2.7.1.108: dolichol kinase
This is an abbreviated version!
For detailed information about dolichol kinase, go to the full flat file.
Word Map on EC 2.7.1.108
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2.7.1.108
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dolichyl
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n-glycosylation
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ctp-dependent
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polyprenols
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cis-prenyltransferase
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dolichol-linked
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mannosylated
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o-mannosylation
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polyisoprenoids
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pyrophosphorylated
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alpha-isoprene
- 2.7.1.108
- dolichyl
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n-glycosylation
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ctp-dependent
- polyprenols
- cis-prenyltransferase
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dolichol-linked
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mannosylated
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o-mannosylation
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polyisoprenoids
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pyrophosphorylated
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alpha-isoprene
Reaction
Synonyms
At3g45040, AtDOK1, cytidine-5-triphosphate (CTP) dependent dolichol kinase, DK, DK1, DOK1, dolichol kinase, dolichol kinase 1, dolichol phosphokinase, dolichol-specific kinase, DOLK, SEC59, Sec59p
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Natural Substrates Products on EC 2.7.1.108 - dolichol kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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the chain length of eukaryotic dolichol molecules is species specific and differs from 14-17 isoprene units in unicellular organisms like the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, mammalian cells produce longer dolichol molecules with 18-21 isoprene units
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CTP + dolichol
CDP + dolichyl phosphate
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newly formed dolichyl monophosphate, phosphorylated via CTP is available for biosynthesis of mannosylphosphoryldolichol and N-acetylglucosaminylpyrophosphoryldolichol
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?
CTP + dolichol
CDP + dolichyl phosphate
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CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo
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?
CTP + dolichol
CDP + dolichyl phosphate
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DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate
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?
CTP + dolichol
CDP + dolichyl phosphate
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DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate, defect in human DK1 affects the biosynthesis of dolichol phosphate by the disturbance of the final phosphorylation step, causes lethal phenotype with death in early infancy.
dolichyl phosphate is involved in several glycosylation reactions, such as N-glycosylation, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, and C- and O-mannosylation
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?
CTP + dolichol
CDP + dolichyl phosphate
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enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules
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?
CTP + dolichol
CDP + dolichyl phosphate
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enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules
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?
CTP + dolichol
CDP + dolichyl phosphate
CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo
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?
