2.7.1.137: phosphatidylinositol 3-kinase
This is an abbreviated version!
For detailed information about phosphatidylinositol 3-kinase, go to the full flat file.
Word Map on EC 2.7.1.137
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2.7.1.137
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wortmannin
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mapks
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mtor
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rapamycin
-
erk
-
endothelial
-
pten
-
signal-regulated
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pkc
-
metastasis
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bcl-2
-
sirna
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caspase-3
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agonist
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glycogen
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leukemia
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actin
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pik3ca
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phospholipase
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insulin-like
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mitogen
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cyclins
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integrins
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tumorigenesis
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irs-1
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tensin
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tnf
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neuroprotective
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c-jun
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pi3-kinase
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dominant-negative
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adipocytes
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nf-kappab
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anti-apoptotic
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insulin-stimulated
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gtpases
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insulin-induced
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akt1
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transwell
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platelet-derived
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rac1
-
kinase-3
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igf-i
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sh2
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substrate-1
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pleckstrin
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grb2
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egf-induced
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everolimus
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tyrosine-phosphorylated
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drug development
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medicine
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pharmacology
- 2.7.1.137
- wortmannin
- mapks
- mtor
- rapamycin
- erk
- endothelial
- pten
-
signal-regulated
- pkc
- metastasis
- bcl-2
- sirna
- caspase-3
- agonist
- glycogen
- leukemia
- actin
- pik3ca
- phospholipase
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insulin-like
-
mitogen
- cyclins
- integrins
- tumorigenesis
- irs-1
-
tensin
- tnf
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neuroprotective
- c-jun
- pi3-kinase
-
dominant-negative
- adipocytes
- nf-kappab
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anti-apoptotic
-
insulin-stimulated
- gtpases
-
insulin-induced
- akt1
-
transwell
-
platelet-derived
- rac1
- kinase-3
- igf-i
- sh2
- substrate-1
-
pleckstrin
- grb2
-
egf-induced
-
everolimus
-
tyrosine-phosphorylated
- drug development
- medicine
- pharmacology
Reaction
Synonyms
class 3 phosphatidylinositol 3-kinase vacuolar protein sorting 34, class I phosphoinositide 3-kinase, class III phosphatidylinositol 3-kinase, class III phosphoinositide 3-kinase, class III PI3K, HsC2-PI3K, hVps34, hVps34 PI 3-kinase, kinase (phosphorylating), phosphatidylinositol 3-, kinase, phosphatidylinositol 3- (phosphorylating), lipid kinase Vps34, mammalian vacuolar protein sorting 34 homologue, More, p110a, p110delta I PI3K., p110g-related PI 3-kinase, p85/p110 phosphoinositide 3-kinase, p85/p110 type phosphatidylinositol kinase, p85a phosphoinositide 3-kinase, phosphatidyl-inositol-3-kinase, phosphatidylinositide 3-kinase, phosphatidylinositide 3-kinase C2alpha, phosphatidylinositol 3 kinase, phosphatidylinositol 3'-kinase, phosphatidylinositol 3-kinase, phosphoinositide 3'-kinase, phosphoinositide 3-kinase, phosphoinositide 3-kinase Dp110, phosphoinositide 3-kinase gamma, phosphoinositide-3-kinase, PI 3-K, PI 3-kinase, PI-3-K, PI-3K, PI3 K, PI3 kinase, PI3-K, PI3-K-related protein MEC1, PI3-kinase, PI3K, PI3K type III, PI3Kalpha, PI3Kbeta, PI3Kgamma, PI3K_59F, PI3K_68D, PIK3, PIK3C3, protein sorting mutant 34 protein, PtdIns 3'-kinase, PtdIns 3-kinase, PtdIns 3-kinase vacuolar protein sorting 34, receptor-linked phosphatidylinositol 3-kinase, Rickettsia intracellular secreted kinase-1, Risk1, RT0135, TcVps34, type III phosphatidylinositol 3-kinase, vacuolar protein sorting 34, VPS34, Vps34p
ECTree
2.7.1.137 phosphatidylinositol 3-kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.137 - phosphatidylinositol 3-kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network
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-
?
ATP + Akt1
ADP + Akt1 phosphate
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phosphorylation at Ser473, a step in PI3K/Akt signaling
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-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
phosphatidylinositol-4,5-bisphosphate + ATP
?
