2.6.1.57: aromatic-amino-acid transaminase
This is an abbreviated version!
For detailed information about aromatic-amino-acid transaminase, go to the full flat file.
Word Map on EC 2.6.1.57
-
2.6.1.57
-
aminotransferases
-
transamination
-
phenylpyruvate
-
arats
-
l-phenylalanine
-
l-tyrosine
-
prephenate
-
indole-3-pyruvic
-
4-hydroxyphenylpyruvate
-
histidinol
-
l-arogenate
-
5'-phosphate-dependent
-
indolepyruvate
-
2-phenylethanol
-
synthesis
- 2.6.1.57
- aminotransferases
-
transamination
- phenylpyruvate
-
arats
- l-phenylalanine
- l-tyrosine
- prephenate
-
indole-3-pyruvic
- 4-hydroxyphenylpyruvate
- histidinol
- l-arogenate
-
5'-phosphate-dependent
- indolepyruvate
- 2-phenylethanol
- synthesis
Reaction
Synonyms
AAT, AAT I-III, AAT1, aminotransferase, aromatic amino acid, ArAT, ArAT-I, ArAT-ITL, ArATPf, ArATPh, Aro8, ARO9, AroAT, AroAT II, AroATEs, AroH, arom. amino acid transferase, arom.-amino-acid transaminase, aromatic amino acid aminotransferase, aromatic amino acid transaminase, aromatic amino transferase I, aromatic aminotransferase, aromatic aminotransferase AT-1, aromatic aminotransferase AT-2, aromatic aminotransferase II, aromatic L-amino acid transaminase, aromatic-amino-acid aminotransferase, aromatic-amino-acid:2-oxoglutarate transaminase, AT-1, AT-2, AT-IA, At1g80360, bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase, CaAro8p, CaAro9p, CaYer152Cp, eAroATEs, F5I6.11, hisC1, indole severe sensitive 1, ISS1, More, pdArAT, pdAroAT, PH1371, phhC, PjAT, SmAroAT, TyrB, TyrB-2, VAT1, Yer152, Yer152C
ECTree
2.6.1.57 aromatic-amino-acid transaminaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.6.1.57 - aromatic-amino-acid transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4-dioxo-4-phenylbutyric acid + L-Asp
(2S)-2-amino-4-oxo-4-phenylbutyric acid + oxaloacetate
2-amino-3-phenylpropanol + 2-oxoglutarate
2-oxo-3-phenylpropanol + L-glutamate
-
aromatic aminotransferase from strain CB 6
-
?
2-oxo-4-phenylbut-3-enoic acid + L-Asp
(3E,2S)-2-amino-4-phenylbutenoic acid + oxaloacetate
2-oxoadipate + L-glutamate
alpha-aminoadipate + 2-oxoglutarate
-
-
-
r
2-oxoglutarate + L-histidine
L-glutamate + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
-
-
r
3-iodo-L-tyrosine + 2-oxoglutarate
3-(3-iodophenyl)-2-oxopropanoate + L-glutamate
-
-
-
?
3-iodo-L-tyrosine + oxaloacetate
3-(3-iodophenyl)-2-oxopropanoate + L-aspartate
-
-
-
?
5-hydroxytryptophan + 2-oxoglutarate
3-(5-hydroxyindole)-2-oxopropanoate + L-glutamate
-
19.5% of the activity with phenylalanine
-
?
aspartate + 3-phenylpyruvate
oxaloacetate + L-phenylalanine
-
-
r
L-5-fluorotryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-5-methyltryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-arogenate + indolepyruvate
L-tryptophan + 3-(1-carboxy-4-hydroxycyclohexa-2,5-dienyl)2-oxopropanoate
-
-
-
?
L-aspartate + 3-(4-hydroxyphenyl)pyruvate
L-tyrosine + oxaloacetate
-
-
r
L-glutamine + indole pyruvate
2-oxoglutamine + L-tryptophan
-
AAT I and II
-
?
