Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.1: hexokinase

This is an abbreviated version!
For detailed information about hexokinase, go to the full flat file.

Word Map on EC 2.7.1.1

Reaction

ATP
+
D-glucose
=
ADP
+
D-glucose 6-phosphate

Synonyms

6-phosphate glucose kinase, AtHXK1, ATP-D-hexose 6-phosphotransferase, ATP-D-hexose-6-phosphotransferase, ATP-dependent hexokinase, ATP: D-glucose 6-phosphotransferase, ATP: D-hexose 6-phosphotransferase, ATP:D-glucose 6-phosphotransferase, ATP:D-hexose 6-phosphotransferase, BmHk, brain form hexokinase, CzHXK1, FgHXK1, FgHXK2, GCK, GK, GKbeta, GlcK, glk, GlkB, glucokinase, glucokinase 1, glucokinase B, glucose ATP phosphotransferase, HaHXK1, hexokinase, hexokinase (phosphorylating), hexokinase 1, hexokinase 2, hexokinase 3, hexokinase 6, hexokinase A, hexokinase D, hexokinase Dor, hexokinase I, hexokinase II, hexokinase III, hexokinase IV, hexokinase PI, hexokinase PII, hexokinase type I, hexokinase type II, hexokinase type IV, hexokinase type IV glucokinase, hexokinase, tumor isozyme, hexokinase-1, hexokinase-10, hexokinase-2, hexokinase-4, hexokinase-5, hexokinase-6, hexokinase-7, hexokinase-8, hexokinase-9, hexokinase-II, hexokinase-like 1, hGK, hGK isoform 1, HK, HK II, HK-1, HK-I, HK-R, HK1, HK2, HK4, HKDC1, HKI, HKII, HKIII, HKL1, HPGLK1, HXK, HXK A, HXK II, Hxk1, HXK10, Hxk2, Hxk3, HXK4, HXK5, HXK6, HXK7, HXK8, HXK9, hxkC, hxkD, kinase, hexo- (phosphorylating), KlHxk1, LGK, LGK2, liver glucokinase, liver glucokinase isoform 2, MODY2 glucokinase, More, muscle form hexokinase, NfGlck, NtHXK1, OsHXK, OsHXK1, OsHXK10, OsHXK2, OsHXK3, OsHXK4, OsHXK5, OsHXK6, OsHXK7, OsHXK9, pHXK, plastid hexokinase, PpHXK1, PpHXK10, PpHXK11, PpHXK2, PpHXK3, PpHXK4, PpHXK5, PpHXK6, PpHXK7, PpHXK8, PpHXK9, Rag5p, ROK hexokinase, ScHK2, ScHXK2, SoHXK1, StHK, STK_23540, StoHK, TbHK1, TbHK2, TcHK, TthHK, type II hexokinase, VIT_18s0001g14230, xprF, Zm.5206, Zm.95484

