2.6.1.90: dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
This is an abbreviated version!
For detailed information about dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase, go to the full flat file.
Word Map on EC 2.6.1.90
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2.6.1.90
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sulfolobus
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solfataricus
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transglycosylation
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beta-glucosides
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beta-d-galactoside
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amygdalin
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3.2.1.21
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glycone
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beta-d-fucoside
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synthesis
- 2.6.1.90
-
sulfolobus
-
solfataricus
-
transglycosylation
-
beta-glucosides
- beta-d-galactoside
- amygdalin
-
3.2.1.21
-
glycone
- beta-d-fucoside
- synthesis
Reaction
Synonyms
FdtB, RavAMT, TDP-3-keto-6-deoxy-D-galactose-3-aminotransferase
ECTree
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Application
Application on EC 2.6.1.90 - dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
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synthesis
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synthesis of TDP-D-ravidosamine, necessary for future in vitro glycosylation assays. TDP-D-ravidosamine is the anticipated sugar donor substrate of RavGT (the glycosyltransferase that links D-ravidosamine to the polyketide derived backbone defuco-gilvocarcin V). Defuco-gilvocarcin V exhibits superior anticancer/antibacterial activities
synthesis
engineering of Escherichia coli to divert the flow of carbon flux from glucose-1-phosphate to thymidine diphosphate 4-oxo 6-deoxy-D-glucose (dTKDG), an intermediate of various dTDP-sugars. Glucose phosphate isomerase, glucose-6-phosphate dehydrogenase and uridylyltransferase genes are deleted while dTDP-D-glucose synthase and dTDP-D-glucose 4,6-dehydratase are overexpressed to produce a pool of dTKDG in the cell cytosol. The flow of dTKDG is further diverted to dTDP-D-viosamine, dTDP 4-amino 4,6-dideoxy-D-galactose, and dTDP 3-amino 3,6-dideoxy-D-galactose sugars using sugar aminotransferases gerB, wecE, and fdtB, respectively, from different sources. These sugar moieties are transferred to the 3-hydroxyl position of quercetin and kaempferol with the help of Arabidopsis thaliana glycosyltransferase ArGT3