2.6.1.95: neomycin C transaminase

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For detailed information about neomycin C transaminase, go to the full flat file.

Reaction

Synonyms

6'-oxoglucosaminyl:L-glutamate aminotransferase, Neo-18, neoB, neoN

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.95 neomycin C transaminase

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Results	in table
2	AA Sequence
2	Cloned(Commentary)
2	Molecular Weight [Da]
4	Organism
5	Pathway
16	PDB ID
1	Purification (Commentary)
1	Reaction
3	Reference
4	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.6.1.95 - neomycin C transaminase

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SYSTEMATIC NAME

IUBMB Comments

2-oxoglutarate:neomycin C aminotransferase

The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group. The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase.