2.7.1.151: inositol-polyphosphate multikinase
This is an abbreviated version!
For detailed information about inositol-polyphosphate multikinase, go to the full flat file.
Word Map on EC 2.7.1.151
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2.7.1.151
-
phosphatidylinositol
-
phospholipase
-
phosphoinositide
-
4,5-bisphosphate
-
4-phosphate
-
5-phosphatase
-
1,3,4,5-tetrakisphosphate
-
bacteriorhodopsin
-
insp3
-
pip2
-
ptdins4,5p2
-
4-kinase
-
hexakisphosphate
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pikfyve
-
ptdins4p
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pentakisphosphate
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1,3,4-trisphosphate
-
3hinositol
-
phosphatidylinositol-4-phosphate
-
photocycle
-
diphosphoinositol
-
inositide
-
3,4,5-trisphosphate
-
5/6-kinase
-
polyphosphoinositide
-
medicine
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light-driven
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arf6
-
agriculture
- 2.7.1.151
- phosphatidylinositol
- phospholipase
- phosphoinositide
- 4,5-bisphosphate
- 4-phosphate
-
5-phosphatase
- 1,3,4,5-tetrakisphosphate
-
bacteriorhodopsin
- insp3
- pip2
-
ptdins4,5p2
-
4-kinase
- hexakisphosphate
- pikfyve
-
ptdins4p
- pentakisphosphate
- 1,3,4-trisphosphate
-
3hinositol
- phosphatidylinositol-4-phosphate
-
photocycle
-
diphosphoinositol
-
inositide
- 3,4,5-trisphosphate
-
5/6-kinase
-
polyphosphoinositide
- medicine
-
light-driven
- arf6
- agriculture
Reaction
Synonyms
1,3,4,6-tetrakisphosphate 5-kinase, 5-kinase, Arg82, ArgRIII, ARGSIII, AtIpk2a, AtIpk2b, AtIpk2beta, HsIPMK, Impk, inositol 1,4,5-trisphosphate 3-kinase, inositol phosphate multikinase, inositol phosphate multikinase 2, inositol polyphosphate 6-/3-kinase, inositol polyphosphate kinase, inositol polyphosphate multikinase, Ins(1,4,5)P3 3-kinase, InsP4 5-kinase, IP3 3-kinase, IP3/IP4 6-/3-kinase, IP3K, IPK, Ipk2, Ipk2/Impk/IP3K, Ipk2a, Ipk2beta/IP3K, IPKII, IPMK, ITPK1, Kcs1, Kcs1p, More, phosphoinositol kinase, PI3K, StIPMK
ECTree
2.7.1.151 inositol-polyphosphate multikinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.151 - inositol-polyphosphate multikinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate
2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
r
2 ATP + 1D-myo-inositol 4,5-bisphosphate
2 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate
ADP + diphosphoinositol pentakisphosphate
-
isozyme Kcs1
-
-
?
ATP + 1D-myo-inositol 1,2,3,4,6-pentakisphosphate
ADP + inositol hexakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ADP + diphosphoinositol tetrakisphosphate
-
isozyme Kcs1
-
-
?
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
r
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ATP + inositol 1,4,5,6-tetrakisphosphate
ADP + inositol (1,3,4,5,6)-pentakisphosphate
-
stable over-expression of the human protein in HEK-293 cells abrogates the in vivo elevation of inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein. The enzyme may play a role in regulation of the level of inositol 1,4,5,6-tetrakisphosphate in human cells
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol (3,4,5)-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
in rats
-
-
?
inositol (1,4,5,6)-tetrakisphosphate + ATP
inositol (1,3,4,5,6)-pentakisphosphate + ADP
-
inositol polyphosphate multikinase is a key mediators in the production of inositol (1,3,4,5,6)-pentakisphosphate
-
-
?
myo-inositol triphosphate + ATP
myo-inositol tetrakisphosphate + ADP
-
it appears that the enzyme utilizes inositol triphosphate as the initial substrate for the synthesis of higher myo-inositol polyphosphates
-
?
