2.7.1.11: 6-phosphofructokinase
This is an abbreviated version!
For detailed information about 6-phosphofructokinase, go to the full flat file.
Word Map on EC 2.7.1.11
-
2.7.1.11
-
citrate
-
glycogen
-
amp
-
glucose-6-phosphate
-
2,6-bisphosphate
-
aldolase
-
phosphorylase
-
phosphoenolpyruvate
-
erythrocyte
-
pentose
-
glucokinase
-
gluconeogenesis
-
malate
-
creatine
-
hexose
-
glyceraldehyde-3-phosphate
-
phosphoglycerate
-
fructose-2,6-bisphosphate
-
enolase
-
fructose-1,6-bisphosphatase
-
gluconeogenic
-
vastus
-
carboxykinase
-
6-phosphogluconate
-
lateralis
-
6-phosphofructo-2-kinase
-
phosphoglucose
-
triose
-
phosphoglucomutase
-
pfkfb3
-
soleus
-
1,6-bisphosphatase
-
mgatp
-
phosphocreatine
-
fbpase
-
m-type
-
fructose-1,6-diphosphate
-
myoglobinuria
-
bisphosphatase
-
glycogenosis
-
2.7.1.1
-
1,6-diphosphate
-
liver-type
-
entner-doudoroff
-
2,3-diphosphoglycerate
-
3-hydroxyacyl-coa
-
mcardle
-
synthesis
-
heterotropic
-
biotechnology
-
analysis
-
glycogenolytic
-
myophosphorylase
-
medicine
- 2.7.1.11
- citrate
- glycogen
- amp
- glucose-6-phosphate
- 2,6-bisphosphate
- aldolase
- phosphorylase
- phosphoenolpyruvate
- erythrocyte
- pentose
- glucokinase
-
gluconeogenesis
- malate
- creatine
- hexose
- glyceraldehyde-3-phosphate
- phosphoglycerate
- fructose-2,6-bisphosphate
- enolase
- fructose-1,6-bisphosphatase
-
gluconeogenic
-
vastus
-
carboxykinase
- 6-phosphogluconate
- lateralis
- 6-phosphofructo-2-kinase
-
phosphoglucose
- triose
- phosphoglucomutase
- pfkfb3
- soleus
-
1,6-bisphosphatase
- mgatp
- phosphocreatine
- fbpase
-
m-type
- fructose-1,6-diphosphate
- myoglobinuria
-
bisphosphatase
- glycogenosis
-
2.7.1.1
- 1,6-diphosphate
-
liver-type
-
entner-doudoroff
- 2,3-diphosphoglycerate
- 3-hydroxyacyl-coa
- mcardle
- synthesis
-
heterotropic
- biotechnology
- analysis
-
glycogenolytic
- myophosphorylase
- medicine
Reaction
Synonyms
1-phosphofructokinase, 2-keto-3-deoxygluconate kinase, 6-phosphofructo 1-kinase, 6-phosphofructo-1-kinase, 6-phosphofructokinase I, 6-phosphofructokinase, platelet type, 6-phosphofructose 1-kinase, 6-phosphofructose-1-kinase, A/GTP-PFK, ADP-dependent phosphofructokinase, APE0012, At2g22480, At4g26270, At4g29220, At4g32840, At5g56630, At5g61580, ATP-dependent 6-phosphofructokinase, ATP-dependent 6-phosphofructokinase isozyme 2, ATP-dependent PFK, ATP-dependent phosphofructokinase, ATP-PFK, ATP: D-fructose-6-phosphate-1-phosphotransferase, ATP:D-fructose-6-phosphate-1-phosphotransferase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, fructose 6-phosphokinase, hosphofructokinase-1, HVO_A0328, KDG kinase, KDGal kinase, KDGK-1, KDGK-2, kinase, phosphofructo- (phosphorylating), LmPFK, muscle-type phosphofructokinase, nucleotide triphosphate-dependent phosphofructokinase, OC_Os04g39420, PFK, PFK-1, Pfk-2, PFK-L, PFK-M, PFK-P, PFK1, PFK2, PFK3, PFK4, PFK5, PFK6, PFK7, PFKA, PFKA1, PFKA2, PFKA3, pfkB, PFKL, PFKM, PFKMS, PFKP, PfpA4, phospho-1,6-fructokinase, phosphofructo-1-kinase, phosphofructokinase, phosphofructokinase 1, phosphofructokinase M, phosphofructokinase-1, phosphofructokinase-2, phosphofructokinase-M, phosphofructokinase-P, phosphohexokinase, TbPFK, TcPFK
ECTree
2.7.1.11 6-phosphofructokinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.11 - 6-phosphofructokinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-carboxymethyl-ATP + D-fructose 6-phosphate
1-carboxymethyl-ADP + D-fructose 1,6-bisphosphate
90% of activity with with ATP
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
ADP + D-fructose 6-phosphate
AMP + D-fructose 1,6-bisphosphate
-
-
-
r
AMP + D-fructose 1,6-bisphosphate
ADP + D-fructose 6-phosphate
-
-
-
r
ATP + 2-dehydro-3-deoxy-D-gluconate
ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
-
-
-
?
ATP + D-tagatose 6-phosphate
ADP + ?
-
poor substrate for isoenzyme PFK2
-
-
?
ATP + glucose 6-phosphate
ADP + glucose 1,6-bisphosphate
-
-
?
gamma-thio-ATP + fructose 6-phosphate
ADP + fructose 1-thio-phosphate-6-phosphate
3000fold lower kcat than with ATP
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
-
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
-
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
-
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
-
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
-
-
?
ADP + D-fructose 1,6-bisphosphate
ATP + D-fructose 6-phosphate
for human cells, the measured K0.5(ADP)0:5 values for the reaction with ADP and D-fructose 1,6-bisphosphate exceeds the cytosolic concentrations of ADP, but as steady-state concentrations of F0.5(D-fructose 1,6-bisphosphate) are lower than the K0.5(D-fructose 1,6-bisphosphate) values, it seems likely that under steady-state conditions the reverse reaction would indeed be inefficient. However, cells can be subjected to extreme conditions of stress and nutrient deprivation and the phosphofructokinase reverse flux may be very different in non-steady state, glucose-poor conditions and Q values of 500 or above can easily be achieved if ATP or glucose-6-phosphate are (transiently) depleted
-
-
r
ADP + D-fructose 1,6-bisphosphate
ATP + D-fructose 6-phosphate
-
-
-
r
ADP + D-fructose 1,6-bisphosphate
ATP + D-fructose 6-phosphate
-
-
-
r
ADP + D-fructose 1,6-bisphosphate
ATP + D-fructose 6-phosphate
-
-
-
r
ADP + D-fructose 1,6-bisphosphate
ATP + D-fructose 6-phosphate
-
-
-
r
ADP + D-fructose 1,6-bisphosphate
ATP + D-fructose 6-phosphate
-
-
-
r
ATP + D-fructose 1-phosphate
ADP + D-fructose 1,6-bisphosphate
-
key enzyme of glucose metabolism
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
absolutely specific for fructose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
the enzyme is involved in the ribulose monophosphate cycle
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
the enzyme is involved in the ribulose monophosphate cycle
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
the enzyme is involved in the ribulose monophosphate cycle
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
F1Q3S9, P52784
key regulatory enzyme of glycolysis
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
fructose 6-phosphate shows negative cooperativity at low concentrations and positive cooperativity at high concentrations
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
no activity with diphosphate as phosphate donor
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
reversible reaction in vivo, but not in vivo, very low activity with acetyl phosphate, UDP and GDP as phosphoryl donors, enzyme is not regulated allosterically
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
Dunaliella marina
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
no activity with glucose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
best phosphoryl donors and acceptors of PFK1 and PFK2
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
no activity with hexitol 6-phosphates
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
first step in glycolysis
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
first step in glycolysis
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
two types of phosphofructokinase-1 (PFK-L and PFK-M) differentially regulate the glycolytic pathway in insulin-stimulated chicken skeletal muscle
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
35fold lower reverse reaction velocity
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
key glycolytic enzyme
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
the enzyme catalyzes a rate-limiting reaction in glycolysis
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
the enzyme is involved in glycolysis
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
all three human PFK isoforms can catalyse the reverse reaction in vitro
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
no cooperativity with respect to fructose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
fructose 6-phosphate shows cooperativity
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
50% reduction of PFK expression leads to a proportionally decrease of growth rate, glycolytic flux and lactate flux
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
sigmoid response to fructose 6-phosphate concentration
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
importance of phosphofructokinase-M for insulin secretion
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
phosphofructokinase-1 is an important control point in the glycolytic pathway, it is implicated in the functions of astrocytes and neurons
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
no activity with glucose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
transfers gamma-phosphate of ATP to C-1-hydroxyl of D-(-)fructose 6-phosphate, highly specific for sugar substrate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
glycolytic enzyme
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
the enzyme shows an extremely high degree of cooperative binding, resulting in a virtual on/off switch for substrate concentrations near its K1/2 value
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
important control point for glycolytic flux in the pathway from glucose to fatty acid in the lactating mammary gland, PFK is reactivated by re-feeding of starved animals
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
reducing fructose 6-phosphate concentration results in dissociation and inactivation
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
high cooperativity with respect to fructose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
dominant rate-controlling enzyme of glucose degradation via Embden-Meyerhof pathway, involved in generation of glycolytic oscillations
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
the enzyme shows cooperative binding for fructose-6-phosphate and non-cooperative binding for ATP. Pfk1 undergoes a large conformational change upon Mg-ATP binding
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
sigmoidal kinetics with fructose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
sigmoidal kinetics with fructose 6-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
first step in glycolysis
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
first step in glycolysis
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
allosteric enzyme, involved in regulation of glycolytic flux
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
allosteric enzyme, involved in regulation of glycolytic flux
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
first step in glycolysis
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
first step in glycolysis
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
the enzyme shows strictly high specificity for its phosphoryl donor. ADP, AMP, GDP, and PPi could not substitute for ATP
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
the enzyme shows strictly high specificity for its phosphoryl donor. ADP, AMP, GDP, and PPi could not substitute for ATP
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
engineering to increase antibiotic production
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
improved antibiotic production by deletion of PFKA2, involvement of PFKA2 in determining the carbon flux distribution
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
20% phosphofructokinase activity is observed in the presence of 2 mM ATP compared to 100% in the presence of equimolar ADP
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
specific for fructose 6-phosphate, very low activity with UTP and CTP
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
reversible reaction in vitro
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
transfers gamma-phosphate of ATP to C-1-hydroxyl of D-(-)fructose 6-phosphate, highly specific for sugar substrate
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
negative and positive cooperative kinetics at low fructose 6-phosphate concentrations
-
?
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
-
-
r
ATP + D-fructose 6-phosphate
ADP + D-fructose 1,6-bisphosphate
-
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
-
?
ATP + fructose 1-phosphate
ADP + fructose 1,6-bisphosphate
60fold lower kcat than with fructose 6-phosphate
-
?
ATP + fructose 1-phosphate
ADP + fructose 1,6-bisphosphate
-
5% of activity with D-fructose 6-phosphate
-
?
ATP + sedoheptulose 7-phosphate
ADP + sedoheptulose 1,7-bisphosphate
-
-
-
?
ATP + sedoheptulose 7-phosphate
ADP + sedoheptulose 1,7-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
20.6% of the activity with ATP
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
20.6% of the activity with ATP
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
55% of activity with ATP
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
less effective than ATP
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
ITP, GTP or UTP as phosphoryl donors
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
as effective as ATP
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 28% the rate of ATP
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 28% the rate of ATP
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
less effective than ATP
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
-
-
?
CTP + D-fructose 6-phosphate
CDP + D-fructose 1,6-bisphosphate
-
13% of activity with ATP
-
?
dATP + D-fructose 6-phosphate
dADP + D-fructose 1,6-bisphosphate
-
-
-
?
dATP + D-fructose 6-phosphate
dADP + D-fructose 1,6-bisphosphate
-
as good as ATP
-
?
dATP + D-fructose 6-phosphate
dADP + D-fructose 1,6-bisphosphate
-
as good as ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
76% of activity with ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
84.1% of the activity with ATP
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
84.1% of the activity with ATP
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
100% of activity with ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
less effective than ATP or ITP, better than UTP or CTP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
almost as effective as ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 35% the rate of ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 35% the rate of ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
almost as effective as ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
-
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
42% of activity with ATP
-
?
GTP + D-fructose 6-phosphate
GDP + D-fructose 1,6-bisphosphate
-
64% of activity of ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
76% of activity with ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
130% of activity with ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
less effective than ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
better than GTP, UTP or CTP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 71% the rate of ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 71% the rate of ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
less effective than ATP
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
-
-
?
ITP + D-fructose 6-phosphate
IDP + D-fructose 1,6-bisphosphate
-
38% of activity with ATP
-
?
TTP + D-fructose 6-phosphate
TDP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
?
TTP + D-fructose 6-phosphate
TDP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
?
TTP + D-fructose 6-phosphate
TDP + D-fructose 1,6-bisphosphate
-
10% of activity with ATP
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
40% of activity with ATP
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
purine NTPs preferred
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
less effective than ATP, ITP, GTP, better than CTP
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
as effective as ATP
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 16% the rate of ATP
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
phosphorylation at 16% the rate of ATP
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
-
-
?
UTP + D-fructose 6-phosphate
UDP + D-fructose 1,6-bisphosphate
-
14% of activity with ATP
-
?
additional information
?
-
-
the enzyme does also use 2-dehydro-3-deoxy-D-galactonate as substrate
-
-
?
additional information
?
-
the enzyme does also use 2-dehydro-3-deoxy-D-galactonate as substrate
-
-
?
additional information
?
-
-
insulin may increase the glucose consumption in human erythrocytes, through a mechanism involving Ca2+ influx, calmodulin and the detachment of 6-phosphofructose-1-kinase from the erythrocyte membrane
-
-
?
additional information
?
-
-
structure of the ATP-bound state of phosphofructokinase determined by cryo-electron microscopy
-
-
?
additional information
?
-
-
6-phosphofructokinase is the most important element for control of glycolytic flux
-
-
?
