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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
bifunctional 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 mRNA expression is greater in metastatic prostate cancer compared with primary tumors
blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2
blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2. Hypoxic conditions leads to an increase of the expression level of PFKFB3 and PFKFB4 mRNA both in control glioma cells and cells with ERN1 loss of function, being more significant for PFKFB4. The blockade of ERN1 signaling enzyme function decreases the effect of hypoxia on the expression level of both PFKFB3 and PFKFB4 mRN
ectopic expression of wild type PFKFB3 increases phosphorylation of the cell cycle inhibitor p27, a member of the Kip/Cip family of proteins and a universal inhibitor of cyclin-dependent kinases and the cell cycle, at threonine 187 and decreases total p27 protein levels
re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons
re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons
re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons