2.7.1.147: ADP-specific glucose/glucosamine kinase
This is an abbreviated version!
For detailed information about ADP-specific glucose/glucosamine kinase, go to the full flat file.
Word Map on EC 2.7.1.147
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2.7.1.147
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hyperthermophilic
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thermococcus
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embden-meyerhof
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litoralis
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phosphofructokinases
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jannaschii
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furiosus
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glucokinases
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ribokinase
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methanococcales
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thermococcales
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6-phosphofructokinase
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hexokinases
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atp-pfks
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methanosarcinales
- 2.7.1.147
-
hyperthermophilic
- thermococcus
-
embden-meyerhof
- litoralis
-
phosphofructokinases
- jannaschii
- furiosus
- glucokinases
- ribokinase
- methanococcales
- thermococcales
- 6-phosphofructokinase
- hexokinases
- atp-pfks
- methanosarcinales
Reaction
Synonyms
ADP-dependent glucokinase, ADP-dependent hexokinase, ADP-dependent kinase, ADP-GK, ADP-HK, ADP-Pfk, ADP-specific glucokinase, ADP:D-glucose 6-phosphotransferase, ADPGK, ancGK/PFK, AncMsPFK/GK, bifunctional ADP-dependent phosphofructokinase/glucokinase, GlcN kinase, glucosamine kinase, MevePFK/GK, MjPFK/GK, MmazPFK/GK, MmPFK/GK, More, NagC4, pfGK, pfkC, PhPFK, TK1110, tlGK
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Natural Substrates Products
Natural Substrates Products on EC 2.7.1.147 - ADP-specific glucose/glucosamine kinase
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REACTION DIAGRAM
AMP + D-glucosamine 6-phosphate
the enzyme functions as the glucosamine kinase responsible for the chitin degradation
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ADP + D-glucosamine
AMP + D-glucosamine 6-phosphate
the enzyme functions as the glucosamine kinase responsible for the chitin degradation
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?
AMP + D-glucose 6-phosphate
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first step of the Embden-Meyerhoff pathway
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r
ADP + D-glucose
AMP + D-glucose 6-phosphate
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the enzyme is involved in the modified Embden-Meyerhof pathway
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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first step of the Embden-Meyerhoff pathway
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r
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
the enzyme phosphorylates both D-glucose and D-fructose 6-phosphate. Binding of both substrates to the same active site. At a sugar concentration of 10 mM the acctivity with D-fructose 6-phosphate is about 75% compared to the activity with D-glucose. No activity in presence of ATP. kcat/KM for the phosphorylation of D-fructose 6-phosphate is 440fold higher than the kcat/Km for the phosphorylation of glucose. Analysis of the kcat/Km ratios shows that the glucose dephosphorylation is 2fold more effective than the phosphorylation
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r
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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?
ADP + D-glucose
AMP + D-glucose 6-phosphate
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ADP + D-glucose
AMP + D-glucose 6-phosphate
step of the Embden-Meyerhoff pathway
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D-glucose 6-phosphate + AMP
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ADP can be replaced by GDP and CDP to a limited extent
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D-glucose + ADP
D-glucose 6-phosphate + AMP
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CDP shows comparable activity
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ir
D-glucose + ADP
D-glucose 6-phosphate + AMP
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CDP shows comparable activity
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ir