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2.7.1.127: inositol-trisphosphate 3-kinase

This is an abbreviated version!
For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.127

Reaction

ATP
+
1D-myo-inositol 1,4,5-trisphosphate
=
ADP
+
1D-myo-inositol 1,3,4,5-tetrakisphosphate

Synonyms

1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.127 inositol-trisphosphate 3-kinase

Specific Activity

Specific Activity on EC 2.7.1.127 - inositol-trisphosphate 3-kinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00029
-
-
0.00044
-
mouse brain second particulate fraction
0.00072
-
in absence of calmodulin
0.0008
-
liver
0.002
-
brain cortex
0.0026
-
recombinant enzyme in the first particulate fraction of transfected COS-7 cells
0.0048
-
37°C, isoenzyme A, rat cortical slices
0.0244
-
pH 7.2, 37°C
0.283
-
pH 7.4, 37°C
0.75 - 1.45
-
pH 7.4, 37°C, platelet, in presence of free Ca2+ and calmodulin
1.4
-
isoform B, in absence of the Ca2+/calmodulin complex
1.7
-
pH 7.4, 37°C, purified recombinant isoenzyme A overexpressed in CHO cells
1.94
-
pH 7.2, 37°C
10 - 20
-
pH 7.5, 37°C
14
-
purified recombinant K268E catalytic/CaM binding domain
15.77
-
pH 7.5, 37°C, recombinant isoform B
20
-
recombinant IP3K overexpressed in Escherichia coli, in absence of calmodulin
28.9
-
pH 7.5, 37°C, in absence of calmodulin
3.5
-
30°C, fully activated enzyme in presence of Ca2+/calmodulin
3.68
-
pH 7.5, 37°C
36.32
-
pH 7.5, 37°C, recombinant isoform A
60
-
pH 7.5, 37°C, in presence of calmodulin
additional information