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2'-dATP + D-glucose
2'-dADP + D-glucose 6-phosphate
2-fluoro-2-deoxy-D-glucose + ATP
2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP
ATP + 1,5-anhydro-D-glucitol
ADP + 1,5-anhydro-D-glucitol 6-phosphate
-
weak
-
-
?
ATP + 1-thio-D-glucose
ADP + 1-thio-D-glucose 6-phosphate
-
isoenzyme II, weak
-
-
?
ATP + 2-deoxy-2-fluoro-D-glucose
ADP + 2-deoxy-2-fluoro-D-glucose 6-phosphate
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
ATP + 3-deoxy-3-amino-D-glucose
ADP + 3-deoxy-3-amino-D-glucose 6-phosphate
-
isoenzyme II, weak
-
-
?
ATP + 5-thio-D-glucose
ADP + 5-thio-D-glucose 6-phosphate
ATP + beta-D-glucose
ADP + beta-D-glucose 6-phosphate
-
-
-
-
?
ATP + D-allose
ADP + D-allose 6-phosphate
ATP + D-fructose
?
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
ATP + D-galactose
?
Q56VN6
-
-
-
?
ATP + D-galactose
ADP + D-galactose 6-phosphate
-
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
ATP + D-glucose
ADP + D-glucose 6-phosphate
ATP + D-hexose
ADP + D-hexose 6-phosphate
-
-
-
-
?
ATP + D-maltose
?
Q56VN6
-
-
-
?
ATP + D-mannosamine
ADP + D-mannosamine 6-phosphate
ATP + D-mannose
?
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
ATP + hexose
ADP + hexose 6-phosphate
-
-
-
-
?
ATP + mannoheptulose
?
-
sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 6-phosphate
-
sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
D-fructose + ATP
ADP + D-fructose 6-phosphate
D-fructose + ATP
D-fructose 6-phosphate + ADP
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
D-glucose + ATP
ADP + D-glucose 6-phosphate
D-glucose + ATP
D-glucose 6-phosphate + ADP
D-mannose + ATP
ADP + D-mannose 6-phosphate
GTP + D-glucose
GDP + D-glucose 6-phosphate
hexose + ATP
ADP + hexose 6-phosphate
-
-
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
N-acetyl-D-glucosamine + ATP
ADP + N-acetyl-D-glucosamine 6-phosphate
-
erythrocyte enzyme, 32.6% of the activity with glucose
-
-
?
TTP + D-glucose
TDP + D-glucose 6-phosphate
UTP + D-glucose
UDP + D-glucose 6-phosphate
additional information
?
-
2'-dATP + D-glucose
2'-dADP + D-glucose 6-phosphate
-
73-80% of the activity with ATP, isoenzyme Hex A, B, C
-
-
?
2'-dATP + D-glucose
2'-dADP + D-glucose 6-phosphate
-
73% of the activity with ATP
-
-
?
2'-dATP + D-glucose
2'-dADP + D-glucose 6-phosphate
-
Hex A: 73% of the activity with ATP, Hex B: 76% of the activity with ATP, Hex C: 80% of the activity with ATP
-
-
?
2-fluoro-2-deoxy-D-glucose + ATP
2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP
-
-
-
?
2-fluoro-2-deoxy-D-glucose + ATP
2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP
-
-
-
?
ATP + 2-deoxy-2-fluoro-D-glucose
ADP + 2-deoxy-2-fluoro-D-glucose 6-phosphate
-
-
-
?
ATP + 2-deoxy-2-fluoro-D-glucose
ADP + 2-deoxy-2-fluoro-D-glucose 6-phosphate
-
good substrate
-
-
?
ATP + 2-deoxy-2-fluoro-D-glucose
ADP + 2-deoxy-2-fluoro-D-glucose 6-phosphate
-
good substrate
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
30% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
Hex A: 93% of the activity with glucose, Hex B: 51% of the activity with glucose, Hex C: 48% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
93% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
Hex A: 93% of the activity with glucose, Hex B: 51% of the activity with glucose, Hex C: 48% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
Hex Ia: 95% of the activity with glucose, Hex Ib: 99% of the activity with glucose, Hex Ic: 74% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
hexokinase I: as effective as glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
17% of activity with D-fructose at 50 mM substrate concentration
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
hexokinase Ia: 65% of the activity with glucose, hexokinase Ib: 70% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
54% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
65.7% of the activity with glucose, erythrocyte enzyme
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
84% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
hexokinase III: 151% of the activity with glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
42% of the activity with D-glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
42% of the activity with D-glucose
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
-
-
?
ATP + 5-thio-D-glucose
ADP + 5-thio-D-glucose 6-phosphate
-
very slow phosphorylation
-
-
?
ATP + 5-thio-D-glucose
ADP + 5-thio-D-glucose 6-phosphate
-
very slow phosphorylation
-
-
?
ATP + D-allose
ADP + D-allose 6-phosphate
-
phosphorylation of D-allose at C6 by hexokinase is essential since it up-regulates expression of transcription factor OsABF1
-
-
?
ATP + D-allose
ADP + D-allose 6-phosphate
58% of the activity with D-glucose
-
-
?
ATP + D-allose
ADP + D-allose 6-phosphate
58% of the activity with D-glucose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
isozyme HKI, isozyme HKII is highly specific for D-fructose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
Q56VN6
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
16.6% of the activity with ATP
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
8.6% of the activity with ATP
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
8.6% of the activity with ATP
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
best substrate
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
16% of the activity with D-glucose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
-
-
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
8% of activity with D-fructose at 50 mM substrate concentration
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
-
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
67% of the activity with D-glucose
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
67% of the activity with D-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
involved in glucose catabolism
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
isozyme HKI
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
Q56VN6
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
ATP is the preferred nucleside triphosphate
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
ATP is the preferred nucleside triphosphate
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
641067, 641068, 660810, 660963, 663393, 672188, 672225, 674421, 674942, 677004, 702116, 702119, 702140, 702236, 702314, 702320, 702572, 702666, 703358, 703959, 721535, 721827, 721837, 722237, 723509 -
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
enzyme plays a key role in whole-body glucose homeostasis
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the pancreatic enzyme is imporatnt as glucose sensor in insulin secretion and blood glucose homeostasis, interaction of ATP and glucose during binding to the enzyme
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
control of GK activity and Km through the ratio of distinct conformers (super-open, open, and closed) through either substrate or other ligand binding and/or dissociation
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
hexokinase II displays high affinity for D-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
under physiological conditions D-glucose is the preferred substrate
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
first step in glucose metabolism, pathway overview, isozyme types are differently regulated and catalytically active, isozyme type I is involved in catabolism, while type II and III are involved in anabolism, the activity rate of type I isozyme i correlated with the oxidative phosphorylation rate, overview
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
isozyme hexokinase 2 plays a role in starch and secondary metabolism in starch sheath, xylem parenchyma, guard cells, and root tips
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
enzyme mediates glucose repression
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
39% of activity with D-fructose at 50 mM substrate concentration
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
641070, 641071, 641072, 660949, 660963, 663393, 701997, 702116, 702556, 703129, 704456, 704831, 705268, 705294, 706889 -
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
first step in the process of glycolysis
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
in Sulfolobus tokodaii this is the sole enzyme responsible for the phosphorylation of glucose in vivo
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
in Sulfolobus tokodaii this is the sole enzyme responsible for the phosphorylation of glucose in vivo
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the presence of 0.5 mM glucose induced total hexokinase activity in supernatants from sperm extracts of 1.7 mIU/mg protein, while the same concentration of both fructose, mannose, and sorbitol induced total hexokinase activity from 0.3 mIU/mg protein to 0.60 IU/mg protein. Diluted boar sperm from fresh ejaculates phosphorylates glucose through the hexokinase step much more efficiently than fructose or mannose. This difference facilitates a much more rapid intake of glucose into glycolysis than the other sugars
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
best substrate
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
best substrate
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the enzyme shows a narrow substrate specificity, as it does not display activity towards fructose, mannose or galactose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-mannosamine
ADP + D-mannosamine 6-phosphate
-
fairly good substrate
-
-
?
