2.7.1.138: ceramide kinase

This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.

Word Map on EC 2.7.1.138

2.7.1.138

ceramide-1-phosphate

sphingolipids

1-phosphate

sphingosine-1-phosphate

ceramidase

pleckstrin

cerkl

medicine

ceramide-induced

analysis

diagnostics

Reaction

Synonyms

acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.138 ceramide kinase

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Results	in table
10	Activating Compound
1476	AA Sequence
9	Application
1	CAS Registry Number
31	Cloned(Commentary)
31	Cofactor
133	Disease/ Diagnostics
6	Expression
42	General Information
2	General Stability
2	IC50 Value
41	Inhibitors
3	Ki Value [mM]
26	KM Value [mM]
58	Localization
40	Metals/Ions
4	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
72	Organism
1	Oxidation Stability
3	Pathway
1	PDB ID
13	pH Optimum
2	pH Range
4	Posttranslational Modification
53	Protein Variants
10	Purification (Commentary)
3	Reaction
24	Reaction Type
67	Reference
128	Source Tissue
11	Specific Activity [micromol/min/mg]
3	Storage Stability
173	Substrates and Products (Substrate)
3	Subunits
72	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]

Activating Compound

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Activating Compound on EC 2.7.1.138 - ceramide kinase

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A23187

Homo sapiens

calcium ionophore, 216% activation of ceramide kinase in A549 lung adenocarcinoma cells

640970

Ca2+

Homo sapiens

Q8TCT0

1 mM, stimulatory effect in the absence of Mg2+

Calcium

Calmodulin

binding site is located at residues 422-435, which form a amphipathic helical wheel, motif 1-8-14, calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor

662431

interleukin-1 beta

Homo sapiens

187% activation of ceramide kinase in A549 lung adenocarcinoma cells

640970

Mg2+

Homo sapiens

Q8TCT0

3 mM, highly dependent on Mg2+

662592

peroxisome proliferator-activated receptor beta

Mus musculus

upregulation of CERK through activation of peroxisome proliferator-activated receptor beta (PPARbeta) results in decreased intracellular ceramide levels and increased cell survival with less cell death

692307

Phorbol esters

Homo sapiens

e.g. PMA

661860

additional information

3 entries