L-histidine + alpha-ketomethiobutyrate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-methionine
-
-
-
?
L-histidine + indole pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-tryptophan
-
-
-
?
L-isoleucine + alpha-ketomethiobutyrate
3-methyl-2-oxo-pentanoate + L-methionine
-
-
-
?
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
-
reaction of EC 2.6.1.7
-
-
r
L-leucine + indole pyruvate
4-methyl-2-oxopentanoate + L-tryptophan
-
-
-
?
L-lysine + alpha-ketomethiobutyrate
2-oxo-6-amino-hexanoate + L-methionine
-
-
-
?
L-methionine + indole pyruvate
4-methylsulfanyl-2-oxobutanoate + L-tryptophan
-
AAT I and II
-
?
L-phenylalanine + 2-oxoadipate
phenylpyruvate + L-2-aminoadipate
-
-
-
r
L-phenylalanine methylester + 2-oxoglutarate
2-oxo-3-phenylpropanoate methylester + L-glutamate
-
aromatic aminotransferase from strain CB 6
-
?
L-tryptophan + indole pyruvate
3-indole-2-oxopropanoate + L-tryptophan
-
-
-
?
L-tryptophan + phenylpyruvate
3-indole-2-oxopropanoate + L-phenylalanine
-
-
-
?
L-tyrosine + indole pyruvate
4-hydroxyphenylpyruvate + L-tryptophan
-
-
-
?
L-valine + alpha-ketomethiobutyrate
3-methyl-2-oxo-butanoate + L-methionine
-
-
-
?
oxaloaspartate + Ile
L-Asp + 3-methyl-2-oxo-pentanoate
at 2.5 mM, 7.1% of the amine donor activity of Phe
-
-
?
oxoglutarate + Ile
L-Asp + 3-methyl-2-oxo-pentanoate
Ile, at 2.5 mM, 14.9% of the amine donor activity of Phe
-
-
?
p-aminophenylalanine + 2-oxoglutarate
p-aminophenylpyruvate + L-glutamate
-
aromatic aminotransferase from strain CB 60 and CB 6
-
?
p-aminophenylserine + 2-oxoglutarate
3-hydroxy-2-oxo-3-(p-aminophenyl)propanoic acid + L-glutamate
-
aromatic aminotransferase from strain CB 60 and CB 6
-
?
p-aminophenylserinol + 2-oxoglutarate
3-(p-aminophenyl)-1,3-propanediol + L-glutamate
-
aromatic aminotransferase from strain CB 60 and CB 6
-
?
p-nitrophenylserine + 2-oxoglutarate
3-hydroxy-2-oxo-3-(p-nitrophenyl)propanoic acid + L-glutamate
-
aromatic aminotransferase from strain CB 60 and CB 6
-
?
phenylpyruvate + L-glutamate
L-phenylalanine + 2-oxoglutarate
-
-
-
?
prephenate + L-tryptophan
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 3-indole-2-oxopropanoate
-
-
-
?
2,4-dioxo-4-phenylbutyric acid + L-Asp
(2S)-2-amino-4-oxo-4-phenylbutyric acid + oxaloacetate
-
-
-
-
?
2,4-dioxo-4-phenylbutyric acid + L-Asp
(2S)-2-amino-4-oxo-4-phenylbutyric acid + oxaloacetate
-
-
-
-
?
2-oxo-4-phenylbut-3-enoic acid + L-Asp
(3E,2S)-2-amino-4-phenylbutenoic acid + oxaloacetate
-
-
-
-
?
2-oxo-4-phenylbut-3-enoic acid + L-Asp
(3E,2S)-2-amino-4-phenylbutenoic acid + oxaloacetate
-
-
-
-
?
2-oxo-4-phenylbutyrate + L-Asp
2-amino-4-phenylbutyrate + oxaloacetate
-
-
-
-
?