ATP + D-mannosamine
ADP + D-mannosamine 6-phosphate
-
fairly good substrate
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
Q56VN6
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
97% of the activity with ATP
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
52% of the activity with ATP
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
52% of the activity with ATP
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
poor substrate
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
33% of activity with D-fructose at 50 mM substrate concentration
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
75% of the activity with D-glucose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
11% of the activity with ATP, isoenzyme Hex C, not: isoenzyme Hex A and Hex B
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
35% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
35% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
18% of the activity with ATP
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
Hex B: 5% of the activity with ATP, Hex C: 11% of the activity with ATP, not Hex A
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
MgCTP, hexokinase I: 5% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
35% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
81% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
46.3% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
Hex A: 50% of the activity with glucose, Hex B: 41% of the activity with glucose, Hex C: 134% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
50% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
Hex A: 50% of the activity with glucose, Hex B: 41% of the activity with glucose, Hex C: 134% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
50% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinase I: 130% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
Hex Ia: 100% of the activity with glucose, Hex Ib: 120% of the activity with glucose, Hex Ic: 90% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
70% of the activity with glucose, erythrocyte enzyme
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinase Ia: 69% of the activity with glucose, hexokinase Ib: 42% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
110% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
poor substrate
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinase C
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinases PI and PII phosphorylate fructose 2.5 and 1.5times faster than glucose, glucokinase: very low or no activity
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinases PI and PII phosphorylate fructose 2.5 and 1.5times faster than glucose, glucokinase: very low or no activity
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
higher activity than with glucose or mannose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
higher activity than with glucose or mannose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
higher activity than with glucose or mannose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinase, but not glucokinase
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
HK3: 16% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
HK1: 4% of the activity with glucose, HK2: 3% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
HK3: 5% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
hexokinase III: 12.6% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
79% of the activity with glucose
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
?
D-fructose + ATP
ADP + D-fructose 6-phosphate
-
-
-
-
?
D-fructose + ATP
D-fructose 6-phosphate + ADP
-
fructose metabolism
-
?
D-fructose + ATP
D-fructose 6-phosphate + ADP
-
-
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
44.9% of the activity with glucose
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
Hex A: 19% of the activity with glucose, Hex C: 44% of the activity with glucose, not Hex B
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
Hex A: 19% of the activity with glucose, Hex C: 44% of the activity with glucose, not Hex B
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
-
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
Hex Ia and Ib: 47% of the activity with glucose, Hex Ic: 21% of the activity with glucose
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
hexokinase I: 40% of the activity with glucose
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
-
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
hexokinase Ia: 35% of the activity with glucose, hexokinase Ib: 70% of the activity with glucose
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
erythrocyte enzyme, 43.4% of the activity with glucose
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
-
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
hexokinase III: 35% of the activity with glucose
-
-
?
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
hexokinase bound at type A and B sites of brain mitochondria selectively uses intramitochondrial ATP as substrate, but hexokinase bound at type B sites, after removal of enzyme of type A sites, shows no such selectivity
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
MgATP2-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
specific for ATP
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
the binding of glucose does not depend on ATP, and vice versa
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
the binding of glucose does not depend on ATP, and vice versa
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
good substrate
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
good substrate
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
bound glucose is present as the beta-anomer, glucose binding sites
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
MgATP2-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
absolute requirement for D-glucose
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
MgATP2-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
MgATP2-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
good substrate
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
11% of the activity with fructose
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
59% of the activity with fructose
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
11% of the activity with fructose
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
59% of the activity with fructose
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
hexokinase and glucokinase
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
preferred specificity for glucose
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
specific for ATP
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
preferred specificity for glucose
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
-
-
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
specific for glucose
-
?
