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2.7.1.147: ADP-specific glucose/glucosamine kinase

This is an abbreviated version!
For detailed information about ADP-specific glucose/glucosamine kinase, go to the full flat file.

Word Map on EC 2.7.1.147

Reaction

ADP
+
D-glucosamine
=
AMP
+
D-glucosamine 6-phosphate

Synonyms

ADP-dependent glucokinase, ADP-dependent hexokinase, ADP-dependent kinase, ADP-GK, ADP-HK, ADP-Pfk, ADP-specific glucokinase, ADP:D-glucose 6-phosphotransferase, ADPGK, ancGK/PFK, AncMsPFK/GK, bifunctional ADP-dependent phosphofructokinase/glucokinase, GlcN kinase, glucosamine kinase, MevePFK/GK, MjPFK/GK, MmazPFK/GK, MmPFK/GK, More, NagC4, pfGK, pfkC, PhPFK, TK1110, tlGK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.147 ADP-specific glucose/glucosamine kinase

Substrates Products

Substrates Products on EC 2.7.1.147 - ADP-specific glucose/glucosamine kinase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + D-fructose
AMP + D-fructose 6-phosphate
show the reaction diagram
ADP + D-fructose 6-phosphate
AMP + D-fructose 1,6-bisphosphate
show the reaction diagram
the enzyme phosphorylates both D-glucose and D-fructose 6-phosphate. Binding of both substrates to the same active site. At a sugar concentration of 10 mM the activity with D-fructose 6-phosphate is about 75% compared to the activity with D-glucose. No activity in presence of ATP. kcat/KM for the phosphorylation of D-fructose 6-phosphate is 440fold higher than the kcat/Km for the phosphorylation of glucose
-
-
ir
ADP + D-glucosamine
AMP + D-glucosamine 6-phosphate
show the reaction diagram
ADP + D-glucose
AMP + D-glucose 6-phosphate
show the reaction diagram
ADP + D-mannose
AMP + D-mannose 6-phosphate
show the reaction diagram
ADP + N-acetyl-D-glucosamine
AMP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
the enzyme exhibits a low level of activity against N-acetyl-D-glucosamine
-
-
?
AMP + D-glucose 6-phosphate
ADP + D-glucose
show the reaction diagram
-
-
-
r
CDP + D-glucose
CMP + D-glucose 6-phosphate
show the reaction diagram
12% of the activity with ADP
-
-
?
D-1,5-anhydroglucitol + ADP
?
show the reaction diagram
D-glucose + ADP
D-glucose 6-phosphate + AMP
show the reaction diagram
GDP + D-glucose
GMP + D-glucose 6-phosphate
show the reaction diagram
TDP + D-glucose
TMP + D-glucose 6-phosphate
show the reaction diagram
about 10% compared to the activity with ADP
-
-
r
UDP + D-glucose
UMP + D-glucose 6-phosphate
show the reaction diagram
additional information
?
-