2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
-
pleckstrin
-
cerkl
- medicine
-
ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
ECTree
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Subunits
Subunits on EC 2.7.1.138 - ceramide kinase
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additional information
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subdomain structure of the enzyme, possessing a pleckstrin homology domain, a DAGK-like catalytic domain, and a Ca2+/calmodulin binding domain
additional information
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the enzyme possesses an N-terminal pleckstrin homology PH domain, residues 32-121, and a C-terminal region which contains a Ca2+/calmodulin binding domain, residues 378-455, that flanks the catalytic domain, residues 124-433, the enzyme also contains 5 sequences stretches C1-C5 typical for lipid kinases
additional information
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the N-terminus of the enzyme harbors a myristoylation site and the pleckstrin homology domain, the first is required for lipid anchor modification of the enzyme, the latter is required for membrane association or activity through high afinity binding of phosphatidyl inositol phosphate