D-glucose + ATP
ADP + D-glucose 6-phosphate
-
most active with D-glucose
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
cerebral glycolytic metabolism, mechanisms for regulation of mitochondrial hexokinase activity may depend on the ratio of type A:type B sites
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
isoenzymes are a target for effective control of glucose 6-phosphate formation by energy charge of the cell or by the intracellular level of ATP, ADP and glucose instead of allosteric interconversions of the enzyme
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
initial enzyme of glycolysis
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
at high energy charge HXK1 may be involved in glycolysis and in some biosynthetic processes, e.g. phosphorylating mannose or glucose for the later integration into membrane components, at low energy charge HXK1 could be inhibited by AMP and ADP, and HXK2 would be more active and could keep up glucokinase activity for glycolysis
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
initial enzyme of glycolysis
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glycolytic enzyme
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
hexokinase I governs the rate-limiting step of glycolysis in brain
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
hexokinase I is the pacemaker of glycolysis in brain tissue
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
hexokinase I is a regulated enzyme and serves a critical role in controlling the rate of glycolysis in both brain and red blood cells
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
initial enzyme of glycolysis
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
key enzyme in the control of brain glucose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glycolytic enzyme
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
initial catalytic step of the cerebral glucose metabolism, glucose 6-phosphate represents a major regulatory influence on the in vivo activity
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
hexokinase isoenzymes are particularly important in glycolytic flux and, in addition, hexokinase PII, hexokinase PIIM or both are also responsible for the overall regulation of carbohydrate metabolism, role in glucose repression
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
enzyme of the glucose-phosphate branch of the oxidative pentose phosphate pathway
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
enzyme of the glucose-phosphate branch of the oxidative pentose phosphate pathway
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glucose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
organ- and development-specific changes in the abundance of the various enzyme forms contribute to the regulation of hexose metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
the presence of type III hexokinase enables the adult pig erythrocytes to metabolize low but appreciable amounts of glucose
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
carbohydrate metabolism
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
first step of the glycolytic pathway, physiological function of membrane-bound hexokinase in the tachyzoite: glucose channeling with a glucose/hexose transporter
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
rate-limiting step in the glycolysis
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
rate-limiting step in the glycolysis
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
-
glycolytic enzyme
-
-
?
D-glucose + ATP
D-glucose 6-phosphate + ADP
glycolytic enzyme
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
27.2% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
Hex A: 100% of the activity with glucose, Hex B: 98% of the activity with glucose, Hex C: 44% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
Hex A: 100% of the activity with glucose, Hex B: 98% of the activity with glucose, Hex C: 44% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
HXK1: good substrate, HXK2: much lower phosphorylation rate than of HXK1
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
HXK1: good substrate, HXK2: much lower phosphorylation rate than of HXK1
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
Hex Ia: 78% of the activity with glucose, Hex Ib: 83% of the activity with glucose, Hex Ic: 85% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
hexokinase I: 106% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
82% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
109% of the activity with glucose, erythrocyte enzyme
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
104-105% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
good substrate
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
glucokinase
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
glucokinase
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
42% of the activity with fructose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
23% of the activity with fructose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
23% of the activity with fructose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
42% of the activity with fructose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
HK1: 53% of the activity with glucose, HK2: 22% of the activity with glucose, HK3: 45% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
hexokinase III: 85% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
55% of the activity with glucose
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
?
D-mannose + ATP
ADP + D-mannose 6-phosphate
-
-
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
-
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
19% of the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
19% of the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
-
14% of the activity with ATP
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
-
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
52% of the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
18% of the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
can partially replace ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
-
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
-
35% of the activity with ATP
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
13.5-14% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
MgITP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
hexokinase I: 9% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
30% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
12% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
36% of the activity with ATP, erythrocyte enzyme
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
MgITP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
64% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
64% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
hexokinase III: 24% of the activity with glucose
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
MgITP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
40% of the activity with ATP
-
-
?
TTP + D-glucose
TDP + D-glucose 6-phosphate
-
-
21% of the activity with ATP
-
?
TTP + D-glucose
TDP + D-glucose 6-phosphate
-
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
-
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
23% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
23% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
-
13% of the activity with ATP
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
hexokinase I: 5% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
MgUTP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
14% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
MgUTP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
-
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
37% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
17% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
can partially replace ATP
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
the active site is located in the C-terminal domain
-
-
?
additional information
?
-
-
the active site is located in the C-terminal domain
-
-
?
additional information
?
-
hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
-
-
?
additional information
?
-
-
hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
not: N-acetyl-D-glucosamine
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
not: ITP
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP
-
-
?
additional information
?
-
-
no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP
-
-
?
additional information
?
-
no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP
-
-
?
additional information
?
-
no substrate: D-galactose
-
-
?
additional information
?
-
-
no substrate: D-galactose
-
-
?
additional information
?
-
-
not: fructose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
not: fructose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
structure model of hexokinase I
-
-
?
additional information
?
-
structure model of hexokinase I
-
-
?
additional information
?
-
-
structure model of hexokinase I
-
-
?
additional information
?
-
-
not: N-acetyl-D-glucosamine
-
-
?
additional information
?
-
-
role of the hexokinase III carboxyl-domain in determining the catalytic properties of enzyme
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
the 50 kDa C-terminal half of HK I contains the catalytic domain, the N-terminal half is catalytically inactive
-
-
?
additional information
?
