2.7.1.145: deoxynucleoside kinase
This is an abbreviated version!
For detailed information about deoxynucleoside kinase, go to the full flat file.
Word Map on EC 2.7.1.145
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2.7.1.145
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thymidine
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drosophila
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deoxycytidine
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suicide
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deoxyguanosine
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herpes
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medicine
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deoxyadenosine
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e-5-2-bromovinyl-2'-deoxyuridine
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kinase-deficient
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dttp
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deoxythymidine
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dado
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1-beta-d-arabinofuranosylthymine
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synthesis
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agriculture
- 2.7.1.145
- thymidine
- drosophila
- deoxycytidine
-
suicide
- deoxyguanosine
-
herpes
- medicine
- deoxyadenosine
-
e-5-2-bromovinyl-2'-deoxyuridine
-
kinase-deficient
- dttp
- deoxythymidine
-
dado
- 1-beta-d-arabinofuranosylthymine
- synthesis
- agriculture
Reaction
Synonyms
AGCK, AgdNK, BmdNK, D. melanogaster deoxynucleoside kinase, deoxyribonucleoside kinase, deoxyribonucleoside kinase
ECTree
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Application on EC 2.7.1.145 - deoxynucleoside kinase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
agriculture
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multifunctional deoxynucleoside kinase of insect cells is a target for development of new highly selective insecticidial drugs
medicine
synthesis
additional information
DmdNK broad substrate specificity and fast turnover rate make it an interesting candidate for suicide gene therapy, as well as in numerous biotechnological applications
medicine
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enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
medicine
the enzyme activates a number of medically important nucleoside analogues
medicine
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the enzyme can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
medicine
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deoxynucleoside kinase gene is introduced into HeLa cells with cationic lipids, to allow its transient expression. Cytotoxicities of 1-beta-D-arabinofuranosylcytosine, 5-fluorodeoxyuridine, and 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine are increased by the deoxynucleoside kinase gene. The combination of the transient expression of the Drosophila deoxynucleoside kinase gene and these nucleoside analogs is a candidate for suicide gene therapy
medicine
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mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential
medicine
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transduced deoxyribonucleoside kinases can be used to kill recipient cells in combination with nucleoside prodrugs
medicine
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mitochondrial targeting of multisubstrate nucleoside kinase facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential
medicine
possible use of this enzyme as a suicide gene in vitro and in vivo
medicine
suicide gene dmdnk in several cancer cell lines, overview. In vivo testing in a xenograft model for breast cancer, both wild-type DmdNK and mutants of DmdNK are combined with gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine) as the NA prodrug and a positive effect of decreasing tumor volume and increased survival time
medicine
lentivirusx1emediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)-5-(2-bromovinyl)-2'-deoxyuridine or 1-beta-D-arabinofuranosylthymine therapy may be effective in treating keloid fibroblasts
medicine
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the enzyme is a potential candidate for reversing acquired gemcitabine resistance in triplex1enegative breast cancer cells, which may form the basis of strategies for the treatment of patients with drugx1eresistant triplex1enegative breast cancer
medicine
the recombinant enzyme is used to sensitize human cancer cell lines to gemcitabine
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
synthesis
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enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used forDNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
synthesis
the cross-linked DmdNK preparation is used for the preparative synthesis of arabinosyladenine monophosphate (ara-AMP) and fludarabine monophosphate (FaraAMP)