2-oxo-4-phenylbutyrate + L-Asp
2-amino-4-phenylbutyrate + oxaloacetate
-
-
-
-
?
2-oxo-4-phenylbutyrate + L-Glu
2-amino-4-phenylbutyrate + 2-oxoglutarate
-
-
-
-
?
2-oxo-4-phenylbutyrate + L-Glu
2-amino-4-phenylbutyrate + 2-oxoglutarate
-
-
-
-
?
2-oxo-4-phenylbutyrate + L-Phe
2-amino-4-phenylbutyrate + phenylpyruvate
-
-
-
-
?
2-oxo-4-phenylbutyrate + L-Phe
2-amino-4-phenylbutyrate + phenylpyruvate
-
-
-
-
?
2-oxo-4-phenylbutyric acid + L-aspartate
L-homophenylalanine + oxaloacetate
-
-
99% enantiomeric excess of L-homophenylalanine
?
2-oxo-4-phenylbutyric acid + L-aspartate
L-homophenylalanine + oxaloacetate
-
-
99% enantiomeric excess of L-homophenylalanine
?
2-oxoglutarate + Asp
L-glutamate + 2-oxosuccinic acid
-
aromatic aminotransferase AT-1
-
-
?
2-oxoglutarate + Asp
L-glutamate + 2-oxosuccinic acid
-
aromatic aminotransferase AT-2
-
-
?
2-oxoglutarate + Glu
Glu + 2-oxoglutarate
-
aromatic aminotransferase AT-1
-
-
?
2-oxoglutarate + Glu
Glu + 2-oxoglutarate
-
aromatic aminotransferase AT-2
-
-
?
2-oxoglutarate + L-Phe
L-Glu + phenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
2-oxoglutarate + L-Phe
L-Glu + phenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
2-oxoglutarate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
-
r
2-oxoglutarate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
r
2-oxoglutarate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
r
2-oxoglutarate + L-tryptophan
L-glutamate + 3-indole-2-oxopropanoate
-
-
-
-
r
2-oxoglutarate + L-tryptophan
L-glutamate + 3-indole-2-oxopropanoate
-
-
-
r
2-oxoglutarate + L-tryptophan
L-glutamate + 3-indole-2-oxopropanoate
-
-
-
r
2-oxoglutarate + L-tryptophan
L-glutamate + indolepyruvate
-
best substrates, enzyme is highly specific for Trp and 2-oxoglutarate as amino group donor and acceptor, respectively
-
-
?
2-oxoglutarate + L-tryptophan
L-glutamate + indolepyruvate
-
best substrates, enzyme is highly specific for Trp and 2-oxoglutarate as amino group donor and acceptor, respectively
-
-
?
2-oxoglutarate + L-tyrosine
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
-
r
2-oxoglutarate + L-tyrosine
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
r
2-oxoglutarate + L-tyrosine
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
r
2-oxoglutarate + Trp
L-glutamate + 3-indole-2-oxopropanoate
at 2.5 mM, 69% of the amine donor activity of Phe
-
-
?
2-oxoglutarate + Trp
L-glutamate + 3-indole-2-oxopropanoate
Trp, at 2.5 mM, 37.2% of the amine donor activity of Phe. 2-Oxoglutarate, at 0.25 mM 19% of the amine acceptor activity of phenylpyruvate
-
-
?
2-oxoglutarate + Tyr
L-glutamate + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
2-oxoglutarate + Tyr
L-glutamate + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
4-hydroxyphenylpyruvate + Asp
Tyr + 2-oxosuccinate
-
aromatic aminotransferase AT-1
-
-
?
4-hydroxyphenylpyruvate + Asp
Tyr + 2-oxosuccinate
-
aromatic aminotransferase AT-2
-
-
?
4-hydroxyphenylpyruvate + Glu
Tyr + 2-oxoglutarate
-
aromatic aminotransferase AT-1
-
-
?
