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2.7.1.146: ADP-specific phosphofructokinase

This is an abbreviated version!
For detailed information about ADP-specific phosphofructokinase, go to the full flat file.

Word Map on EC 2.7.1.146

Reaction

ADP
+
D-fructose 6-phosphate
=
AMP
+
D-fructose 1,6-bisphosphate

Synonyms

ADP dependent phosphofructokinase, ADP-6-phosphofructokinase, ADP-dependent 6-phosphofructokinase, ADP-dependent glucokinase, ADP-dependent glucokinase/phosphofructokinase, ADP-dependent PFK, ADP-dependent phosphofructokinase, ADP-GK, ADP-Pfk, ancGK/PFK, AncMsPFK/GK, bifunctional ADP-dependent phosphofructokinase/glucokinase, MevePFK/GK, MJ1604, MjPFK/GK, MmazPFK/GK, MmPFK/GK, More, PFK, PFK-ADP, pfkC, PhPFK, TK0376, TLPFK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.146 ADP-specific phosphofructokinase

Engineering

Engineering on EC 2.7.1.146 - ADP-specific phosphofructokinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D433A
K158A
N160A
Q224A
R185A
R191A
R191E
S183A
the mutant shows strongly increased kcat compared to the wild type enzyme
S183E
S189A
S263A
D17A
-
the mutant shows severely decreased kcat compared to the wild type enzyme
-
K158A
-
the mutant shows slightly decreased kcat compared to the wild type enzyme
-
N160A
-
the mutant shows strongly increased kcat compared to the wild type enzyme
-
R191A
-
the mutant shows decreased kcat compared to the wild type enzyme
-
S183A
-
the mutant shows strongly increased kcat compared to the wild type enzyme
-
E72A
-
site-directed mutagenesis, the mutant shows reduced glucokinase and phosphofructokinase activities compared to wild-type enzyme