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2.6.1.7: kynurenine-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about kynurenine-oxoglutarate transaminase, go to the full flat file.

Word Map on EC 2.6.1.7

Reaction

L-kynurenine
+
2-oxoglutarate
=
4-(2-aminophenyl)-2,4-dioxobutanoate
+
L-glutamate

Synonyms

AadAT, aminoadipate aminotransferase, aminotransferase, kynurenine, aspartate aminotransferase, Bna3, CCBL2, cysteine conjugate beta-lyase 1, cysteine conjugate beta-lyase 2, glutamic-oxaloacetic transaminase 2, glutamine transaminase K, KAT, KAT I, KAT II, KAT III, KAT IV, KAT-1, KAT-I, KAT-II, KAT2, KAT3, KAT3/GTL/CCBL2, KYAT3, kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, kynurenine aminotransferase 2, kynurenine aminotransferase 3, kynurenine aminotransferase I, kynurenine aminotransferase II, kynurenine aminotransferase III, kynurenine aminotransferase IV, kynurenine aminotransferase-1, kynurenine aminotransferase-I, kynurenine aminotransferase-IV, kynurenine aminotransferases I, kynurenine aminotransferases II, kynurenine pyruvate aminotransferase, kynurenine transaminase (cyclizing), kynurenine-2-oxoglutarate aminotransferase, kynurenine/alpha-aminoadipate aminotransferase, L-kynurenine aminotransferase, mitochondrial aspartate aminotransferase, More, PhKAT, phKAT-II, type II kynurenine aminotransferase

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.7 kynurenine-oxoglutarate transaminase

Source Tissue

Source Tissue on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
no difference in mRNA levels for KAT-1 when schizophrenic individuals are compared with normal individuals
Manually annotated by BRENDA team
in some parts, only faint expression of isoform KAT II, and occasionally no staining. No association of staining variability for KAT II and localization of Corpora amylacea
Manually annotated by BRENDA team
-
highest activity in cerebral ganglion, low activity in thoracic and abdominal ganglion
Manually annotated by BRENDA team
microglial cells become KAT-I immunoreactive only after treatment with 6-hydroxydopamine
Manually annotated by BRENDA team
-
KAT 1, low activity
Manually annotated by BRENDA team
-
KAT 1, low activity
Manually annotated by BRENDA team
-
oligodendrocyte cell line
Manually annotated by BRENDA team
-
KAT I, low activity
Manually annotated by BRENDA team
no difference in mRNA levels for KAT-1 when schizophrenic individuals are compared with normal individuals
Manually annotated by BRENDA team
the enzyme is generally more expressed in oxidative muscle fibers
Manually annotated by BRENDA team
-
KAT 1, low activity
Manually annotated by BRENDA team
-
KAT 1, low activity
Manually annotated by BRENDA team
-
KAT 1, low activity
Manually annotated by BRENDA team
pars compacta. Neurons and glial cells. Treatment with 6-hydroxydopamine produces loss of the majority of nigral neurons. KAT-I diminished considerably in the remaining neurons. Astrocytes in the substantia nigra express KAT-I under normal conditions, the amount of this enzyme increases after administration of 6-hydroxydopamine. Microglial cells become KAT-I immunoreactive only after treatment with 6-hydroxydopamine
Manually annotated by BRENDA team
-
KAT I, low activity
Manually annotated by BRENDA team
additional information
-
tissue localizations of KAT3/GTL/CCBL2, real-time RT-PCR enzyme expression analysis in tissues of female and male animals, overview. The enzyme is present in both liver and kidney of the mouse, but is much more abundant in the kidney than in the liver
Manually annotated by BRENDA team