4-hydroxyphenylpyruvate + Glu
Tyr + 2-oxoglutarate
-
aromatic aminotransferase AT-2
-
-
?
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
-
?
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
?
4-hydroxyphenylpyruvate + L-tryptophan
L-tyrosine + 3-indole-2-oxopropanoate
-
-
-
?
4-hydroxyphenylpyruvate + L-tryptophan
L-tyrosine + 3-indole-2-oxopropanoate
-
-
-
?
4-hydroxyphenylpyruvate + L-tryptophan
L-tyrosine + 3-indole-2-oxopropanoate
-
-
-
?
4-hydroxyphenylpyruvate + Phe
tyr + phenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
4-hydroxyphenylpyruvate + Phe
tyr + phenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
4-hydroxyphenylpyruvate + Phe
tyr + phenylpyruvate
Phe, best amine donor. 4-hydroxyphenylpyruvate, at 0.25 mM 83% of the amine acceptor activity of phenylpyruvate
-
-
?
4-hydroxyphenylpyruvate + Phe
tyr + phenylpyruvate
Phe, best amine donor. 4-hydroxyphenylpyruvate, at 0.25 mM 99% of the amine acceptor activity of phenylpyruvate
-
-
?
4-hydroxyphenylpyruvate + Tyr
Tyr + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
4-hydroxyphenylpyruvate + Tyr
Tyr + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
alpha-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
-
r
alpha-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
r
alpha-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
-
-
-
r
alpha-ketomethiobutyrate + L-glutamine
2-oxoglutaramide + L-methionine
-
36% of activity with phenylalanine
-
-
?
alpha-ketomethiobutyrate + L-glutamine
2-oxoglutaramide + L-methionine
-
best amino donor
-
?
alpha-ketomethiobutyrate + L-glutamine
2-oxoglutaramide + L-methionine
-
18% of activity with phenylalanine
-
-
?
alpha-ketomethiobutyrate + L-phenylalanine
L-methionine + phenylpyruvate
-
best amino donor
-
?
alpha-ketomethiobutyrate + L-phenylalanine
L-methionine + phenylpyruvate
-
-
-
?
alpha-ketomethiobutyrate + L-phenylalanine
L-methionine + phenylpyruvate
-
best amino donor
-
?
alpha-ketomethiobutyrate + L-tryptophan
L-methionine + indolepyruvate
-
-
-
?
alpha-ketomethiobutyrate + L-tryptophan
L-methionine + indolepyruvate
-
-
-
?
alpha-ketomethiobutyrate + L-tryptophan
L-methionine + indolepyruvate
-
-
-
?
alpha-ketomethiobutyrate + L-tyrosine
L-methionine + hydroxyphenylpyruvate
-
-
-
?
alpha-ketomethiobutyrate + L-tyrosine
L-methionine + hydroxyphenylpyruvate
-
-
-
?
alpha-ketomethiobutyrate + L-tyrosine
L-methionine + hydroxyphenylpyruvate
-
-
-
?
alpha-ketomethiobutyrate + phenylalanine
methionine + phenylpyruvate
-
best amino donor
-
-
?
alpha-ketomethiobutyrate + phenylalanine
methionine + phenylpyruvate
-
best amino donor
-
-
?
alpha-ketomethiobutyrate + tryptophan
methionine + indolepyruvate
-
-
-
-
?
alpha-ketomethiobutyrate + tryptophan
methionine + indolepyruvate
-
-
-
-
?
alpha-ketomethiobutyrate + tyrosine
methionine + hydroxyphenylpyruvate
-
probably involved in the recycling of methionine after the synthesis of polyamines
-
-
?
alpha-ketomethiobutyrate + tyrosine
methionine + hydroxyphenylpyruvate
-
probably involved in the recycling of methionine after the synthesis of polyamines
-
-
?
