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2.7.1.1: hexokinase

This is an abbreviated version!
For detailed information about hexokinase, go to the full flat file.

Word Map on EC 2.7.1.1

Reaction

ATP
+
D-glucose
=
ADP
 +
D-glucose 6-phosphate

Synonyms

6-phosphate glucose kinase, AtHXK1, ATP-D-hexose 6-phosphotransferase, ATP-D-hexose-6-phosphotransferase, ATP-dependent hexokinase, ATP: D-glucose 6-phosphotransferase, ATP: D-hexose 6-phosphotransferase, ATP:D-glucose 6-phosphotransferase, ATP:D-hexose 6-phosphotransferase, BmHk, brain form hexokinase, CzHXK1, FgHXK1, FgHXK2, GCK, GK, GKbeta, GlcK, glk, GlkB, glucokinase, glucokinase 1, glucokinase B, glucose ATP phosphotransferase, HaHXK1, hexokinase, hexokinase (phosphorylating), hexokinase 1, hexokinase 2, hexokinase 3, hexokinase 6, hexokinase A, hexokinase D, hexokinase Dor, hexokinase I, hexokinase II, hexokinase III, hexokinase IV, hexokinase PI, hexokinase PII, hexokinase type I, hexokinase type II, hexokinase type IV, hexokinase type IV glucokinase, hexokinase, tumor isozyme, hexokinase-1, hexokinase-10, hexokinase-2, hexokinase-4, hexokinase-5, hexokinase-6, hexokinase-7, hexokinase-8, hexokinase-9, hexokinase-II, hexokinase-like 1, hGK, hGK isoform 1, HK, HK II, HK-1, HK-I, HK-R, HK1, HK2, HK4, HKDC1, HKI, HKII, HKIII, HKL1, HPGLK1, HXK, HXK A, HXK II, Hxk1, HXK10, Hxk2, Hxk3, HXK4, HXK5, HXK6, HXK7, HXK8, HXK9, hxkC, hxkD, kinase, hexo- (phosphorylating), KlHxk1, LGK, LGK2, liver glucokinase, liver glucokinase isoform 2, MODY2 glucokinase, More, muscle form hexokinase, NfGlck, NtHXK1, OsHXK, OsHXK1, OsHXK10, OsHXK2, OsHXK3, OsHXK4, OsHXK5, OsHXK6, OsHXK7, OsHXK9, pHXK, plastid hexokinase, PpHXK1, PpHXK10, PpHXK11, PpHXK2, PpHXK3, PpHXK4, PpHXK5, PpHXK6, PpHXK7, PpHXK8, PpHXK9, Rag5p, ROK hexokinase, ScHK2, ScHXK2, SoHXK1, StHK, STK_23540, StoHK, TbHK1, TbHK2, TcHK, TthHK, type II hexokinase, VIT_18s0001g14230, xprF, Zm.5206, Zm.95484

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.1 hexokinase

IC50 Value

IC50 Value on EC 2.7.1.1 - hexokinase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0274
(1R)-6-bromo-3-ethenyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Plasmodium falciparum
pH 7.9, 22°C
0.00206
(22E,24R)-6beta-methoxyergosta-7,9(11),22-triene-3beta,5alpha-diol
Homo sapiens
pH and temperature not specified in the publication
0.00102
2,5-dihydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00027 - 0.0011
2-(4-chlorophenyl)-1,2-benzothiazol-3(2H)-one
0.00016 - 0.0038
2-(4-chlorophenyl)-5-fluoro-1,2-benzothiazol-3(2H)-one
5.75
2-deoxy-D-glucose
Cryptosporidium parvum
pH 7.5, temperature not specified in the publication
0.00207
2-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00023 - 0.002
2-phenyl-1,2-benzothiazol-3(2H)-one
0.000025 - 0.000032
2-[([1,1'-biphenyl]-3-carbonyl)amino]-2,6-dideoxy-6-[(2,3-dichlorobenzene-1-sulfonyl)amino]-D-glucopyranose
0.01452
22E-6beta-methoxyergosta-7,22-diene-3beta,5alpha-diol
Homo sapiens
pH and temperature not specified in the publication
0.00419
3-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
3.39
3-bromo-2-oxopropionic acid
Saccharomyces cerevisiae
-
-
0.026
3-Bromopyruvate
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00108
3-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00589
3-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
-
0.0007
3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00151
4-(2-hydroxyethoxy)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00332
4-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00115
4-butyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00117
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00098
4-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00516
4-fluoro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00521
4-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00053
4-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0031
5-fluoro-N-phenyl-2-sulfanylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0023
5-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1H-indole-2-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00001 - 0.00002
5-[[(2R,3S,4R,5R,6S)-5-[(3-bromophenyl)carbonylamino]-3,4,6-tris(oxidanyl)oxan-2-yl]methylsulfamoyl]-2-methyl-furan-3-carboxylic acid
0.00126
6-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
4.2 - 10
ADP
0.044
atorvastatin
Homo sapiens
pH 8.5, 37°C
0.00552
Benserazide
Homo sapiens
pH and temperature not specified in the publication
0.077
chlorpromazine
Homo sapiens
pH 8.5, 37°C
0.006
clozapine
Homo sapiens
pH 8.5, 37°C
0.033
diltiazem
Homo sapiens
pH 8.5, 37°C
0.0011
dimethyl 2-[[(2E)-3-(4-ethoxyphenyl)prop-2-enoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate
Plasmodium falciparum
pH 7.9, 22°C
0.0019
dimethyl 2-[[4-(3-methylphenoxy)butanoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate
Plasmodium falciparum
pH 7.9, 22°C
0.00001 - 0.00005
ebselen
0.01
enalaprilat
Homo sapiens
pH 8.5, 37°C
0.03
gabapentin
Homo sapiens
pH 8.5, 37°C
0.008
gatifloxacin
Homo sapiens
pH 8.5, 37°C
0.005
indomethacin
Homo sapiens
pH 8.5, 37°C
260 - 280
KCl
0.0758
lauric acid
Trypanosoma brucei
IC50: 0.0758 mM, TbHK1
0.85
lonidamine
Trypanosoma brucei
-
recombinant enzyme
0.086
mangiferin
Eimeria tenella
pH 9.0, 36°C
0.0784
myristic acid
Trypanosoma brucei
IC50: 0.0784 mM, TbHK1
0.00074
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00108
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00172
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00643
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00069
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]quinoline-2-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0048
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]thiophene-2-carbohydrazide
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00026
N,N'-[furan-2,5-diylbis(2-chloro-4,1-phenylene)]diguanidine
Homo sapiens
pH and temperature not specified in the publication
0.00202
N-(4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinecarbonyl]phenyl)cyclopropanecarboxamide
Homo sapiens
pH 8.0, temperature not specified in the publication
240 - 300
NaCl
190 - 230
NH4Cl
0.0624
palmitic acid
Trypanosoma brucei
IC50: 0.0624 mM, TbHK1
0.007
quercetin
Eimeria tenella
pH 9.0, 36°C
0.0045 - 1490
Urea
0.034
Valproic acid
Homo sapiens
pH 8.5, 37°C
0.00817
ZINC03232404
Homo sapiens
pH 8.0, temperature not specified in the publication
0.00939
ZINC03233449
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0101
ZINC39948337
Homo sapiens
pH 8.0, temperature not specified in the publication