2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
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pleckstrin
-
cerkl
- medicine
-
ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
ECTree
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Localization
Localization on EC 2.7.1.138 - ceramide kinase
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additional information
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ceramide is transported to the Golgi complex for phosphorylation by ceramide kinase
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bound to, probably via the pleckstrin homology domain of the enzyme
CERK also contains nuclear localization/export signals and traffics to the plasma membrane via microtubule-driven vesicles in response to hyperosmotic shock
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localization via the pleckstrin homology domain at the N-terminus
phosphorylation of ceramide by CERK at the cytoplasmic surface of the trans-Golgi network
microtubule-driven vesicles that traffic between the Golgi complex and the plasma membrane
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CERK can respond to stimuli by changing its localization, e.g. from Golgi to plasma membrane upon osmotic swelling, explaining perhaps the conflicting subcellular findings
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additional information
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subcellular localization may be dependent on the cell type
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additional information
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the enzyme is involved in vesicular trafficking and subcellular translocation involving its pleckstrin homology domain, the enzyme co-localizes with its substrate, overview
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additional information
truncation of the PH domain either from the N-terminus or C-terminus results in disruption of the PH domain fold and loss of wild type ceramide kinase localization
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