2.7.1.127: inositol-trisphosphate 3-kinase

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For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.127

2.7.1.127

1,3,4,5-tetrakisphosphate

kawasaki

vasculitis

5-phosphatase

tetrakisphosphate

diagnostics

medicine

Reaction

1D-myo-inositol 1,3,4,5-tetrakisphosphate

Synonyms

1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.127 inositol-trisphosphate 3-kinase

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Results	in table
55	Activating Compound
24	AA Sequence
2	Application
1	CAS Registry Number
51	Cloned(Commentary)
130	Cofactor
3	Crystallization (Commentary)
330	Disease/ Diagnostics
8	Expression
78	General Information
13	General Stability
69	IC50 Value
135	Inhibitors
16	Ki Value [mM]
45	KM Value [mM]
88	Localization
142	Metals/Ions
40	Molecular Weight [Da]
95	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
324	Organism
5	Pathway
6	PDB ID
40	pH Optimum
6	pH Range
1	pH Stability
16	Posttranslational Modification
29	Protein Variants
44	Purification (Commentary)
4	Reaction
7	Reaction Type
102	Reference
257	Source Tissue
36	Specific Activity [micromol/min/mg]
8	Storage Stability
152	Substrates and Products (Substrate)
38	Subunits
184	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]

KI Value

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KI Value on EC 2.7.1.127 - inositol-trisphosphate 3-kinase

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0.000096 - 0.0001

aurintricarboxylic acid

2 entries

0.000043 - 0.00006

ellagic acid

2 entries

0.00002 - 0.000043

epicatechin-3-gallate

2 entries

0.000059

epigallocatechin-3-gallate

2 entries

0.000061 - 0.000077

gossypol

2 entries

0.000074 - 0.000156

hypericin

2 entries

0.12

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide

Rattus norvegicus

640739

0.000197 - 0.000312

quercetin

2 entries

additional information

Gallus gallus

dose-response curve of antiproliferative synthetic and plant polyphenolics inhibition

662346