an aromatic amino acid + 2-oxoglutarate
an aromatic oxo acid + L-glutamate
-
-
-
-
r
an aromatic amino acid + 2-oxoglutarate
an aromatic oxo acid + L-glutamate
-
-
-
-
?
an aromatic amino acid + 2-oxoglutarate
an aromatic oxo acid + L-glutamate
-
-
-
-
?
an aromatic amino acid + 2-oxoglutarate
an aromatic oxo acid + L-glutamate
-
-
-
-
?
aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
3.1% of the activity with phenylalanine
-
?
aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
weak activity
-
r
diphenylpyruvate + L-phenylalanine
L-diphenylalanine + phenylpyruvate
-
Y66L AroATEs produces enantiomerically pure L-diphenylalanine with 23% conversion yield for 10 h, whereas Y66A, Y66V, and Y66F AroATEs are not able to catalyze the transamination reaction. The Y66F and Y66L AroATEs show amino donor specificity toward L-phenylalanine with 42% and 38% enzymatic activity of the wild-type AroATEs, respectively. The forward half-reaction between L-phenylalanine and PLP is observed with the mutant enzymes Y66F and Y66L AroATEs. The backward half-reaction between diphenylpyruvate and PMP enzyme is only detected with Y66L AroATEs
-
-
?
diphenylpyruvate + L-phenylalanine
L-diphenylalanine + phenylpyruvate
-
Y66L AroATEs produces enantiomerically pure L-diphenylalanine with 23% conversion yield for 10 h, whereas Y66A, Y66V, and Y66F AroATEs are not able to catalyze the transamination reaction. The Y66F and Y66L AroATEs show amino donor specificity toward L-phenylalanine with 42% and 38% enzymatic activity of the wild-type AroATEs, respectively. The forward half-reaction between L-phenylalanine and PLP is observed with the mutant enzymes Y66F and Y66L AroATEs. The backward half-reaction between diphenylpyruvate and PMP enzyme is only detected with Y66L AroATEs
-
-
?
L-alanine + alpha-ketomethiobutyrate
pyruvate + L-methionine
-
-
-
?
L-alanine + alpha-ketomethiobutyrate
pyruvate + L-methionine
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
r
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
-
-
-
?
L-aspartate + alpha-ketomethiobutyrate
oxaloacetate + L-methionine
-
-
-
?
L-aspartate + alpha-ketomethiobutyrate
oxaloacetate + L-methionine
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
?
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
-
-
-
-
?
L-cysteine + alpha-ketomethiobutyrate
2-oxo-3-thiopropanoate + L-methionine
-
-
-
?
L-cysteine + alpha-ketomethiobutyrate
2-oxo-3-thiopropanoate + L-methionine
-
-
-
?
L-glutamate + 2-oxo-4-phenylbutyrate
L-homophenylalanine + 2-oxoglutarate
-
-
-
-
r
L-glutamate + 2-oxo-4-phenylbutyrate
L-homophenylalanine + 2-oxoglutarate
-
-
-
-
r
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
r
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
r
L-glutamate + phenylglyoxylate
L-phenylglycine + 2-oxoglutarate
-
-
-
-
r
L-glutamate + phenylglyoxylate
L-phenylglycine + 2-oxoglutarate
-
-
-
-
r
L-glutamate + phenylpyruvate
2-oxoglutarate + L-phenylalanine
-
-
-
r
L-glutamate + phenylpyruvate
2-oxoglutarate + L-phenylalanine
-
-
-
r
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
28% of activity with L-tyrosine
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
27.8% of activity with phenylalanine
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
weak activity
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
0.6% of activity with phenylalanine
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
weak activity
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
very low activity with L-aspartate, L-valine and L-isoleucine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
completely inactive with D-isomers of aromatic amino acids
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
completely inactive with D-isomers of aromatic amino acids
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
completely inactive with D-isomers of aromatic amino acids
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
specificities of isoenzymes: AAT I, AAT II, AAT III
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
various combinations of keto acids and amino acids
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
specificities of isoenzymes AT-I and AT-II
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
various combinations of keto acids and amino acids
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
specificities of isoenzymes AT-I and AT-II
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
enzyme may be involved in the degradation of amino acids to aroma compounds
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
enzyme also reacts with 2-aminooctanoate and 2-aminoheptanoate
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
best substrate of AroAT II
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
AroAT I and II may be involved in amino acid degradation
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
best amino acid substrate, specific for 2-oxoglutarate, little or no activity with glyoxylate, pyruvate, 2-oxo-4-methylthiobutyrate and alpha-ketoadipate
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
may play a catabolic role in proteolysis, generation of glutamate
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
various combinations of keto acids and amino acids
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
specificities of isoenzymes AT-I and AT-II
-
r
L-phenylalanine + glyoxylate
phenylpyruvate + glycine
-
-
-
r
L-phenylalanine + oxaloacetate
phenylpyruvate + L-aspartate
-
3.5% of activity with 2-oxoglutarate
-
?
