2.6.1.85: aminodeoxychorismate synthase
This is an abbreviated version!
For detailed information about aminodeoxychorismate synthase, go to the full flat file.
Word Map on EC 2.6.1.85
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2.6.1.85
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folate
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p-aminobenzoate
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anthranilate
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isochorismate
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chorismate-utilizing
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para-aminobenzoic
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amidotransferase
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shikimate
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macrolactone
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biofortification
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enterobactin
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candicidin
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biotechnology
- 2.6.1.85
- folate
- p-aminobenzoate
- anthranilate
- isochorismate
-
chorismate-utilizing
-
para-aminobenzoic
-
amidotransferase
- shikimate
-
macrolactone
-
biofortification
- enterobactin
- candicidin
- biotechnology
Reaction
Synonyms
4-amino-4-deoxychorismate synthase, ADC, ADC synthase, ADCS, aminodeoxychorismate synthase, chorismate:L-glutamine amido-ligase, EC 6.3.5.8, PabA, PabAB, PabB, PhzE, PvADCS
ECTree
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Reaction
Reaction on EC 2.6.1.85 - aminodeoxychorismate synthase
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the enzyme is composed of two parts, PabA and PabB
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
association of PabA and PabB is greatly enhanced by 5 mM glutamine and greatly reduced at cold temperatures
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
in the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+)
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
non linear production of PABA in the ADC synthase-ADC lyase-coupled reaction system, at different glutamine and chorismate concentrations, with limiting PabB
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
mechanism includes nucleophile addition to C2 of chorismate in an SN2'' process
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
omega-amino group of K274 adds to chorismate at C2, leading to elimination of the C4 hydroxyl in an SN2'' displacement reaction. After attack of ammonia to intermediate, another SN2'' displacement expels K274 and forms aminodeoxychorismate
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