2.6.1.87: UDP-4-amino-4-deoxy-L-arabinose aminotransferase

This is an abbreviated version!
For detailed information about UDP-4-amino-4-deoxy-L-arabinose aminotransferase, go to the full flat file.

Reaction

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.87 UDP-4-amino-4-deoxy-L-arabinose aminotransferase

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Results	in table
4056	AA Sequence
2	Cloned(Commentary)
1	Cofactor
1	Localization
2	Natural Substrates/ Products (Substrates)
2	Organism
3	Pathway
3	PDB ID
1	pH Optimum
2	Purification (Commentary)
1	Reaction
2	Reference
4	Substrates and Products (Substrate)
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.6.1.87 - UDP-4-amino-4-deoxy-L-arabinose aminotransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

4 entries

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

Escherichia coli

P77690

ArnB catalyzes the reversible transfer of the amino group from glutamate to the acceptor, uridine 5'-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate), the intermediate that is synthesized by ArnA from UDP-glucuronic acid.the enzyme is highly selective for glutamate as the amine donor, but the equilibrium constant in the direction of UDP-4-amino-4-deoxy-beta-L-arabinose formation is unfavorable

698724

-

-

r

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

Escherichia coli

P77690

the enzyme is highly selective for glutamate as the amine donor, but the equilibrium constant in the direction of UDP-4-amino-4-deoxy-beta-L-arabinose formation is unfavorable. The rate of transamination with L-methionine, L-glutamine, and L-alanine is measurable at 5%, 2%, and 1%, respectively, of the rate observed with L-glutamate

698724

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-

r

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

701247

-

-

r

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

Salmonella enterica subsp. enterica serovar Typhimurium

-

lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway

701247

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-

r