-
-
C-terminal catalytic and N-terminal regulatory domain, detailed structure of hexokinase I, substrate binding sites, models for regulation
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
-
loss of enzyme activity is involved in type 2 diabetes mellitus
-
-
?
additional information
?
-
-
biophysical characterization of the interaction between GK and GKRP and its modulation by physiological and pharmacological effectors
-
-
?
additional information
?
-
the enzyme is the only glucose and fructose phosphorylating enzyme, which is upregulating glucose transport and also mediating glucose repression
-
-
?
additional information
?
-
-
the enzyme is the only glucose and fructose phosphorylating enzyme, which is upregulating glucose transport and also mediating glucose repression
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
the 100 kDa isozymes, displaying internal sequence repetition, may have evolved by gene duplication of a 50 kDa ancestor
-
-
?
additional information
?
-
-
sperm hexokinase p95/116 may serve as cell surface receptor kinase for the zona pellucida glycoprotein ZP3
-
-
?
additional information
?
-
-
glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression
-
-
?
additional information
?
-
-
role of a bound glucokinase protein fraction in the regulation of insulin granule movement along tubulin filaments
-
-
?
additional information
?
-
no activity with D-xylose, D-galactose, and methyl-alpha-D-glucoside
-
-
?
additional information
?
-
-
no activity with D-xylose, D-galactose, and methyl-alpha-D-glucoside
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
not: N-acetyl-D-glucosamine
-
-
?
additional information
?
-
-
not: N-acetyl-D-glucosamine
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
-
OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
-
OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
-
OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
-
-
?
additional information
?
-
-
OsHXK8 may function in the endosperm in the filling phase of rice seed development
-
-
?
additional information
?
-
OsHXK8 may function in the endosperm in the filling phase of rice seed development
-
-
?
additional information
?
-
OsHXK8 may function in the endosperm in the filling phase of rice seed development
-
-
?
additional information
?
-
OsHXK8 may function in the endosperm in the filling phase of rice seed development
-
-
?
additional information
?
-
OsHXK8 may function in the endosperm in the filling phase of rice seed development
-
-
?
additional information
?
-
OsHXK8 may function in the endosperm in the filling phase of rice seed development
-
-
?
additional information
?
-
-
ligand binding sites in the N- and C-terminal halves and interactions between these sites
-
-
?
additional information
?
-
structure model of hexokinase I
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
allosteric regulation of hexokinase I, the functional regulatory glucose 6-phosphate binding site is located in the N-terminal half
-
-
?
additional information
?
-
-
isolated catalytically active 51 kDa C-fragment and 52 kDa N-fragment without catalytic activity, both fragments contain discrete binding sites for hexoses and hexose 6-phosphates, one of each pair of sites must be latent in the intact enzyme, the regulatory site binding glucose 6-phosphate is associated with the N-terminal half
-
-
?
additional information
?
-
-
not: trehalose
-
-
?
additional information
?
-
hexokinase I and hexokinase II are independently regulated, implying that they perform different roles in cardiac glucose regulation
-
-
?
additional information
?
-
hexokinase I and hexokinase II are independently regulated, implying that they perform different roles in cardiac glucose regulation
-
-
?
additional information
?
-
-
the enzyme plays a role in glycogen synthesis and glucose homeostasis
-
-
?
additional information
?
-
-
glucokinase: not: fructose, galactose, sorbose, rhamnose, arabinose, mannitol, sorbitol, ribose
-
-
?
additional information
?
-
-
not: N-acetylmannosamine, 6-deoxy-6-aminoglucose
-
-
?
additional information
?
-
-
allosteric enzyme, catalyzes phosphoryl transfer from MgATP2- to the 6-OH group of a number of furanose- and pyranose-type compounds
-
-
?
additional information
?
-
-
hexokinase PI is a constitutive enzyme, hexokinase PII and glucokinase are regulated by the carbon source used
-
-
?
additional information
?
-
-
relatively nonspecific enzyme
-
-
?
additional information
?
-
G/F discrepancy in Saccharomyces cerevisiae is not related to the maximal hexokinase activity in vitro with glucose or fructose as substrate or to the ratio between the Km values for glucose and fructose phosphorylation but might rather be related to the actual fructose phosphorylating activity at physiological fructose levels in vivo
-
-
?
additional information
?