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.1 hexokinase

Source Tissue

Source Tissue on EC 2.7.1.1 - hexokinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
very low expression
Manually annotated by BRENDA team
-
type I isozyme, type II isozyme
Manually annotated by BRENDA team
-
obtained from hamster lesion
Manually annotated by BRENDA team
-
153-306 times higher overexpression in rat AS-30D hepatoma cells than in normal freshly isolated rat hepatocytes. The enhanced glycolytic flux in fast-growth tumor cells is controlled by an overproduced, but glucose 6-phosphate-inhibited hexokinase
Manually annotated by BRENDA team
-
contains only hexokinase I
Manually annotated by BRENDA team
-
TbHK1 is essential to the bloodstream form. Silencing the gene for 4 days reduces cellular hexokinase about 60% and leads to parasite death
Manually annotated by BRENDA team
-
the contribution of glucokinase to total glucose-phosphorylating activity is of 12.4% in the brainstem
Manually annotated by BRENDA team
vascular starch sheath
Manually annotated by BRENDA team
the enzyme is expressed at high level in cancer cells compared with normal cells
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team
-
high hexokinase activity
Manually annotated by BRENDA team
ventricular myocyte
Manually annotated by BRENDA team
glucokinase is continuously expressed during the all growth stages, and the peak value for glucokinase activity occurrs in the stationary growth phase before spores form
Manually annotated by BRENDA team
high expression in surface epithelium. Very low expression in crypt base epithelium
Manually annotated by BRENDA team
-
the superoxide dismutase, catalase and glutathione reductase activities are higher during embryo cellularization, at the end of embryogenesis and during embryo segmentation, respectively. All of the enzymes are stimulated by polyphosphate P3, which is inhibitory to hexokinase
Manually annotated by BRENDA team
very low expression
Manually annotated by BRENDA team
intermediate expression in suprabasal squamous epithelium. Low expression in basal layer
Manually annotated by BRENDA team
-
no glucokinase transcript detected. Activity declines with both fasting and refeeding
Manually annotated by BRENDA team
-
during anoxia, an increase in Km for ATP and a decrease in Vmax for anoxic snail hexokinase are consistent with a less active enzyme
Manually annotated by BRENDA team
moderate activity
Manually annotated by BRENDA team
-
human glioblastoma multiforme shows increased HK2 expression, correlating with poor overall survival
Manually annotated by BRENDA team
-
70-80% hexokinase III, 20-30% hexokinase I
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team
-
overproduction of hexokinase
Manually annotated by BRENDA team
most abundant expression in hepatic cecum, testis and ovary
Manually annotated by BRENDA team
-
AS-30D, highly glycolytic tumor cells
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
pancreatic islets of Langerhans cells: hexokinase I and IV mRNA in beta cells, not type II and III, but HK I activity probably originates mainly from contaminating pancreatic exocrine cells
Manually annotated by BRENDA team
high expression in alveolar macrophages. Intermediate expression in bronchial epithelium. very low expression in alveolar lining cells
Manually annotated by BRENDA team
Plasmodium falciparum hexokinase is associated with the membrane via its C-terminal hydrophobic sequence, and this membrane association improves the efficiency of glucose phosphorylation immediately upon entering the host cell. Plasmodium hexokinase ensures a dramatic increase in reduced glutathione production in infected erythrocytes
Manually annotated by BRENDA team
-
activity significantly decreases with fasting. Activity in refed fish is higher than that of fed fish
Manually annotated by BRENDA team
-
mouse mammary tumour cell
Manually annotated by BRENDA team
-
glucose-grown
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team
-
key role for hexokinase activity and/or localization to the mitochondria in the regulation of neurite outgrowth in cultured adult sensory neurons
Manually annotated by BRENDA team
-
Novikoff ascites-hepatoma cells, hexokinases A, B and C, but not D
Manually annotated by BRENDA team
most abundant expression in hepatic cecum, testis and ovary
Manually annotated by BRENDA team
-
specific activity increases with the aging of promastigote culture (related to glucose consumption). The level of the hexokinase protein remains constant
Manually annotated by BRENDA team
intermediate expression in basal cells. Low to intermediate expression in stromal cells. Low expression in gland epithelium
Manually annotated by BRENDA team
expression and activity levels are significantly increased in nondiapause-destined pupae compared with those of diapause-destined pupae
Manually annotated by BRENDA team
-
type III isozyme
Manually annotated by BRENDA team
-
enzyme is located in either head and tail, in the latter in peri- and post-acrosomal zones
Manually annotated by BRENDA team
high expression in parietal cells and chief cells. Intermediate expression in superficial foveolar epithelium
Manually annotated by BRENDA team
low expression in sweat gland, intermediate expression in sweat gland duct
Manually annotated by BRENDA team
-
activity in refed fish is higher than that of fed fish. Activity in refed fish is higher than that of fed fish
Manually annotated by BRENDA team
intermediate to high expression
Manually annotated by BRENDA team
-
uninfective procyclic forms and haematozoic, animal-infective blood-stream forms of Trypanosoma congolense
Manually annotated by BRENDA team
-
mouse lymphoma cell
Manually annotated by BRENDA team
additional information