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2.7.1.105: 6-phosphofructo-2-kinase

This is an abbreviated version!
For detailed information about 6-phosphofructo-2-kinase, go to the full flat file.

Word Map on EC 2.7.1.105

Reaction

ATP
+
beta-D-fructose 6-phosphate
=
ADP
+
beta-D-fructose 2,6-bisphosphate

Synonyms

6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2, 6-phosphofructo kinase-2/fructose diphosphatase-2 isoenzyme 3, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex, 6-phosphofructose 2-kinase, 6PF2K/Fru-2,6-P2ase, ATP:D-fructose-6-phosphate 2-phosphotransferase, fructose 6-phosphate 2-kinase, inducible 6-phosphofructo-2-kinase, iPFK2, kinase, 6-phosphofructo-2-(phosphorylating), OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK2, PFK2/FBPase2, PFKFB, PFKFB-3, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphofructokinase 2, phosphofructokinase-2, phosphofructokinase-2/fructose bisphosphatase-2, T-PFK2, tPFK-2, uPFK-2

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.105 6-phosphofructo-2-kinase

Expression

Expression on EC 2.7.1.105 - 6-phosphofructo-2-kinase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
bifunctional 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 mRNA expression is greater in metastatic prostate cancer compared with primary tumors
blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2
blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2. Hypoxic conditions leads to an increase of the expression level of PFKFB3 and PFKFB4 mRNA both in control glioma cells and cells with ERN1 loss of function, being more significant for PFKFB4. The blockade of ERN1 signaling enzyme function decreases the effect of hypoxia on the expression level of both PFKFB3 and PFKFB4 mRN
ectopic expression of wild type PFKFB3 increases phosphorylation of the cell cycle inhibitor p27, a member of the Kip/Cip family of proteins and a universal inhibitor of cyclin-dependent kinases and the cell cycle, at threonine 187 and decreases total p27 protein levels
enzyme expression in esophageal squamous cell carcinoma cell is significantly higher than in adjacent non-tumor tissues
ERN1 loss of function and hypoxic conditions do not affect PFKFB1 mRNA levels
hypoxic conditions do not affect PFKFB2 mRNA levels
in cells with ERN1 loss of function decreases PFKFB2 mRNA
isozyme PFKFB3 variant I-PFK2 is inducible
isozyme PFKFB4 is induced by hypoxia
maximum expression of Pfkfb3 in cells before puberty, maximum expression of Pfkfb4 in adult cells
-
p53 downregulates PFKFB4 expression by binding to its promoter and mediating transcriptional repression via histone deacetylases
PFKFB3 is the major 6-phosphofructo-2-kinase isozymes overexpressed in human cancers
PFKFB4 is the major 6-phosphofructo-2-kinase isozymes overexpressed in human cancers
re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons
the PFK2 expression is increased about 2fold in 0.5 mM ammonia treated brain slices
-
upon re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami