Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.11: 6-phosphofructokinase

This is an abbreviated version!
For detailed information about 6-phosphofructokinase, go to the full flat file.

Word Map on EC 2.7.1.11

Reaction

ATP
+
beta-D-fructofuranose 6-phosphate
=
ADP
 +
beta-D-fructofuranose 1,6-bisphosphate

Synonyms

1-phosphofructokinase, 2-keto-3-deoxygluconate kinase, 6-phosphofructo 1-kinase, 6-phosphofructo-1-kinase, 6-phosphofructokinase I, 6-phosphofructokinase, platelet type, 6-phosphofructose 1-kinase, 6-phosphofructose-1-kinase, A/GTP-PFK, ADP-dependent phosphofructokinase, APE0012, At2g22480, At4g26270, At4g29220, At4g32840, At5g56630, At5g61580, ATP-dependent 6-phosphofructokinase, ATP-dependent 6-phosphofructokinase isozyme 2, ATP-dependent PFK, ATP-dependent phosphofructokinase, ATP-PFK, ATP: D-fructose-6-phosphate-1-phosphotransferase, ATP:D-fructose-6-phosphate-1-phosphotransferase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, fructose 6-phosphokinase, hosphofructokinase-1, HVO_A0328, KDG kinase, KDGal kinase, KDGK-1, KDGK-2, kinase, phosphofructo- (phosphorylating), LmPFK, muscle-type phosphofructokinase, nucleotide triphosphate-dependent phosphofructokinase, OC_Os04g39420, PFK, PFK-1, Pfk-2, PFK-L, PFK-M, PFK-P, PFK1, PFK2, PFK3, PFK4, PFK5, PFK6, PFK7, PFKA, PFKA1, PFKA2, PFKA3, pfkB, PFKL, PFKM, PFKMS, PFKP, PfpA4, phospho-1,6-fructokinase, phosphofructo-1-kinase, phosphofructokinase, phosphofructokinase 1, phosphofructokinase M, phosphofructokinase-1, phosphofructokinase-2, phosphofructokinase-M, phosphofructokinase-P, phosphohexokinase, TbPFK, TcPFK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.11 6-phosphofructokinase

Activating Compound

Activating Compound on EC 2.7.1.11 - 6-phosphofructokinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
activates
Aldolase
-
about 120% activity in the presence of 0.005 mM aldolase
-
Calmodulin
cAMP-dependent protein kinase
-
citrate
Cl-
-
200 mM, 3.1fold activation of cytosolic PFK
D-fructose 1,6-bisphosphate
D-fructose 2,6-bisphosphate
D-fructose-1,6-bisphosphate
-
activates synergistically with AMP and ADP
D-Glucose 1,6-bisphosphate
D-glucose 6-phosphate
-
4.8 mM, 1.5fold increase in activity at 2 mM fructose 6-phosphate, 2fold increase at 4 mM fructose 6-phosphate, in vitro
Dimethylsulfoxide
-
20%, 9fold increase in activity, probably due to crowding effect
fructose 2,6-bisphosphate
-
at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects
fructose 6-phosphate
S0.5 value for wild-type 0.88 mM, in presence of 1 mM AMP S0.5 value 0.052 mM. S0.5 value for N-terminal truncation mutant 0.089 mM, in presence of 1 mM AMP S0.5 value 0.030 mM
glutathione
-
activation
glycerol
-
40%, 4fold increase in activity, probably due to crowding effect
HAsO42-
-
50 mM, 2.9fold activation of cytosolic PFK
HCO3-
-
200 mM, 2.1fold activation of cytosolic PFK
MgATP2-
the apparent Km for MgATP2- is 0.022 mM
NO3-
-
50 mM 1.6fold activation of cytosolic PFK
phosphate
phosphatidylserine
-
-
phosphoenol pyruvate
slightly enhances activity
Polyethylene glycol
-
20%, 8fold increase in activity, probably due to crowding effect
serotonin
-
stimulates 6-phosphofructo-1-kinase from skeletal muscle via phospholipase C. The activation of phospholipase C in skeletal muscle leads to the recruitment of protein kinase C PKC and calmodulin and the stimulation of calmodulin kinase II, which associates with 6-phosphofructo-1-kinase upon serotonin action
SO42-
Sodium acetate
-
about 115% activity in the presence of 0.04 mM sodium acetate
trehalose
-
activates
additional information
-