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2.7.1.1: hexokinase

This is an abbreviated version!
For detailed information about hexokinase, go to the full flat file.

Word Map on EC 2.7.1.1

Reaction

ATP
+
D-glucose
=
ADP
 +
D-glucose 6-phosphate

Synonyms

6-phosphate glucose kinase, AtHXK1, ATP-D-hexose 6-phosphotransferase, ATP-D-hexose-6-phosphotransferase, ATP-dependent hexokinase, ATP: D-glucose 6-phosphotransferase, ATP: D-hexose 6-phosphotransferase, ATP:D-glucose 6-phosphotransferase, ATP:D-hexose 6-phosphotransferase, BmHk, brain form hexokinase, CzHXK1, FgHXK1, FgHXK2, GCK, GK, GKbeta, GlcK, glk, GlkB, glucokinase, glucokinase 1, glucokinase B, glucose ATP phosphotransferase, HaHXK1, hexokinase, hexokinase (phosphorylating), hexokinase 1, hexokinase 2, hexokinase 3, hexokinase 6, hexokinase A, hexokinase D, hexokinase Dor, hexokinase I, hexokinase II, hexokinase III, hexokinase IV, hexokinase PI, hexokinase PII, hexokinase type I, hexokinase type II, hexokinase type IV, hexokinase type IV glucokinase, hexokinase, tumor isozyme, hexokinase-1, hexokinase-10, hexokinase-2, hexokinase-4, hexokinase-5, hexokinase-6, hexokinase-7, hexokinase-8, hexokinase-9, hexokinase-II, hexokinase-like 1, hGK, hGK isoform 1, HK, HK II, HK-1, HK-I, HK-R, HK1, HK2, HK4, HKDC1, HKI, HKII, HKIII, HKL1, HPGLK1, HXK, HXK A, HXK II, Hxk1, HXK10, Hxk2, Hxk3, HXK4, HXK5, HXK6, HXK7, HXK8, HXK9, hxkC, hxkD, kinase, hexo- (phosphorylating), KlHxk1, LGK, LGK2, liver glucokinase, liver glucokinase isoform 2, MODY2 glucokinase, More, muscle form hexokinase, NfGlck, NtHXK1, OsHXK, OsHXK1, OsHXK10, OsHXK2, OsHXK3, OsHXK4, OsHXK5, OsHXK6, OsHXK7, OsHXK9, pHXK, plastid hexokinase, PpHXK1, PpHXK10, PpHXK11, PpHXK2, PpHXK3, PpHXK4, PpHXK5, PpHXK6, PpHXK7, PpHXK8, PpHXK9, Rag5p, ROK hexokinase, ScHK2, ScHXK2, SoHXK1, StHK, STK_23540, StoHK, TbHK1, TbHK2, TcHK, TthHK, type II hexokinase, VIT_18s0001g14230, xprF, Zm.5206, Zm.95484

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.1 hexokinase

KI Value

KI Value on EC 2.7.1.1 - hexokinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
32.8 - 36
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid)
0.0004 - 0.0012
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate
0.0005 - 0.0028
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate
0.01 - 32
1,5-Anhydro-D-glucitol 6-phosphate
5 - 14
2,3-diphosphoglycerate
0.0028 - 0.006
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate
0.34 - 40.7
2-deoxy-D-glucose
13 - 14
2-phosphoglycerate
1.99
3-bromo-2-oxopropionic acid
-
-
12 - 21
3-phosphoglycerate
0.1 - 0.4
5-thio-D-glucose
50
6-deoxy-D-glucose
-
at 37°C, pH 7.4
0.018 - 7
ADP
0.00065 - 0.031
AMP
0.015
atorvastatin
pH 8.5, 37°C
0.5 - 3.6
ATP
0.15
citrate
-
-
4.5
Cr(III)-ATP
-
pH 6.9, 30°C, versus MgATP2-
0.23
D-fructose
-
inhibition with respect to glucose
2.5 - 4.6
D-fructose 1,6-diphosphate
0.5 - 0.88
D-fructose 6-phosphate
2.1 - 11
D-glucosamine
0.033 - 3
D-Glucose 1,6-bisphosphate
0.04 - 22
D-glucose 1,6-diphosphate
0.015 - 4.1
D-glucose 6-phosphate
0.06
D-mannose
-
glucokinase
0.85 - 80
D-xylose
2.5
dihydroxyacetonephosphate
-
hexokinase III, at 30°C, pH 7.2
0.009 - 0.7
diphosphate
0.0000128 - 0.000113
GK regulatory protein
-
0.4
glucose 1,6-disphosphate
-
IC50
13 - 15
glucose 6-phosphate
-
hexokinase Ia, Ib and Ic, at 37°C, pH 7.2
0.015
indomethacin
pH 8.5, 37°C
0.5 - 20
mannoheptulose
9 - 36
Mg2+
3 - 7.8
MgADP-
0.3 - 0.7
N-acetyl-D-glucosamine
0.63 - 0.8
N-acetylglucosamine
50
N-acetylmannosamine
-
at 37°C, pH 7.4
4.87 - 9.97
Ni2+
0.0035 - 1.6
palmitoyl-CoA
5.3 - 60
phosphate
8
phosphoenolpyruvate
-
hexokinase III, at 30°C, pH 7.2
0.012
trehalose 6-phosphate
pH 7.5, 37°C
3020 - 3021
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid)
22 - 2282
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid)
additional information
additional information
-