2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
in rats and humans
-
-
?
2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
in rats and humans
-
-
?
3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
in rats and humans
-
-
?
3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
in rats and humans
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
ir
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
recombinant enzyme in yeast mutant cells
-
-
?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
ir
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
preferred substrate of isozyme Ipk2
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
ir
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme initiates a inositol polyphosphate pathway, isozyme Kcs1 is also involved, inositol metabolism, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
-
-
-
ir
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
-
-
-
ir
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
-
-
-
ir
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
preferred substrate of isozyme Ipk2
-
-
?
ATP + 1D-myo-inositol 4,5-bisphosphate
ADP + 1D-myo-inositol 3,4,5-trisphosphate
-
-
-
?
ATP + 1D-myo-inositol 4,5-bisphosphate
ADP + 1D-myo-inositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 4,5-bisphosphate
ADP + 1D-myo-inositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 4,5-bisphosphate
ADP + 1D-myo-inositol 3,4,5-trisphosphate
-
-
-
-
?
additional information
?
-
-
the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview
-
-
?
additional information
?
-
AtIpk2b Is an auxin-inducible gene and is important for the auxin signaling pathway
-
-
?
additional information
?
-
IP3K is involved in axillary shoot branching via Auxin signaling
-
-
?
additional information
?
-
-
Genome-wide RNA interference screen in cultured Drosophila melanogaster haemocyte-like cells identifies as a regulator of the Janus tyrosine kinase/signal transducer and activator of transcription.
-
-
?
additional information
?
-
-
the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview
-
-
?
additional information
?
-
-
the enzyme might be involved in regulation of cell growth
-
-
?
additional information
?
-
-
the enzyme regulates inositol 1,4,5,6-tetrakisphosphate
-
-
?
additional information
?
-
-
inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate
-
-
?
additional information
?
-
-
Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of inositol pentakisphosphate and inositol hexakisphosphate
-
-
?
additional information
?
-
-
The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells.
-
-
?
additional information
?
-
-
inositol polyphosphate multikinase is a multifunctional enzyme with PI3-kinase, IP3-kinase and catalytically independent activities. IPMK is a PI3-kinase which phosphorylates PIP2 into PIP3, serving as a physiologic activator of Akt/PKB. It also possesses IP3-kinase activity, converting IP3 into IP4 (1,3,4,5) or IP4 (1,4,5,6). Whether the phosphorylation of IP3 at the 3-position or the 6-position is physiologically regulated
-
-
?
additional information
?
-
inositol polyphosphate multikinase is an enzyme that displays soluble inositol phosphate kinase activity, lipid kinase activity, and various noncatalytic interactions
-
-
?
additional information
?
-
-
inositol polyphosphate multikinase is an enzyme that displays soluble inositol phosphate kinase activity, lipid kinase activity, and various noncatalytic interactions
-
-
?
additional information
?
-
IPMK is a broad-specificity enzyme that converts inositol 1,4,5-trisphosphate into inositol 1,4,5,6-tetrakisphosphate (IP4) and subsequently inositol 1,3,4,5,6-pentakisphosphate
-
-
?
additional information
?
-
-
the enzyme plays an essential role in mouse embryogenesis and second messenger production
-
-
?
additional information
?
-
the absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate
-
-
?
additional information
?
-
-
the absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate
-
-
?
additional information
?
-
-
Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of InsP5 and InsP6
-
-
?
additional information
?
-
-
The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells.
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of telomere length and cell death, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview
-
-
?
additional information
?
-
-
the enzyme is involved inregulation of arginine-sensitive ArgR-Mcm1 transcriptional complex, overview
-
-
?
additional information
?
-
-
the enzyme is required for resistance to salt stress, cell wall integrity, and vascuolar morphogenesis
-
-
?
additional information
?
-
-
the enzyme is involved inregulation of arginine-sensitive ArgR-Mcm1 transcriptional complex, overview
-
-
?