L-phenylalanine + oxaloacetate
phenylpyruvate + L-aspartate
-
-
-
?
L-phenylalanine + oxaloacetate
phenylpyruvate + L-aspartate
-
-
-
?
L-phenylalanine + oxaloacetate
phenylpyruvate + L-aspartate
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
2.1% of the activity with 2-oxoglutarate
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
weak activity
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
39.7% of activity with phenylalanine
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
at about 25% of the rate with L-phenylalanine
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
best amino donor, reverse reaction at 30% of the forward reaction, enzyme is able to transaminate alanine, arginine, aspartate, leucine and lysine to a lesser extent, enzyme uses oxaloacetate oxaloacetate and pyruvate as amino acceptors
-
r
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
-
-
-
?
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
-
-
-
?
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
-
-
-
?
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
-
-
-
-
?
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
at about 25% of the rate with L-phenylalanine
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
best amino donor
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
i.e. 3-(4-hydroxyphenyl)-2-oxobutanoate + L-Glu
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
23.7% of activity with phenylalanine
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
reverse reaction at 40% of the forward reaction
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
oxaloacetate + Asp
Asp + oxaloacetate
-
aromatic aminotransferase AT-1
-
-
?
oxaloacetate + Asp
Asp + oxaloacetate
-
aromatic aminotransferase AT-2
-
-
?
oxaloacetate + Glu
Asp + 2-oxoglutarate
-
aromatic aminotransferase AT-1
-
-
?
oxaloacetate + Glu
Asp + 2-oxoglutarate
-
aromatic aminotransferase AT-2
-
-
?
oxaloacetate + L-tryptophan
L-aspartate + indolepyruvate
-
poor amine acceptor
-
-
?
oxaloacetate + L-tryptophan
L-aspartate + indolepyruvate
-
poor amine acceptor
-
-
?
oxaloacetate + Phe
Asp + phenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
oxaloacetate + Phe
Asp + phenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
oxaloacetate + Tyr
Asp + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
oxaloacetate + Tyr
Asp + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
phenylpyruvate + Asp
Phe + 2-oxosuccinate
-
aromatic aminotransferase AT-1
-
-
?
phenylpyruvate + Asp
Phe + 2-oxosuccinate
-
aromatic aminotransferase AT-2
-
-
?
phenylpyruvate + Glu
Phe + 2-oxoglutarate
-
aromatic aminotransferase AT-1
-
-
?
phenylpyruvate + Glu
Phe + 2-oxoglutarate
-
aromatic aminotransferase AT-2
-
-
?
phenylpyruvate + L-Asp
Phe + oxaloacetate
Asp, at 2.5 mM, 62.8% of the amine donor activity of Phe
-
-
?
phenylpyruvate + L-Asp
Phe + oxaloacetate
at 2.5 mM, 61.4% of the amine donor activity of Phe
-
-
?