-
-
G/F discrepancy in Saccharomyces cerevisiae is not related to the maximal hexokinase activity in vitro with glucose or fructose as substrate or to the ratio between the Km values for glucose and fructose phosphorylation but might rather be related to the actual fructose phosphorylating activity at physiological fructose levels in vivo
-
-
?
additional information
?
-
-
glucokinase: not: fructose, galactose, sorbose, rhamnose, arabinose, mannitol, sorbitol, ribose
-
-
?
additional information
?
-
-
hexokinase PI is a constitutive enzyme, hexokinase PII and glucokinase are regulated by the carbon source used
-
-
?
additional information
?
-
galactose is phosphorylated at rates of 0.8 and 0.08 U/mg at concentrations of 1 and 10 mM, respectively. Ribose, xylose, N-acetylmannosamine, glucose-1-phosphate, and fructose-6-phosphate (10 mM) are not phosphorylated by the enzyme
-
-
?
additional information
?
-
-
galactose is phosphorylated at rates of 0.8 and 0.08 U/mg at concentrations of 1 and 10 mM, respectively. Ribose, xylose, N-acetylmannosamine, glucose-1-phosphate, and fructose-6-phosphate (10 mM) are not phosphorylated by the enzyme
-
-
?
additional information
?
-
galactose is phosphorylated at rates of 0.8 and 0.08 U/mg at concentrations of 1 and 10 mM, respectively. Ribose, xylose, N-acetylmannosamine, glucose-1-phosphate, and fructose-6-phosphate (10 mM) are not phosphorylated by the enzyme
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
not: ADP
-
-
?
additional information
?
-
-
not: ADP
-
-
?
additional information
?
-
not: ribose, xylose, phosphorylated hexoses, UDP, polyphosphates
-
-
?
additional information
?
-
-
not: ribose, xylose, phosphorylated hexoses, UDP, polyphosphates
-
-
?
additional information
?
-
not: D-galactose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
not: CTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
no activity with D-galactose and N-acetylglucosamine, enzyme shows broad substrate specificity, specificity probably depends on the interaction energy occurring by the positional proximity of sugars bound in the active site
-
-
?
additional information
?
-
no activity with D-galactose and N-acetylglucosamine, enzyme shows broad substrate specificity, specificity probably depends on the interaction energy occurring by the positional proximity of sugars bound in the active site
-
-
?
additional information
?
-
-
no activity with D-galactose and N-acetylglucosamine, enzyme shows broad substrate specificity, specificity probably depends on the interaction energy occurring by the positional proximity of sugars bound in the active site
-
-
?
additional information
?
-
the enzyme shows little catalytic capacity for galactose and fructose
-
-
?
additional information
?
-
-
the enzyme shows little catalytic capacity for galactose and fructose
-
-
?
additional information
?
-
the enzyme shows little catalytic capacity for galactose and fructose
-
-
?
additional information
?
-
not: ADP
-
-
?
additional information
?
-
-
not: ADP
-
-
?
additional information
?
-
not: UTP
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
not: diphosphate
-
-
?
additional information
?
-
-
not: diphosphate
-
-
?
additional information
?
-
not: D-galactose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?
additional information
?
-
not: ITP
-
-
?
additional information
?
-
-
not: ITP
-
-
?
additional information
?
-
not: GTP
-
-
?
additional information
?
-
-
not: GTP
-
-
?
additional information
?
-
not: CTP
-
-
?
additional information
?
-
-
not: CTP
-
-
?
additional information
?
-
not: ADP
-
-
?
additional information
?
-
not: UTP
-
-
?
additional information
?
-
not: diphosphate
-
-
?
additional information
?
-
not: D-galactose
-
-
?
additional information
?
-
not: ITP
-
-
?
additional information
?
-
the C-terminal tail of TbHK1 is important for hexokinase activity
-
-
?
additional information
?
-
-
the C-terminal tail of TbHK1 is important for hexokinase activity
-
-
?
additional information
?
-
not: diphosphate
-
-
?
additional information
?
-
-
not: diphosphate
-
-
?
additional information
?
-
not: mannose
-
-
?
additional information
?
-
-
not: mannose
-
-
?
additional information
?
-
not: fructose
-
-
?
additional information
?
-
-
not: fructose
-
-
?
additional information
?
-
not: D-galactose
-
-
?
additional information
?
-
-
not: D-galactose
-
-
?