2.6.1.9: histidinol-phosphate transaminase

This is an abbreviated version!
For detailed information about histidinol-phosphate transaminase, go to the full flat file.

Word Map on EC 2.6.1.9

2.6.1.9

aminotransferases

5'-phosphate

auxotrophic

transamination

aldimine

plp-dependent

pyridoxamine

Reaction

Synonyms

aminotransferase, histidinol phosphate, AtHPA1, glutamic-imidazoleacetol phosphate transaminase, HisC, HisC2, histidine:imidazoleacetol phosphate transaminase, histidinol phosphate aminotransferase, histidinol-phosphate aminotransferase, HspAT, IAP transaminase, imidazoleacetol phosphate transaminase, imidazolylacetolphosphate aminotransferase, imidazolylacetolphosphate transaminase, L-histidinol phosphate aminotransferase, Rv1600

ECTree

2 Transferases

2.6 Transferring nitrogenous groups

2.6.1 Transaminases

2.6.1.9 histidinol-phosphate transaminase

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Results	in table
1	Activating Compound
45158	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
13	Cofactor
8	Crystallization (Commentary)
7	Inhibitors
3	kcat/KM [mM/s]
31	KM Value [mM]
1	Localization
10	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
29	Organism
11	Pathway
51	PDB ID
6	pH Optimum
1	pH Range
2	pH Stability
10	Protein Variants
11	Purification (Commentary)
5	Reaction
1	Reaction Type
23	Reference
1	Renatured (Commentary)
1	Source Tissue
19	Specific Activity [micromol/min/mg]
5	Storage Stability
54	Substrates and Products (Substrate)
8	Subunits
23	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
5	Temperature Stability [°C]
22	Turnover Number [1/s]

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Engineering on EC 2.6.1.9 - histidinol-phosphate transaminase

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N99D

Corynebacterium glutamicum

Q9KJU4

6fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate

684151

Y123F

Corynebacterium glutamicum

Q9KJU4

4fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate

684151

Y21F

Corynebacterium glutamicum

Q9KJU4

10fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate

684151

Y257F

Corynebacterium glutamicum

Q9KJU4

5fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate

K214A

increased pKa

N157A

increased pKa

N157A/R335L

increased pKa

R335L

increased pKa

Y127F