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involved in signalling pathways leading to mitosis and differentiation
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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-
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
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class I enzyme, preferred substrate in vivo, physiologic regulation and mode of action
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?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
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class I enzyme, preferred substrate in vivo
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?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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class Ia isozyme
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
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synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility
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?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
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?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
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?
additional information
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PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo
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additional information
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enzyme plays an important role in the signalling of cell growth
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additional information
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enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
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additional information
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PI 3-kinase activity is a necessary step in the regulation of bone resorption
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additional information
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enzyme plays an important role in the signaling of cell growth
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additional information
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receptor linked enzyme may generate a second-messenger signal
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additional information
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regulating longevity and diapause
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additional information
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
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?
additional information
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enzyme is involved in formyl peptide-induced stimulation of neutrophils
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?
additional information
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the level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase
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additional information
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role for Dp110 in growth control during Drosophila development
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additional information
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PI 3-kinase activity is a necessary step in the regulation of bone resorption
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?
additional information
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enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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?
additional information
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enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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additional information
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enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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?
additional information
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PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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?
additional information
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PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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?
additional information
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PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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?
additional information
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TAPP1 and TAPP2 are direct targets of PI3K signaling
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?
additional information
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activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity, activation is dependent on the phosphorylation event of p85
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?
additional information
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the enzyme is implicated in the control of breast cancer cell growth by free fatty acids and may provide a link between fat and cancer
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?
additional information
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important functional role of phosphatidylinositol 3-kinase in motile responses of HL-60 cells
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?
additional information
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monocytes respond to LPS with the rapid activation of PI 3-kinase, resulting in transient increases in levels of PtdIns 3,4,5-P3. This process is CD14 dependent and involves the physiological association of PI 3-kinase with activated p53/56lyn
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?
additional information
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role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein-coupled receptor systems in human neutrophils
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?
additional information
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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?
additional information
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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?
additional information
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IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase
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additional information
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plays a central part in the mediation of insulin-stimulated glucose disposal
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?
additional information
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activation of PI3K is a critical component of the anti-Ig-initiated signaling cascade that leads to growth inhibition of human B lymphoma cells
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?
additional information
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myotubularin, a phosphatase deficient in myotubular myopathy, may decrease PI3P levels by down-regulating PI3K activity and by directly degrading PI3P
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?
additional information
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mitogenic signal transduction pathway mediated by P13K is dependent upon the enzymatic activity of the p110 alpha subunit of P13K
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?
additional information
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enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes
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?
additional information
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class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity
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?
additional information
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enzyme is involved in the signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli
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?
additional information
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the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, the enzyme is involved in many cellular responses important in pathogenesis of disease
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?
additional information
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the enzyme is involved in cytokin-stimulated cell migration
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?
additional information
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interaction between Beclin and hVps34 PI 3-kinase is essential for engagement of hVps34 in the process of macroautophagy, but is dispensable for the normal function of hVps34 in endocytic trafficking or lysosomal enzyme sorting
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?
additional information
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AMP-activated protein kinase, activated by energy depletion, inhibits cell survival by binding to and phosphorylating insulin receptor substrate-1 at Ser-794. Phosphorylation of insulin receptor substrate-1 at this site inhibits phosphatidylinositol 3-kinase/Akt signaling, suppresses the mitochondrial membrane potential, and promotes apoptosis
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?
additional information
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anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway
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additional information
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Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism
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additional information
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IGF-I regulates the expression of FLIP in FRTL cells by activating the PI3K/NF-kB cascade
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additional information
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IL-2-induced PI3K activation limits IL-17RA gene expression. Blockade of the PI3K pathway but not p70S6K leads to up-regulation of IL-17RA
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additional information
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mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism
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?
additional information
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PI 3-kinase signaling in proliferating cells regulates a novel program of gene expression, which is distinct from that induced by growth factor stimulation of quiescent cells. The expression program controlled by continuous PI 3-kinase signaling in proliferating cells is enriched in genes that regulate cell survival and is mediated in large part by FOXO and RelB transcription factors
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?
additional information
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the phosphatidylinositol 3-kinase/Akt signaling pathway is required for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
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?
additional information
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class III PI3K Vps34p is associated with Vsp15
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?
