This is an abbreviated version!
For detailed information about phosphoserine transaminase, go to the full flat file.

Reaction

4-phosphooxy-L-threonine
+
2-oxoglutarate
=
(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate
 +
L-glutamate

Synonyms

3-O-phospho-L-serine:2-oxoglutarate aminotransferase, 3-phosphoserine aminotransferase, AspAT, AtPSAT, AtPSAT1, BCIR PSAT, bmPSAT, EhPSAT, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, phosphoserine aminotransferase, phosphoserine aminotransferase 1, phosphoserine aminotransferase1, phosphoserine aminotransferase2, phosphoserine aminotransferases, PSAT, PSAT alpha, PSAT beta, PSAT-BALC, PSAT-BCIRA, PSAT-ECOLI, PSAT1, PSAT2, PSerAT, serC, sll1559

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.52 phosphoserine transaminase

Inhibitors

Inhibitors on EC 2.6.1.52 - phosphoserine transaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Amino-4-phosphonobutyrate
-
-
2-oxoglutarate
-
-
Aminooxyacetate
AOA, the transaminase inhibitor represses cell growth in a TAZ/YAP-dependent manner
chloride
the chloride ion in EhPSAT becomes trapped in the space between residues Gly99, Val 100, Ile 149, Thr 148, and Asn 147. The halide-binding site in close proximity to the active site is detected. A stretch of six amino acids (146-NNTIYG-151) only conserved in the Entamoeba genus, contributes to halide binding. Structure comparisons, overview
L-cysteine
L-glutamate
-
-
L-phosphoserine
-
product inhibition
O-acetylserine
10 mM, 50% inhibition
o-phospho-D-serine
10 mM, 70% inhibition
O-phospho-L-threonine
10 mM, 65% inhibition
additional information
-
not inhibitory: chloride, fluoride and bromide up to 200 mM
-