2.6.1.7: kynurenine-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about kynurenine-oxoglutarate transaminase, go to the full flat file.

Reaction

Synonyms

AadAT, aminoadipate aminotransferase, aminotransferase, kynurenine, aspartate aminotransferase, Bna3, CCBL2, cysteine conjugate beta-lyase 1, cysteine conjugate beta-lyase 2, glutamic-oxaloacetic transaminase 2, glutamine transaminase K, KAT, KAT I, KAT II, KAT III, KAT IV, KAT-1, KAT-I, KAT-II, KAT2, KAT3, KAT3/GTL/CCBL2, KYAT3, kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, kynurenine aminotransferase 2, kynurenine aminotransferase 3, kynurenine aminotransferase I, kynurenine aminotransferase II, kynurenine aminotransferase III, kynurenine aminotransferase IV, kynurenine aminotransferase-1, kynurenine aminotransferase-I, kynurenine aminotransferase-IV, kynurenine aminotransferases I, kynurenine aminotransferases II, kynurenine pyruvate aminotransferase, kynurenine transaminase (cyclizing), kynurenine-2-oxoglutarate aminotransferase, kynurenine/alpha-aminoadipate aminotransferase, L-kynurenine aminotransferase, mitochondrial aspartate aminotransferase, More, PhKAT, phKAT-II, type II kynurenine aminotransferase

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.7 kynurenine-oxoglutarate transaminase

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Results	in table
5	Activating Compound
1230	AA Sequence
5	Application
1	CAS Registry Number
24	Cloned(Commentary)
42	Cofactor
21	Crystallization (Commentary)
13262	Disease/ Diagnostics
1	Expression
5	General Information
8	General Stability
40	IC50 Value
243	Inhibitors
64	kcat/KM [mM/s]
4	Ki Value [mM]
163	KM Value [mM]
42	Localization
2	Metals/Ions
34	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
385	Organism
4	Pathway
86	PDB ID
38	pH Optimum
6	pH Range
3	pH Stability
1	pI Value
4	Protein Variants
32	Purification (Commentary)
3	Reaction
1	Reaction Type
115	Reference
97	Source Tissue
23	Specific Activity [micromol/min/mg]
8	Storage Stability
291	Substrates and Products (Substrate)
27	Subunits
125	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
4	Temperature Range [°C]
13	Temperature Stability [°C]
93	Turnover Number [1/s]

IC50 Value

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of the Enzyme Summary Page.

IC50 Value on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.315

(2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid

Homo sapiens

Q8N5Z0

at pH 7.4 and 37°C

760036

0.000015 - 0.00003

(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one

2 entries

0.000004 - 0.000005

(3S)-3-amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2(1H)-one

2 entries

0.0045

(6R)-8-cyclopropyl-N-(3,5-dimethylphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.1

(6R)-8-cyclopropyl-N-(4-methoxyphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

IC50 above 0.1 mM, pH and temperature not specified in the publication

758920

0.0024

(6R)-N-(3-chloro-4-fluorophenyl)-8-(cyclopropylmethyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.044

(6R)-N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.0749

(6S)-8-cyclopropyl-N-(3,5-dimethylphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.0155

(6S)-8-cyclopropyl-N-(4-methoxyphenyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.0965

(6S)-N-(3-chloro-4-fluorophenyl)-8-(cyclopropylmethyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.097

(6S)-N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.00091

(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid

Homo sapiens

Q8N5Z0

0.0015 mM or the two enantiomers, pH 8.0, 37°C

722912

0.293

3-(2-carboxyethyl)-5-chloro-1H-indole-2-carboxylic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.666

3-(2-carboxyethyl)-5-nitro-1H-indole-2-carboxylic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.0738

4-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonamide

Homo sapiens

Q8N5Z0

at pH 7.4 and 37°C

760036

0.1128

4-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethylbenzenesulfonamide

Homo sapiens

Q8N5Z0

at pH 7.4 and 37°C

760036

0.02

5-(2-(3-chlorophenyl)hydrazono)-6-ethoxy-6-oxohexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.021

5-(2-(4-bromophenyl)hydrazono)-6-ethoxy-6-oxohexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.02

5-(2-(4-chlorophenyl) hydrazono)-6-ethoxy-6-oxohexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.271

5-bromo-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.034

6-ethoxy-5-(2-(4-iodophenyl)hydrazono)-6-oxohexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.043

6-ethoxy-5-(2-(4-methoxyphenyl)hydrazono)-6-oxohexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.179

6-ethoxy-5-(2-(4-nitrophenyl)hydrazono)-6-oxohexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.033

6-ethoxy-6-oxo-5-(2-p-tolylhydrazono)hexanoic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

0.0131

Aminooxyacetate

Homo sapiens

Q16773

at pH 8.0 and 45°C

760098

0.0057

aminooxyphenylpropionic acid

Homo sapiens

Q16773

at pH 8.0 and 45°C

760098

0.0039

carbenoxolone

Homo sapiens

Q8N5Z0

isoform KAT2, at pH 9.5 and 37°C

760173

0.002

cysteine sulfinate

Homo sapiens

-

pH 7.5, 25°C

722236

0.0263 - 0.2915

estradiol disulfate

3 entries

0.00696

glycyrrhetinic acid

Homo sapiens

Q8N5Z0

isoform KAT2, at pH 9.5 and 37°C

760173

0.00451

glycyrrhizic acid

Homo sapiens

Q8N5Z0

isoform KAT2, at pH 9.5 and 37°C

760173

0.14

Indole-3-propionic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

721808

3

L-phenylalanine

Homo sapiens

Q16773

at pH 8.0 and 45°C

760098

1

L-tryptophan

Homo sapiens

Q16773

at pH 8.0 and 45°C

760098

0.00081

N-(3-chloro-4-methylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.008

N-(3-ethylphenyl)-8-(3-methylbutyl)-9-oxo-2,8-diazaspiro[5.5]undecane-2-carboxamide

Homo sapiens

Q8N5Z0

pH and temperature not specified in the publication

758920

0.000015

(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one

Homo sapiens

Q8N5Z0

flourescence assay, pH 7.5, temperature not specified in the publication

737437

0.00003

(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one

Homo sapiens

Q8N5Z0

mass spectrometry assay, pH 7.5, temperature not specified in the publication

737437

0.000004

(3S)-3-amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2(1H)-one

Homo sapiens

Q8N5Z0

mass spectrometry assay, pH 7.5, temperature not specified in the publication

737437

0.000005

(3S)-3-amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2(1H)-one

Homo sapiens

Q8N5Z0

fluorescence assay, pH 7.5, temperature not specified in the publication

737437

0.0263

estradiol disulfate

Homo sapiens

Q8N5Z0

at pH 7.4 and 37°C

760036

0.0263

estradiol disulfate

Homo sapiens

Q16773, Q8N5Z0

isoform KAT-II, at pH 7.4 and 37°C

760150

0.2915

estradiol disulfate

Homo sapiens

Q16773, Q8N5Z0

isoform KAT-I, at pH 7.4 and 37°C

760150