2.6.1.85: aminodeoxychorismate synthase

This is an abbreviated version!
For detailed information about aminodeoxychorismate synthase, go to the full flat file.

Reaction

Synonyms

4-amino-4-deoxychorismate synthase, ADC, ADC synthase, ADCS, aminodeoxychorismate synthase, chorismate:L-glutamine amido-ligase, EC 6.3.5.8, PabA, PabAB, PabB, PhzE, PvADCS

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.85 aminodeoxychorismate synthase

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Results	in table
3	Activating Compound
19421	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
2	Crystallization (Commentary)
6	General Information
10	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
18	KM Value [mM]
1	Localization
8	Metals/Ions
4	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
21	Organism
5	Pathway
5	PDB ID
2	pH Optimum
10	Protein Variants
6	Purification (Commentary)
10	Reaction
2	Reaction Type
18	Reference
2	Storage Stability
21	Substrates and Products (Substrate)
6	Subunits
27	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

Engineering

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Engineering on EC 2.6.1.85 - aminodeoxychorismate synthase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

K213A

Escherichia coli

-

subunit PabB, numbering used is based on the EntC protein from Escherichia coli, reduced activity

702371

K213A/Q147K

Escherichia coli

-

subunit PabB, numbering used is based on the EntC protein from Escherichia coli, strongly reduced activity

702371

K274A

Escherichia coli

-

265fold reduction of kcat-value

661933

K274A/L277R/D299E/N303H/I306L/F334Y/C391G

Escherichia coli

P00903

mutant displaying anthranilate synthase activity, the kcat/Kchoris value for anthranilate formation is 25% of the wild-type aminodeoxychorismate synthase value for 4-amino-4-deoxychorismate production

737705

K274R

Escherichia coli

-

640fold reduction of kcat-value

661933

N213V/L214P/K274A/L277R/D299E/N303H/F334Y/P363N/I367L/C391G/G425A

Escherichia coli

P00903

mutant displaying anthranilate synthase activity, is able to produce both 2-amino-2-deoxyisochorismate and anthranilate

737705

N213V/L214P/R259S/K274A/L277R/N303H/F334Y/S366T/C391G/G254A

Escherichia coli

P00903

mutant displaying anthranilate synthase activity, is able to produce both 2-amino-2-deoxyisochorismate and anthranilate

737705

additional information

4 entries

additional information

Phaseolus vulgaris

G1JT92

a single-nucleotide polymorphism (SNP) for PvADCS is identified between the ADCS gene fragment sequences of BAT93 (JN392964) and Jalo EEP558 (JN392965)

759303

additional information

Phaseolus vulgaris

G1JT93

a single-nucleotide polymorphism (SNP) for PvADCS is identified between the ADCS gene fragment sequences of BAT93 (JN392964) and Jalo EEP558 (JN392965)

759303

additional information

Phaseolus vulgaris BAT93

-

a single-nucleotide polymorphism (SNP) for PvADCS is identified between the ADCS gene fragment sequences of BAT93 (JN392964) and Jalo EEP558 (JN392965)

-

additional information

Phaseolus vulgaris Jalo EEP558

-

a single-nucleotide polymorphism (SNP) for PvADCS is identified between the ADCS gene fragment sequences of BAT93 (JN392964) and Jalo EEP558 (JN392965)

-