additional information
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effects of the specific PI3K inhibitor LY294002 on Kv1.5 channels, wild-type and mutant, are independent of the effects on PI3K activity, overview
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additional information
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PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, peptide N24. This interaction is critical for cell proliferation and cell cycle progression
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?
additional information
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
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?
additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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?
additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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?
additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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?
additional information
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class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity
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?
additional information
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the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, e.g. in cell survival, vesicle trafficking, cytoskeletal reorganization, and chemotaxis, the enzymeis involved in diverse signalling pathways, detailed schematic overview
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additional information
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PI-3-kinase might be involved in the induction of erythroid differentiation, possibly engaging a protein kinase C z as downstream effector
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additional information
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the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters
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additional information
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may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
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may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system
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?
additional information
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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?
additional information
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
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phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
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additional information
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insulin stimulation of fatty acid synthase promoter is mediated by the PI 3-kinase pathway
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additional information
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enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
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?
additional information
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differential regulation of insulin receptor substrate-1 and insulin receptor substrate-2 and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic mouse
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additional information
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insulin activates ATP-sensitive K+ channels in pancreatic B-cells through a phosphatidylinositol 3-kinase-dependent pathway
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additional information
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reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
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additional information
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enzyme could be involved in stimulated glucose transport in muscle
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additional information
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the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview
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additional information
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leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression
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additional information
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type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
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additional information
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lutein inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways
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additional information
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raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene
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additional information
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activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta
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additional information
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two populations of p27 use different kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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additional information
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two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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additional information
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isoform p110b of the catalytic subunit plays a crucial role in cellular activities evoked acutely by insulin
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additional information
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PI 3-kinase is the first step of the insulin signaling pathway to be impaired by high-fat feeding
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additional information
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essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
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additional information
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PI 3-K pathways is involved in the short-term activation of pyruvate kinase L by insulin in rat hepatocytes
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additional information
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insulin signaling in heart involves insulin receptor substrate-1 and insulin receptor substrate-2, activation of phosphatidylinositol 3-kinase
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additional information
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signaling pathways for phosphoinositolglycan-peptide and insulin to glucose transport and metabolism converge at the level of PI 3-kinase
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additional information
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PI 3-kinase activity appears to be an important component of ovariectomy-stimulated bone loss in rats
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additional information
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insulin and dexamethasone regulate phosphatidylinositol 3-kinase in Fao hepatoma cells
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additional information
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insulin-stimulated IRS-1 association with PI 3-kinase is decreased to 84% in the liver and to 84% in the muscle in the fructose-fed group compared to controls
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additional information
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in both the liver and muscle of high salt-fed rats, intracellular insulin signaling leading to PI 3-kinase activation is enhanced and insulin action is attenuated
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additional information
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multiple defects of PI 3-kinase activation, involving both the p85a and the p85b adaptor subunits, may contribute to cardiac insulin resistance
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additional information
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the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview
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additional information
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the lipid-lowering effect of leptin on livers from lean rats is mediated by the enzyme, diet-induced obesity abolishes the effect of leptin on the enzyme and the lipid level and causes leptin resistance
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PI3-kinase-dependent activation of diacylglycerol kinase and production of phosphatidic acid in caveolae/rafts in response to norepinephrine but not endothelin-1
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HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
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nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
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activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia
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PI3K is implicated in the phosphorylation of ERK and CaMKII in spinal neurons, and of NR2B subunits of the NMDA receptor, as well as in the increased synthesis of c-Fos and the trafficking of AMPA-R GluR1 subunit, all after formalin injection
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additional information
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nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
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additional information
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HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
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enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
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enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
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the enzyme is essential for protein sorting
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the enzyme is essential for protein sorting
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essential for normal cell growth and vacuole morphology
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PI3K inhibits recombinantly expressed rat excitatory amino acid transporter 4 in oocytes, which is inhibited by the specific PI3K inhibitor wortmannin
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generation of phosphatidyl 3,4,5-triphosphate by phosphatidylinositol 3-kinase is necessary for insulin-induced germinal vesicle breakdown in Xenopus oocytes
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lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase
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overexpression of mkrn2 completely abrogates constitutively active PI3K- and Akt-induced, but not dominant negative glycogen synthase kinase-3beta-induced, neural cell adhesion molecule expression, indicating that mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta. Important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development
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