phenylpyruvate + Phe
Phe + phenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
phenylpyruvate + Phe
Phe + phenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
phenylpyruvate + Tyr
Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
aromatic aminotransferase AT-1
-
-
?
phenylpyruvate + Tyr
Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
aromatic aminotransferase AT-2
-
-
?
phenylpyruvate + Tyr
Phe + 4-hydroxyphenylpyruvate
phenylpyruvate, best amine acceptor. Tyr, at 2.5 mM, 83% of the amine donor activity of Phe
-
-
?
phenylpyruvate + Tyr
Phe + 4-hydroxyphenylpyruvate
phenylpyruvate, best amine acceptor. Tyr, at 2.5 mM, 90% of the amine donor activity of Phe
-
-
?
prephenate + Asp
arogenate + 2-oxosuccinate
-
aromatic aminotransferase AT-1
-
-
?
prephenate + Asp
arogenate + 2-oxosuccinate
-
aromatic aminotransferase AT-2
-
-
?
prephenate + Glu
arogenate + 2-oxoglutarate
-
aromatic aminotransferase AT-1
-
-
?
prephenate + Glu
arogenate + 2-oxoglutarate
-
aromatic aminotransferase AT-2
-
-
?
prephenate + L-glutamate
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
-
-
?
prephenate + L-glutamate
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
highest activity
-
?
prephenate + L-glutamate
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
highest activity
-
?
prephenate + L-glutamate
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
highest activity
-
?
prephenate + Phe
arogenate + phenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
prephenate + Phe
arogenate + phenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
prephenate + Tyr
arogenate + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-1
-
-
?
prephenate + Tyr
arogenate + 4-hydroxyphenylpyruvate
-
aromatic aminotransferase AT-2
-
-
?
pyruvate + L-tryptophan
L-alanine + indolepyruvate
-
poor amine acceptor
-
-
?
pyruvate + L-tryptophan
L-alanine + indolepyruvate
-
poor amine acceptor
-
-
?
additional information
?
-
-
AroH behaves as an aromatic amino acid aminotransferase, but also accepts L-kynurenine and alpha-aminoadipate as amino donors
-
-
-
additional information
?
-
-
enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57
-
-
?
additional information
?
-
enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57
-
-
?
additional information
?
-
-
enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57
-
-
?
additional information
?
-
enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57
-
-
?
additional information
?
-
no activity with L-histidine
-
-
-
additional information
?
-
no activity with L-histidine
-
-
-
additional information
?
-
no activity with L-histidine
-
-
-
additional information
?
-
-
major role of enzyme and of branched chain amino acid transaminase for growth of Lactococcus lactis in milk by degrading intracellular excess isoleucine, enzymes are regulated by nutritional factors
-
-
?
additional information
?
-
-
amino acid aminotransferase catalyzes the first step in the Trp-dependent synthetic pathway. The specific activity of aromatic amino acid aminotransferase is correlated with the concentration of indole-3-acetic acid produced in the presence of Trp but not when Tyr, Phe or Asp is used as a sole nitrogen source
-
-
?
additional information
?
-
-
role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis
-
-
?
additional information
?
-
-
the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis
-
-
?
additional information
?
-
2-oxoglutaric acid is the preferred amino acceptor rather than oxaloacetic acid. Enzyme shows the highest activity toward L-phenylalanine in comparison with L-tryptophan, L-tyrosine, D-phenylalanine, glycine, and L-alanine, and shows 9.7fold higher activity with L-phenylalanine rather than phenylpyruvate as a substrate
-
-
?
additional information
?
-
ARO9 catalyzes the transamination step of the catabolism of aromatic amino acids, mainly tryptophan
-
-
?
additional information
?
-
-
ARO9 catalyzes the transamination step of the catabolism of aromatic amino acids, mainly tryptophan
-
-
?
